What Is Sh-Polypeptide-120?
Sh-Polypeptide-120 is a lab-engineered chain of amino acids that mirrors a segment of the human protein known as E2F-4, which plays a role in cell cycle regulation. Because it is a synthetic copy, it does not come from animal or plant tissue but is produced through biotechnology. Manufacturers insert the genetic blueprint for this peptide into safe strains of bacteria or yeast, let the microbes grow in stainless-steel tanks, then harvest and purify the peptide. This process ensures a high level of consistency and eliminates concerns about animal-derived contaminants.
The cosmetic world became interested in Sh-Polypeptide-120 when research showed that peptides modeled after human signaling proteins could help skin look smoother and better hydrated. Over the past decade formulators have explored these lab-made peptides as gentler, more targeted options compared with older actives like retinoids or strong acids.
You will usually find Sh-Polypeptide-120 in leave-on products that aim to improve skin texture and resilience. Common formats include lightweight serums, anti-aging moisturizers, sheet masks and eye creams where the goal is to support a healthy looking skin barrier and a plump finish.
Sh-Polypeptide-120’s Cosmetic Benefits/Uses
This peptide is prized for one main role in skincare products:
As a skin conditioning agent, Sh-Polypeptide-120 helps the skin surface feel softer and more supple. It supports moisture retention, which can reduce the appearance of fine lines caused by dehydration and leave the complexion looking fresher throughout the day.
Who Can Use Sh-Polypeptide-120
Because it is lightweight and non occlusive, Sh-Polypeptide-120 works well for most skin types including dry, oily, combination and sensitive. Those with very reactive skin may still prefer to introduce any new peptide product slowly so they can gauge tolerance.
The ingredient is produced through fermentation, not harvested from animals, which makes it suitable for both vegans and vegetarians.
Current research gives no indication that Sh-Polypeptide-120 poses unique risks during pregnancy or while breastfeeding. That said this is not medical advice, and anyone who is pregnant or nursing should review all skincare choices with a qualified physician to be cautious.
Sh-Polypeptide-120 does not increase photosensitivity, so it can be used morning or night without raising the risk of sunburn. Normal daily sunscreen habits should still be followed.
Potential Side Effects/Adverse Reactions
Reactions to topical Sh-Polypeptide-120 differ from person to person. The points below list potential side effects, but most users will not encounter them when the ingredient has been formulated and applied as intended.
- Mild redness or flushing shortly after application
- Itching or tightness in very sensitive skin
- Rare allergic contact dermatitis leading to persistent rash
- Increased irritation if layered with highly acidic or exfoliating products
If any of these symptoms occur and do not quickly resolve, discontinue use and seek advice from a healthcare professional.
Comedogenic Rating
Rating: 0 (non-comedogenic)
Sh-Polypeptide-120 is a small, water-soluble peptide that does not leave an oily film or block pores. It contains no fatty acids or waxes that typically trigger congestion, so it earns the lowest spot on the comedogenic scale.
That makes it suitable for skin prone to acne or frequent breakouts.
Keep in mind that the overall pore-clogging potential of a finished product depends on the full formula; heavy butters or silicones paired with this peptide could raise the comedogenic profile even if the peptide itself is innocuous.
Summary
Sh-Polypeptide-120 is a lab-crafted mimic of the human E2F-4 protein that conditions skin by helping it hold on to water, leaving the surface softer and plumper. Its water-binding action smooths fine dehydration lines and supports a healthy-looking barrier without greasiness.
The peptide is quietly gaining traction in mid to high-end serums and creams but is not yet as mainstream as collagen peptides or niacinamide. Brands that focus on biotech actives and minimalist formulas are the primary adopters right now.
Overall safety data are favorable; most users tolerate it well with minimal risk of irritation or pore blockage. Still, skin is individual, so it is wise to patch test any new product containing Sh-Polypeptide-120 before full-face use to ensure personal compatibility.