What Is Sh-Polypeptide-124?
Sh-Polypeptide-124 is a lab-made version of a human protein chain. Scientists start with a synthesized copy of the gene that codes for part of the T-cell receptor and insert it into a harmless strain of E. coli. The bacteria are grown in large tanks where they produce the peptide during fermentation. Afterward the peptide is separated, purified and carefully folded so its structure, including any disulfide bonds or light sugar attachments, matches the human form. The finished protein can contain up to 268 standard amino acids.
Biotechnology advances in the early 2000s made it possible to craft human-identical peptides at scale. Formulators soon realized that these gentle yet active molecules could boost the feel and appearance of skin without the irritation sometimes linked to stronger actives. Today Sh-Polypeptide-124 appears in a range of topical products such as firming serums, anti-aging creams, lightweight moisturizers, concentrated ampoules, eye treatments and sheet masks.
Sh-Polypeptide-124’s Cosmetic Benefits/Uses
This ingredient is prized for its ability to condition skin.
As a skin-conditioning agent Sh-Polypeptide-124 helps skin hold onto moisture, supports a smooth surface and promotes a comfortable feel. Regular use can leave the complexion looking supple and refreshed while helping other hydrating ingredients perform better.
Who Can Use Sh-Polypeptide-124
Sh-Polypeptide-124 is generally suitable for all skin types including dry, oily, combination and sensitive skin because its main role is to condition and support the skin barrier without leaving a heavy or greasy feel. Those with extremely reactive or allergy-prone skin should still check the full formula for other triggers but the peptide itself is considered gentle.
The peptide is produced through bacterial fermentation with no animal-derived components so it fits vegan and vegetarian lifestyles.
Current research shows no specific risks for pregnant or breastfeeding women when the ingredient is used topically and in the small amounts found in cosmetics. That said this is not medical advice. If you are expecting or nursing ask your healthcare provider before adding any new skincare product just to be safe.
Sh-Polypeptide-124 does not make skin more sensitive to sunlight and can be used morning or night without raising the risk of sunburn. It also pairs well with common actives such as niacinamide vitamin C and hyaluronic acid.
Potential Side Effects/Adverse Reactions
Reactions to topical Sh-Polypeptide-124 differ from person to person. The points below outline potential side effects yet they are uncommon when the ingredient is formulated and used correctly.
- Mild redness or warmth at the application site
- Transient itching or tingling
- Minor swelling in very sensitive individuals
- Rare allergic contact dermatitis
If you notice any of these effects stop using the product and seek guidance from a healthcare professional.
Comedogenic Rating
Rating: 0 (non comedogenic)
Sh-Polypeptide-124 is a large water soluble protein with no oily components so it cannot lodge inside pores or feed acne‐causing bacteria. It is used in tiny amounts and tends to stay on the skin surface, making pore blockage highly unlikely.
Those who break out easily can generally use products featuring this peptide without worrying about extra congestion.
If blemishes appear they are far more likely to come from heavier base ingredients or fragrances in the finished formula rather than the peptide itself.
Summary
Sh-Polypeptide-124 is a bioengineered peptide that conditions skin by attracting and holding moisture, smoothing rough spots and reinforcing the barrier so the surface stays comfortable and resilient. Its human identical structure lets it deliver these benefits with very little risk of irritation.
The peptide is still a niche addition seen mainly in premium serums, creams and masks, but its gentle nature and science-backed origin are helping it become more popular each year.
Current evidence shows the ingredient is non comedogenic, vegan friendly and rarely irritates, yet it is still smart to perform a quick patch test when trying any new product that contains it just to make sure your skin stays happy.