What Is Sh-Polypeptide-13?
Sh-Polypeptide-13 is a lab-made peptide that mirrors a fragment of the human protein called Noggin, often labeled as NOG in scientific texts. By copying a snippet of this naturally occurring protein, skincare chemists aim to tap into its soothing and protective traits without using animal or human tissue directly. The peptide is produced through recombinant technology: genes that code for the desired amino-acid sequence are inserted into harmless bacteria or yeast, those microbes then grow in large stainless-steel tanks and churn out the peptide, which is later purified, filtered and dried into a fine powder. First explored by Korean and Japanese formulators looking for gentle skin protectors in the early 2010s, Sh-Polypeptide-13 quickly found its way into premium moisturizers and sheet masks. Today you can spot it in barrier-repair creams, anti-aging serums, overnight masks and even soothing after-sun lotions where it helps keep the skin calm and resilient.
Sh-Polypeptide-13’s Cosmetic Benefits/Uses
In skincare formulas Sh-Polypeptide-13 serves one key purpose.
As a skin protecting agent it forms a light, breathable layer that helps shield the surface of the skin from everyday stressors like pollution and dry air. This soft film supports the skin barrier, reduces moisture loss and can make the complexion feel smoother and more comfortable, especially when paired with hydrating ingredients such as glycerin or hyaluronic acid.
Who Can Use Sh-Polypeptide-13
Because it is lightweight and non greasy Sh-Polypeptide-13 is considered suitable for all major skin types including dry, normal, combination and oily. It has no occlusive oils or heavy waxes so even breakout-prone faces tend to tolerate it well. Sensitive skin usually gets along with it too thanks to its calming role, though of course individual reactions can happen.
The peptide is made entirely through fermentation in controlled laboratory settings so no animal tissue or by-products are involved. That makes it a vegan and vegetarian-friendly choice.
Current data shows no specific risks for women who are pregnant or breastfeeding when the ingredient is used topically in cosmetic amounts. Still this is not medical advice and anyone expecting or nursing should have their doctor review any skincare product for extra peace of mind.
Sh-Polypeptide-13 does not increase photosensitivity and has no known impact on how skin handles sunlight. As always daily sunscreen is recommended for overall skin health.
Potential Side Effects/Adverse Reactions
Side effects from topical Sh-Polypeptide-13 vary from person to person. The points below list potential issues only they are unlikely to reflect the average experience when the ingredient is included in a well-formulated product.
- Mild redness or warmth some people may feel a transient flush that settles quickly
- Itching or stinging especially on very compromised or freshly exfoliated skin
- Localized rash or hives in the rare case of an allergy to the peptide or another formula component
- Breakouts generally uncommon but possible if the full product contains pore-clogging companions even though the peptide itself is non comedogenic
- Interaction with strong acids low pH treatments may degrade the peptide reducing effectiveness and potentially provoking irritation in sensitive users
If any persistent or severe reaction occurs stop using the product and consult a healthcare professional.
Comedogenic Rating
Rating: 0 / 5
Sh-Polypeptide-13 is a small, water-soluble peptide that does not contain heavy oils, waxes or long-chain fatty acids, so it sits on the skin without blocking pores. Its film-forming action is lightweight and easily rinsed away, leaving no residue that could trap sebum or dead cells. As a result it is generally suitable for acne-prone or breakout-prone skin.
Any pimples that appear while using a product with this peptide are more likely tied to other ingredients in the formula, a poor cleansing routine or unrelated hormonal shifts.
Summary
Sh-Polypeptide-13 is a lab-crafted copy of a fragment of the human Noggin protein that acts mainly as a skin protecting agent. It forms a thin breathable veil that helps defend the barrier, keeps moisture from escaping and calms stressed complexions. While not yet as mainstream as niacinamide or peptides like Matrixyl it is gaining quiet popularity in barrier creams, soothing serums and after-sun masks, especially among K-beauty brands.
Current research and real-world use suggest excellent safety with very low risk of irritation, allergy or pore clogging when used at typical cosmetic levels. Even so it is smart to patch test any new product to make sure your skin agrees with the whole formula.