What Is Sh-Polypeptide-15?
Sh-Polypeptide-15 is a lab engineered version of a naturally occurring human protein known as Tissue Inhibitor of Metalloproteinases-2. Scientists create it by inserting a synthesized human gene into a harmless strain of E. coli, then letting the bacteria ferment in controlled tanks. After fermentation the peptide is isolated, purified and carefully checked so the final material is a single-chain protein containing up to 220 amino acids, the same 20 that make up the proteins in our skin. Because the production is done in a closed lab setting, the ingredient is both consistent and free from animal-derived contaminants.
The idea of using human identical peptides in skincare took off in the early 2000s when formulators looked for ways to signal the skin to behave more youthfully without irritation. Sh-Polypeptide-15 entered cosmetic labs soon after, offering a targeted approach to support the skin’s natural balance of enzymes that break down collagen. Today you will most often spot it in anti-aging serums, firming creams, overnight masks and specialty eye treatments where maintaining skin smoothness is the main goal.
Sh-Polypeptide-15’s Cosmetic Benefits/Uses
In formulas Sh-Polypeptide-15 is valued for one key role
Skin conditioning: By helping regulate enzymes that can weaken the skin’s support network, this peptide promotes a smoother, more resilient surface. Formulas that include it aim to improve overall texture, reduce the look of fine lines and keep skin feeling supple over time.
Who Can Use Sh-Polypeptide-15
Thanks to its gentle nature Sh-Polypeptide-15 is considered suitable for every skin type, including dry, normal, combination, oily and sensitive. It does not add oil or occlusive waxes so acne-prone users generally tolerate it well. People with very reactive skin should still introduce any new peptide slowly because individual sensitivities are always possible, but there is no clear reason this ingredient would be off-limits for any particular skin group.
The peptide is produced through bacterial fermentation with no animal-derived material, which makes it appropriate for vegans and vegetarians.
Current research has not flagged Sh-Polypeptide-15 as a concern for pregnancy or breastfeeding. That said this information is meant for general knowledge only. Expectant or nursing users should run any skincare routine by a qualified healthcare provider to be on the safe side.
The ingredient does not cause photosensitivity, so it will not make skin more vulnerable to sunburn. Normal daytime sun protection is still recommended for overall skin health.
Potential Side Effects/Adverse Reactions
Responses to topical Sh-Polypeptide-15 can vary from person to person. The points below list potential effects, but most users will not notice any problems when the product is made and used correctly.
- Mild redness or warmth
- Temporary itching or stinging on sensitive skin
- Localized rash if an individual is allergic to the peptide or other formula components
- Eye irritation if product is accidentally rubbed into the eyes
If any of these reactions occur stop using the product and consult a healthcare professional for advice.
Comedogenic Rating
Rating: 0 / 5 (non-comedogenic)
Sh-Polypeptide-15 is a water-soluble protein with no oils, waxes or fatty acids that could clog pores. It stays on the skin surface or is absorbed without leaving a greasy film, so it does not trap debris inside follicles. This makes it suitable for people who are prone to acne or breakouts.
As with any ingredient the finished formula matters. If Sh-Polypeptide-15 is blended into a product rich in heavy butters or comedogenic silicones the overall product could still congest pores, but the peptide itself will not be the cause.
Summary
Sh-Polypeptide-15 is a lab-made copy of a human protein that helps keep the skin’s own collagen-breaking enzymes in check. In cosmetics it acts as a skin conditioning agent, working to maintain a smoother, firmer appearance and support overall resilience. Formulators appreciate that it delivers these benefits without irritation or heaviness.
While not yet as mainstream as classic peptides like palmitoyl pentapeptide-4, interest is rising thanks to the broader buzz around biomimetic actives. You will mainly find it in higher-end serums, eye creams and overnight treatments aimed at visible firmness.
Safety profiles from both lab testing and real-world use are reassuring, showing low risk of sensitization or pore blockage. Still, everyone’s skin is unique so it is wise to patch test any new product that features this peptide before committing to full-face use.