What Is Sh-Polypeptide-102?
Sh-Polypeptide-102 is a lab-made version of a small protein known as Heat Shock Protein 10 (Hsp 10). In our bodies these proteins help other proteins keep their shape when cells are under stress like heat or pollution. Scientists noticed that this protective role could be useful on skin, so they developed a synthetic, skin-safe form for cosmetics.
To create Sh-Polypeptide-102, biotech methods are used. A harmless strain of bacteria or yeast is given the genetic code for Hsp 10, grown in a tank, then prompted to produce the protein. After fermentation the mixture is filtered and purified so only the desired polypeptide remains. The result is a stable, water-soluble ingredient that can be blended into creams and serums without losing strength.
Skin care brands began adding heat shock proteins to formulas in the early 2000s when research showed they could help skin cope with daily stress. Today Sh-Polypeptide-102 appears in moisturizers, anti-aging creams, protective day lotions, sheet masks and recovery serums aimed at shielding skin from environmental damage.
Sh-Polypeptide-102’s Cosmetic Benefits/Uses
In products applied to skin this ingredient offers one main benefit.
Sh-Polypeptide-102 acts as a skin-protecting agent. By mimicking the body’s own stress-response proteins it helps maintain the structure of skin cells when they face heat, UV light or pollution. This supportive action can reduce the look of damage, keep the skin barrier steady and leave skin feeling calmer and more resilient.
Who Can Use Sh-Polypeptide-102
Because it is water based and free of oils or clogged-pore fillers, Sh-Polypeptide-102 suits most skin types including oily, dry, sensitive and combination. People with easily irritated skin may even welcome its calming, barrier-supporting effect. There are currently no reports of it being unsuitable for any specific skin type.
The ingredient is produced through biotechnology using microbes, not animal tissue, so it is typically considered vegan and vegetarian friendly. Always check the full product label to be sure the finished formula has no animal-derived additives.
Current data shows no reason pregnant or breastfeeding women must avoid Sh-Polypeptide-102. Still this is not medical advice and anyone who is expecting or nursing should run all skincare choices past a qualified doctor to stay on the safe side.
Sh-Polypeptide-102 does not make skin more sensitive to sunlight, so it will not increase the risk of sunburn. Standard daytime sun care is still recommended for overall skin health.
Potential Side Effects/Adverse Reactions
Side effects from topical Sh-Polypeptide-102 can vary from person to person. The points below list potential issues yet these outcomes are unlikely for most users when the ingredient is used correctly in a well-formulated product.
- Mild redness or warmth right after application
- Temporary stinging on very broken or freshly exfoliated skin
- Itching or dryness in individuals sensitive to any preservative or carrier used alongside the peptide
- Rare allergic contact dermatitis in those with a specific protein allergy
If you experience any persistent or worsening reaction stop using the product and seek advice from a healthcare professional.
Comedogenic Rating
Rating: 0/5. Sh-Polypeptide-102 is a water-soluble micro-protein with no fatty or waxy residues so it does not sit in pores or form a film that blocks sebum flow. Because it is supplied at very low concentrations and is commonly paired with lightweight bases it poses virtually no risk of clogging pores on its own. That makes it well suited to skin that breaks out easily. As always the overall formula matters; heavy oils or thick silicones in the same product can raise the final comedogenic potential.
Summary
Sh-Polypeptide-102 is a lab-crafted version of Heat Shock Protein 10 that shields skin cells from daily stress, helping maintain a stable barrier and a calmer appearance. By acting like our native stress-response proteins it keeps other skin proteins in proper shape when exposed to heat, UV or pollution, which can translate to fewer signs of irritation and a stronger feel.
The peptide has a modest but growing fan base, mainly in premium serums and recovery creams aimed at stressed or mature skin. It is still less common than well-known actives like niacinamide yet formulators value its gentle, supportive profile.
Current research and user reports point to a very low risk of irritation, no pore-clogging tendency and no photosensitivity. That said every skin is different so it is wise to patch test any new product containing Sh-Polypeptide-102 before full use just to be safe.