What Is Sh-Pentapeptide-35?
Sh-Pentapeptide-35 is a lab-made fragment of the human protein Sirtuin 1. The peptide is built from five amino acids – arginine, glutamine, histidine and lysine – arranged in the same order found in our skin. Because it is produced synthetically, there is no animal or plant extraction involved, which helps keep quality and purity consistent from batch to batch.
The idea of copying parts of Sirtuin 1 for skin care grew out of research into how this protein supports cell health and longevity. Scientists found that a small section of the protein could be recreated as a standalone peptide and still deliver benefits when applied to skin. Cosmetic formulators adopted Sh-Pentapeptide-35 in the late 2010s as interest in gentle, bio-identical ingredients increased.
Manufacturing starts with solid-phase peptide synthesis, where each amino acid is added one at a time to create the exact sequence. After assembly, the peptide is purified, dried and blended into a water-soluble powder ready for use in creams or serums.
You will commonly see Sh-Pentapeptide-35 in anti-aging serums, firming creams, sheet masks, eye treatments and lightweight daily moisturizers aimed at improving skin texture and resilience.
Sh-Pentapeptide-35’s Cosmetic Benefits/Uses
This peptide brings one key benefit to skin care formulas.
Skin conditioning: Sh-Pentapeptide-35 helps the skin surface feel smoother and look more refined. By supporting the skin’s own proteins, it can soften the appearance of fine lines, enhance suppleness and promote a healthier-looking tone over time.
Who Can Use Sh-Pentapeptide-35
Thanks to its light, water-soluble nature, Sh-Pentapeptide-35 suits dry, normal, combination and oily skin. Sensitive skin generally tolerates it well because the peptide is bio-identical and free of common irritants. People with extremely reactive or allergy-prone skin should still monitor how their skin feels, as with any new ingredient.
The peptide is made entirely in the lab and contains no animal-derived materials, so it is suitable for vegans and vegetarians.
No data suggests that topical Sh-Pentapeptide-35 poses a specific risk to those who are pregnant or breastfeeding. This is not medical advice and anyone expecting or nursing should review all skincare choices with a qualified healthcare provider.
The ingredient does not increase photosensitivity, so it can be used day or night without raising sun-related concerns. Standard daily sunscreen use is still recommended for overall skin health.
Potential Side Effects/Adverse Reactions
Responses to Sh-Pentapeptide-35 can differ from person to person. The points below outline possible but uncommon reactions when the peptide is applied to skin in a properly formulated product.
- Mild redness or warmth shortly after application
- Temporary itching or tingling
- Rare allergic contact dermatitis leading to persistent irritation
- Stinging when applied to compromised or broken skin
If any of these reactions occur discontinue use and consult a healthcare professional for guidance.
Comedogenic Rating
Rating: 0 / 5
Sh-Pentapeptide-35 is a tiny water-soluble molecule that contains no oils, waxes or heavy emollients. Because it dissolves completely in the water phase of a formula and does not leave a film on the skin surface, it has virtually no potential to clog pores. As a result it is considered non-comedogenic.
Suitable for acne-prone or breakout-prone skin.
The only time pore issues could arise is if the peptide is blended into a product that uses other comedogenic ingredients. In that case the overall formula, not the peptide itself, would be the culprit.
Summary
Sh-Pentapeptide-35 is a lab-crafted five-amino-acid fragment of the Sirtuin 1 protein used for skin conditioning. When applied topically it supports the skin’s own proteins which can smooth fine lines, improve suppleness and promote a more refined skin tone.
While not yet a household name it is gaining steady interest among formulators looking for gentle bio-identical actives that pair well with a wide range of textures and skin types.
Current data and real-world use show it to be very safe with only rare reports of mild irritation. As with any new skincare ingredient it is wise to perform a simple patch test before full-face use to make sure your skin agrees with the formula.