What Is Sh-Polypeptide-2 Sr-Egyptian Scorpion Oligopeptide-1?
Sh-Polypeptide-2 Sr-Egyptian Scorpion Oligopeptide-1 is a lab designed fusion peptide that brings together two different peptide sequences, one inspired by human growth factors and the other modeled after a bioactive fragment found in Egyptian scorpion venom. Scientists join the two genes then place the new gene inside a harmless strain of E. coli. As the bacteria grow in a fermentation tank they churn out the 141 amino acid chain, which is later purified, folded into the right shape and gently dried into a stable powder. The result is a water-soluble ingredient ready to blend into cosmetic bases.
The beauty industry’s interest in this peptide began when researchers noted that some scorpion venom fragments could calm surface irritation while boost skin resilience. By linking such a fragment to a well known skin signaling peptide they created a hybrid with a broader protecting profile, making it attractive for modern skincare lines. Today the ingredient is most often found in lightweight serums, sheet masks, barrier repair creams, anti aging moisturizers, soothing after-sun gels and targeted eye treatments where formulators want a gentle yet technologically advanced shield for the skin.
Sh-Polypeptide-2 Sr-Egyptian Scorpion Oligopeptide-1’s Cosmetic Benefits/Uses
This fusion peptide is primarily valued for its skin protecting role in topical products. It helps strengthen the skin’s own barrier, reduces the look of stress caused by pollution or sun exposure and supports overall comfort. By reinforcing the outer layer it can also limit moisture loss and improve the feel of sensitive or freshly exfoliated skin.
Who Can Use Sh-Polypeptide-2 Sr-Egyptian Scorpion Oligopeptide-1
This peptide is considered friendly for all major skin types including normal, dry, oily and combination because it focuses on barrier support rather than heavy moisturization or oil control. Sensitive skin often tolerates it well since the molecule is designed to calm surface stress, but anyone with a known allergy to peptides or ferment-derived ingredients should proceed cautiously.
The ingredient is produced in a microbial fermentation tank with no animal-derived inputs, so it fits vegan and vegetarian preferences.
No data suggest the peptide penetrates deeply or acts like a hormone, so it is not flagged as risky for pregnant or breastfeeding women. Still this is not medical advice. Expecting or nursing mothers should show the full product label to their healthcare provider before use just to be safe.
The peptide itself is not known to make skin more sensitive to sunlight and it pairs well with daytime formulas that already include SPF. It also plays nicely with most common actives such as niacinamide or hyaluronic acid, though layering it alongside very strong acids or retinoids may not add extra benefit.
Potential Side Effects/Adverse Reactions
Side effects from topical use of Sh-Polypeptide-2 Sr-Egyptian Scorpion Oligopeptide-1 can vary from person to person. The points below outline potential reactions only and most users will not experience them when the ingredient is formulated and used correctly.
- Mild redness or warmth at the application site
- Temporary itching or tingling as the product absorbs
- Rare allergic contact dermatitis in individuals sensitive to peptides or fermentation by-products
- Stinging if applied over broken or freshly shaved skin
- Interaction irritation when layered immediately after high-strength chemical exfoliants
If any of these reactions occur discontinue use and consult a healthcare professional for further guidance.
Comedogenic Rating
Rating: 0/5 (non-comedogenic)
This peptide is a large water-soluble molecule with no fatty chains, waxes or heavy silicones that could clog pores. It simply sits on the skin surface delivering its protective signals, so it is not expected to block follicles or trap sebum.
Suitable for acne-prone or breakout-prone skin.
Because its performance depends on the overall formula, tiny amounts of oils or butters added by a brand could change the final product’s pore-clogging potential, but the peptide itself remains a zero.
Summary
Sh-Polypeptide-2 Sr-Egyptian Scorpion Oligopeptide-1 is a lab-crafted fusion peptide that strengthens the skin barrier, helps limit moisture loss and soothes visible irritation. It works by mimicking beneficial skin signals while borrowing calming traits from a scorpion-derived fragment, giving cells a gentle nudge to reinforce their own defenses.
Right now it sits in the niche corner of high-tech skincare. A handful of indie and professional brands showcase it in serums and masks, but it has not yet reached mainstream buzz.
Current data show a low risk profile with minimal reported reactions when used as directed. As with any new skincare ingredient users should patch test a fresh product on a small area first to rule out individual sensitivity.