What Is Sh-Polypeptide-22?
Sh-Polypeptide-22 is a lab designed version of a natural human protein called Transforming Growth Factor Beta 1. Scientists create a synthetic gene that matches the human gene for this protein, insert it into a common bacterium (E. coli) and let the bacteria ferment in controlled tanks. During fermentation the bacteria turn that genetic code into a single chain peptide made of up to 390 amino acids, sometimes featuring tiny bridges called disulfide bonds and sugar attachments known as glycosylation. After purification the result is a highly consistent, bio-engineered peptide that can be added to skincare formulas.
The move to include peptides like Sh-Polypeptide-22 in cosmetics began in the early 2000s when brands were searching for gentler yet effective anti-aging options. Thanks to advances in recombinant DNA technology manufacturers could finally produce human-identical proteins without relying on animal sources, making the ingredient both ethical and scalable.
Today Sh-Polypeptide-22 shows up in a range of topical products that aim to revitalize the look and feel of skin. You will most often spot it in serums, concentrated ampoules, sheet masks, eye creams, overnight treatments and premium moisturizers marketed for firmness, elasticity support and overall skin renewal.
Sh-Polypeptide-22’s Cosmetic Benefits/Uses
In skincare formulas Sh-Polypeptide-22 is valued for one key job.
Skin conditioning: This peptide helps improve the appearance and texture of skin by supporting a smoother, softer feel. Formulators use it to give products a premium touch that can leave the complexion looking more refined and resilient over time.
Who Can Use Sh-Polypeptide-22
Because Sh-Polypeptide-22 is a gentle, skin conditioning peptide it is considered suitable for dry, normal, combination and oily skin types. Sensitive skin generally tolerates it well, though anyone with a known allergy to proteins or peptides should proceed with caution. People dealing with open wounds or active infections should wait until the skin has healed before applying products that contain this ingredient.
The peptide is produced through bacterial fermentation without any animal derived materials, making it appropriate for vegans and vegetarians.
Current research has not flagged topical Sh-Polypeptide-22 as a concern for pregnant or breastfeeding women. This is not medical advice and anyone who is expecting or nursing should have their healthcare provider review any skincare product they plan to use just to be safe.
The ingredient does not increase photosensitivity, so it will not make skin more prone to sunburn. Standard daytime sun protection is still recommended for overall skin health. Sh-Polypeptide-22 also plays nicely with most other cosmetic actives and is typically fragrance free, which further supports its broad compatibility.
Potential Side Effects/Adverse Reactions
Responses to topical Sh-Polypeptide-22 vary from person to person. The effects listed below are potential outcomes and are not expected for the average user when the ingredient is properly formulated and applied.
- Mild redness or warmth
- Transient stinging or tingling shortly after application
- Localized irritation on compromised or very dry skin
- Contact dermatitis in individuals with a peptide allergy
- Breakouts if the finished formula contains comedogenic companion ingredients
If any of these reactions occur discontinue use and consult a qualified healthcare professional.
Comedogenic Rating
Rating: 0/5 Sh-Polypeptide-22 is a large, water-soluble protein with no oily or waxy backbone, so it lacks the ability to clog pores. Its molecule is too big to settle inside follicles and has no occlusive characteristics that would trap sebum or debris. This makes it a non-comedogenic choice in virtually any formula.
Suitable for acne-prone or breakout-prone skin.
If a product containing Sh-Polypeptide-22 does cause pimples the culprit is likely another ingredient such as heavy oils, esters or thick silicones, not the peptide itself.
Summary
Sh-Polypeptide-22 is a lab-grown copy of Transforming Growth Factor Beta 1 used in skincare mainly for skin conditioning. By mimicking a native human protein it helps the surface feel smoother, appear firmer and look more refreshed without aggressive action or irritation.
It is not the most common peptide on shelves yet it shows up in higher-end serums, masks and eye treatments aimed at anti-aging benefits. Its ethical biotech sourcing and compatibility with most actives are nudging its popularity upward as brands seek gentle performance ingredients.
Topical use is considered very safe with low risk of sensitization or pore clogging. Still, skin can be unpredictable so perform a quick patch test when trying any new product that lists Sh-Polypeptide-22 to ensure personal comfort and tolerance.