What Is Sh-Polypeptide-110?
Sh-Polypeptide-110 is a lab engineered form of basic fibroblast growth factor also known as FGF-5 or heparin-binding growth factor 5. In nature this protein helps guide cell growth and repair in skin and hair follicles. Scientists isolate the gene that codes for FGF-5, insert it into a safe microbial host such as yeast or E. coli, then ferment the culture under controlled conditions. The microbes produce the peptide, which is harvested, purified and stabilized for use in cosmetics. Because it is bio-identical to the body’s own growth factor it can be used in formulas aimed at improving the look and feel of skin and hair.
The cosmetic industry first explored growth factors in the early 2000s while searching for gentle yet effective alternatives to retinoids and acids. Sh-Polypeptide-110 gained traction after in-vitro studies suggested it could support healthier looking follicles and smoother skin texture. Today you will most often see it in leave-on hair tonics, scalp serums, anti-shedding masks, anti-aging face serums, lightweight moisturizers and post-treatment soothing gels.
Sh-Polypeptide-110’s Cosmetic Benefits/Uses
This peptide offers two key functions that make it a versatile addition to beauty formulas
- Hair conditioning: Helps create an optimal environment for stronger fuller looking strands by supporting the scalp’s natural renewal cycle. Over time hair can appear thicker healthier and more resilient to breakage
- Skin conditioning: Encourages smoother softer skin by aiding surface cell turnover and maintaining moisture balance which can reduce the look of fine lines and rough patches
Who Can Use Sh-Polypeptide-110
Sh-Polypeptide-110 is considered gentle enough for most skin types including dry oily combination and mature skin. It has a lightweight water based profile so it will not clog pores or leave a heavy residue which means even acne-prone users usually tolerate it well. Those with extremely reactive or broken skin barriers should introduce it cautiously because any bioactive peptide could prompt temporary tingling or warmth.
The ingredient is produced through microbial fermentation rather than animal extraction so it is typically suitable for vegans and vegetarians. Always check the full ingredient list and brand certifications to confirm no secondary animal derived stabilizers have been added.
There is no published evidence showing harm to pregnant or breastfeeding women when Sh-Polypeptide-110 is applied topically in cosmetic concentrations. Still safety data is limited and hormonal shifts can make skin unpredictable. This information is not medical advice and anyone who is pregnant or nursing should review all skincare products with a healthcare provider first.
Unlike exfoliating acids or retinoids this growth factor does not increase photosensitivity. Standard daytime sun protection is still recommended to protect the skin but there is no special photo caution linked specifically to Sh-Polypeptide-110.
Potential Side Effects/Adverse Reactions
Side effects and reactions to topical Sh-Polypeptide-110 differ from person to person. The points below outline potential issues yet most users who apply a properly formulated product will not experience them.
- Mild redness or warmth shortly after application
- Temporary itching or stinging in sensitive areas
- Localized rash or hives indicating an allergic response
- Contact dermatitis when combined with high concentrations of other active ingredients such as unbuffered acids or alcohol heavy formulas
- Eye irritation if the serum accidentally drips into the eyes
If any of these reactions occur stop using the product and consult a medical professional to determine the appropriate next steps.
Comedogenic Rating
Rating: 0 / 5
Sh-Polypeptide-110 is a water soluble protein fragment with no oils, waxes or fatty acids so it does not sit in pores or create the kind of film that can trap sebum. Its large molecular size also limits deep penetration into sebaceous ducts where blockages start. For these reasons it earns a solid 0 on the comedogenic scale.
Because of this low score the ingredient is generally suitable for people who are prone to acne or frequent breakouts.
Keep in mind overall pore clogging potential depends on the full formula. Heavy butters, silicones or fragrances paired with Sh-Polypeptide-110 could still trigger congestion even though the peptide itself is non comedogenic.
Summary
Sh-Polypeptide-110 is a lab made version of basic fibroblast growth factor that conditions both hair and skin. On the scalp it supports a balanced renewal cycle which can make strands look fuller and stronger. On the face it encourages smoother texture and better moisture retention by nudging surface cells to turn over at a healthy rate.
The peptide is gaining popularity in niche hair serums and anti aging skincare but it remains less common than mainstream actives like niacinamide or peptides such as copper tripeptide. Interest is rising as consumers look for gentle performance ingredients that avoid irritation.
Current data shows topical use is low risk for most people when used at cosmetic levels. Still everyone’s skin is unique so it is smart to patch test any new product containing Sh-Polypeptide-110 before committing to full application.