Sh-Polypeptide-36: What Is It, Cosmetic Uses, Benefits & Side Effects

Curious about this ingredient? In this article we're explaining exactly what it is and why it's used within cosmetic formulations.
Updated on: June 30, 2025
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We verify all information on this page using publicly available nomenclature standards from The Personal Care Products Council (PCPC), the European Commission's CosIng database and documentation provided directly by ingredient manufacturers. Our analysis is based on technical data from these sources to ensure accuracy and reliability.

What Is Sh-Polypeptide-36?

Sh-Polypeptide-36 is a lab made version of the human protein interleukin-17 alpha, produced through a fermentation process that uses the friendly bacterium E. coli. Scientists start by creating a synthetic gene that matches the human one, insert it into the bacteria, then let the microbes do the work of building the peptide chain of up to 155 amino acids. After fermentation the peptide is carefully purified, checked for quality and readied for cosmetic use. Interest in bio-engineered peptides took off in the early 2000s as brands searched for gentle yet high-performance ingredients. Because Sh-Polypeptide-36 is identical to a naturally occurring human protein it caught formulators’ attention as a soothing skin conditioner that could be made consistently in large batches. Today you will most often spot it in lightweight serums, sheet masks, anti-aging moisturizers, post-treatment calming gels and specialty eye creams, where it helps create a smooth comfortable feel on the skin.

Sh-Polypeptide-36’s Cosmetic Benefits/Uses

In topical products Sh-Polypeptide-36 serves one primary role, yet that single role delivers several visible perks for the skin.

Skin conditioning: The peptide supports a balanced skin environment which helps keep the surface soft and supple. By reinforcing comfort and reducing signs of dryness it can make a formula feel more soothing on application and leave skin looking healthier and well cared for.

Who Can Use Sh-Polypeptide-36

Thanks to its gentle skin-conditioning nature, Sh-Polypeptide-36 is considered suitable for dry, oily, combination and sensitive skin alike. It has no known ingredients that would clog pores or trigger excess oil so acne-prone users usually tolerate it well. Because the peptide is produced in a laboratory and is free of animal-derived materials the finished raw material is appropriate for both vegans and vegetarians. Pregnant or breastfeeding individuals can generally use products containing Sh-Polypeptide-36, as the peptide remains on the surface of the skin, yet this is not medical advice and anyone expecting or nursing should always confirm product choices with a healthcare professional. The ingredient does not increase photosensitivity, meaning it will not make skin more prone to sunburn, though daily sunscreen is still recommended for overall skin health. There are no known conflicts with common actives such as vitamin C, retinoids or exfoliating acids, making it easy to slot into most routines.

Potential Side Effects/Adverse Reactions

Reactions to topical Sh-Polypeptide-36 vary from person to person. The points below outline potential side effects but most users will not experience them when the ingredient is correctly formulated and used as directed.

  • Mild redness or warmth a short-lived flush can occur if skin is highly reactive
  • Temporary itching or tingling usually subsides once the product dries
  • Localized irritation rare stinging or burning sensations may appear, especially on compromised skin barriers
  • Allergic contact dermatitis very uncommon but possible if an individual is sensitive to the peptide or other formula components

If any of these effects develop discontinue use immediately and consult a medical professional for guidance.

Comedogenic Rating

Rating: 0 (non-comedogenic)

Sh-Polypeptide-36 is a water-soluble peptide with no oily or waxy components so it does not sit inside pores or form a film that traps dead skin cells. It is usually added at very low levels and is rinsed or absorbed without leaving residue. For these reasons it earns a solid 0 on the comedogenic scale which means it will not clog pores.

Because of this low rating the ingredient is considered friendly for people who are prone to acne or frequent breakouts.

One extra point worth noting is that the final feel of any product still depends on the full formula. Heavy butters or silicones used alongside the peptide can change how the finished product behaves on acne-prone skin, so always look at the complete ingredient list.

Summary

Sh-Polypeptide-36 is a lab made copy of the body’s own interleukin-17 alpha that works in skincare as a skin-conditioning agent. By supporting a balanced surface environment it helps skin feel soothed soft and comfortable. It does this without adding occlusive weight or interfering with other actives.

The peptide is still a niche addition rather than a mainstream blockbuster but it is slowly gaining fans among brands looking for gentle high tech ingredients that play well with sensitive skin.

Safety data and real-world use show it to be low risk with only rare irritation reports. Even so it is smart to do a quick patch test when trying any new product to make sure your skin agrees with the full formula.

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