What Is Sh-Polypeptide-107?
Sh-Polypeptide-107 is a lab crafted version of a human peptide that plays a role in the natural repair work inside our cells. Scientists take a synthesized copy of the gene that codes for a protein called Mitochondrial Peptide Methionine Sulfoxide Reductase, insert it into E. coli and let the bacteria ferment. During this controlled process the bacteria become tiny factories that churn out the peptide, which is then purified for cosmetic use. The finished ingredient is a single-chain protein of up to 235 amino acids, sometimes linked by disulfide bonds or carrying small sugar groups. Interest in this peptide grew as skin care brands looked for gentle yet effective ways to support the skin’s own renewal processes, and advances in fermentation tech made large-scale production both reliable and affordable. Today you can spot Sh-Polypeptide-107 in lightweight serums, anti-aging creams, sheet masks, eye treatments and overnight moisturizers where it is added to keep skin feeling smooth and resilient.
Sh-Polypeptide-107’s Cosmetic Benefits/Uses
In topical products Sh-Polypeptide-107 serves one core purpose: skin conditioning. It helps improve the look and feel of skin by supporting hydration, keeping the surface supple and reducing the rough texture that can come with dryness or environmental stress. Regular use can leave skin softer, more elastic and generally healthier in appearance which is why formulators add it to products designed for daily care as well as targeted repair treatments.
Who Can Use Sh-Polypeptide-107
Because it is a lightweight water-soluble peptide Sh-Polypeptide-107 is considered friendly for all major skin types including dry, normal, combination, oily and even sensitive skin. It does not contain pore-clogging oils or harsh exfoliating acids so it rarely worsens acne or triggers irritation in reactive complexions.
The peptide is produced by fermentation in bacteria with no animal-derived material in the finished ingredient so it is suitable for both vegetarians and vegans.
Current research shows no specific risks for women who are pregnant or breastfeeding when the peptide is used topically in cosmetics. This information is not medical advice and anyone who is expecting or nursing should review any new skincare product with a qualified health professional before adding it to a routine.
Sh-Polypeptide-107 is not known to make skin more sensitive to sunlight so it does not increase the risk of sunburn. Of course regular sunscreen use is still recommended as part of daily skincare.
Potential Side Effects/Adverse Reactions
Side effects from topical Sh-Polypeptide-107 vary from person to person. The following list covers potential reactions though most users will not experience them when the ingredient is formulated and used correctly
- Localized redness or mild stinging
- Temporary itching or dryness in very sensitive skin
- Allergic contact dermatitis in individuals with a specific protein allergy
- Interaction with other active ingredients leading to cumulative irritation when layered with strong acids or retinoids
If any uncomfortable reaction occurs discontinue use and seek advice from a healthcare professional
Comedogenic Rating
Rating: 0
Sh-Polypeptide-107 is a large water-soluble peptide with no oily or waxy components so it does not settle into pores or form a film that traps sebum. This makes it effectively non-comedogenic for most users. In formulas it is typically used at low percentages and paired with light humectants which further limits any pore-clogging potential.
Suitable for acne-prone and breakout-prone skin.
As with any ingredient, the total product formula matters. If Sh-Polypeptide-107 appears in a rich balm or heavy cream the overall comedogenicity will be influenced more by those base ingredients than by the peptide itself.
Summary
Sh-Polypeptide-107 conditions the skin by supporting hydration, improving surface smoothness and helping maintain elasticity. It does this by mimicking the skin’s natural repair peptides, encouraging a healthier moisture balance and reinforcing the skin barrier so it feels softer and more resilient.
The peptide is gaining attention in targeted serums and eye creams but is still a niche active compared with mainstream ingredients like hyaluronic acid. As fermentation technology becomes more cost-effective it is likely to appear in a wider range of products.
Current data shows Sh-Polypeptide-107 to be very safe for topical use with low irritation and no known photosensitivity. As with any new skincare product it is wise to perform a quick patch test on a small area to confirm personal tolerance.