What Is Sh-Polypeptide-16?
Sh-Polypeptide-16 is a lab-engineered chain of amino acids that mimics two naturally occurring growth factors, PGF and PLGF, which play a role in keeping skin cells healthy. Because it is created through biotechnology rather than harvested from animals or plants, it offers a consistent purity and avoids ethical concerns linked to animal-derived ingredients. Scientists first explored synthetic growth factor peptides in the early 2000s as a way to deliver skin benefits without the instability of full-sized proteins. Over time formulators discovered that shorter, well-designed peptide sequences like Sh-Polypeptide-16 could provide similar protective effects while staying stable in creams and serums.
Production starts with fermenting harmless strains of bacteria or yeast that have been given the genetic blueprint for the desired peptide. Once the microorganisms churn out enough peptide, the mixture is filtered and purified, then blended with humectants or encapsulated to help it mix evenly into cosmetic bases.
You will most often spot Sh-Polypeptide-16 in leave-on products such as anti-aging serums, daytime moisturizers, overnight masks, sheet masks and specialty treatments aimed at reinforcing the skin barrier. It may also appear in soothing after-sun lotions, post-procedure balms and eye creams where an extra layer of skin protection is welcome.
Sh-Polypeptide-16’s Cosmetic Benefits/Uses
In topical formulas Sh-Polypeptide-16 is valued mainly for one key job.
Skin protecting: By signaling skin cells to fortify their outer layers, the peptide helps strengthen the barrier that keeps moisture in and daily irritants out. A more resilient barrier means skin feels softer, looks calmer and is less likely to react to pollution, weather shifts or harsh ingredients in other products.
Who Can Use Sh-Polypeptide-16
Because it is lightweight and non-occlusive Sh-Polypeptide-16 suits nearly every skin type, including oily, combination, dry and sensitive complexions that are easily irritated by heavy textures or fragrances. It does not clog pores so acne-prone users can generally apply it without worry. At the moment there are no known reasons for people with specific dermatological conditions to avoid it but anyone with a history of peptide allergies should proceed cautiously.
The peptide is synthesized by fermenting microorganisms rather than being harvested from animal tissue which makes it acceptable for vegans and vegetarians.
No hormonal activity has been reported so products with Sh-Polypeptide-16 are usually viewed as low risk for women who are pregnant or breastfeeding. That said this is not medical advice and expecting or nursing mothers should still run any new skincare product past a qualified health professional.
Sh-Polypeptide-16 does not increase photosensitivity. Standard daytime sunscreen habits are still recommended to protect the skin from UV damage but no extra precautions are needed solely because of this ingredient.
The peptide is compatible with most common actives such as niacinamide retinoids and vitamin C so formulators often layer it into multi-benefit products without stability issues.
Potential Side Effects/Adverse Reactions
Individual responses to topical Sh-Polypeptide-16 can differ. The points below outline potential side effects yet most users will not experience them when the ingredient is properly formulated and used as directed.
- Temporary redness or flushing
- Mild itching or tingling immediately after application
- Dry patches if the formula lacks sufficient emollients for very dehydrated skin
- Contact dermatitis in rare individuals with a peptide sensitivity
- Interaction-related irritation when layered with highly acidic treatments if the overall product pH shifts too low
If any of these reactions occur stop using the product and seek guidance from a healthcare professional or dermatologist.
Comedogenic Rating
Rating: 0/5
Sh-Polypeptide-16 is a small, water-soluble peptide with no oily carriers or waxy residues, so it does not linger in pores or form a film that could trap sebum. Formulas typically include it at low concentrations, further reducing any clogging risk. Because of this profile it is considered non-comedogenic and is generally suitable for skin that is prone to acne or breakouts.
Unless the finished product pairs the peptide with heavy oils or butters its presence should not influence pore blockage. Always check the whole ingredient list if breakouts are a concern.
Summary
Sh-Polypeptide-16 is a lab-designed growth factor–mimicking peptide that mainly protects the skin by signaling cells to reinforce their outer barrier. A stronger barrier locks in moisture, keeps irritants out and helps skin appear calmer and smoother.
While not as famous as peptides like Matrixyl or copper tripeptide it is slowly gaining traction in barrier-focused serums and moisturizers thanks to its stability and vegan production method.
Current research and user reports point to a high safety margin with low chances of irritation or pore clogging. Still, every formula is unique so it is wise to patch test any new product containing Sh-Polypeptide-16 before full-face use.