What Is Sh-Polypeptide-43?
Sh-Polypeptide-43 is a lab made peptide that copies the exact protein sequence of the human signaling molecule interleukin-6. Scientists create its gene in the lab, insert it into harmless E. coli bacteria, then let the bacteria grow in large tanks. The bacteria read the gene and build the peptide, which is later purified so only the clean protein remains. The finished ingredient is a single chain of up to 212 amino acids and can include natural features like tiny sulfur bridges or sugar side groups that help keep its shape.
The use of bioengineered peptides in skin care took off in the early 2000s when brands looked for targeted, skin friendly actives that could be made without animal sources. Sh-Polypeptide-43 joined this trend thanks to its ability to keep skin feeling balanced and comfortable. You can now spot it in lightweight serums, anti aging creams, restorative masks, post-procedure gels and intensive moisturizers where it supports a healthy skin environment.
Sh-Polypeptide-43’s Cosmetic Benefits/Uses
Formulators rely on Sh-Polypeptide-43 mainly for one key role
Skin conditioning: The peptide helps the skin hold moisture, feel soothed and stay in a balanced state. This can make formulas feel more comforting and can improve the look of dryness or temporary irritation, leaving the complexion soft and supple.
Who Can Use Sh-Polypeptide-43
This peptide is gentle enough for nearly every skin type, including dry, oily, combination, mature and even sensitive complexions, because it conditions without adding heavy oils or fragrances. Those with extremely reactive or allergy-prone skin should still proceed cautiously, as with any new ingredient.
Sh-Polypeptide-43 is produced entirely through bacterial fermentation, so it contains no animal-derived material. That makes it compatible with vegan and vegetarian lifestyles provided the finished formula also stays free of animal by-products.
Current research suggests the peptide stays on the skin’s surface and is unlikely to enter the bloodstream, so it is generally considered low risk for pregnant or breastfeeding women. This is not medical advice, and anyone who is pregnant or nursing should review any skincare product with a qualified health professional first, just to be safe.
The ingredient does not cause photosensitivity, so it can be used morning or night. Standard daytime sun protection is still recommended to guard against everyday UV damage.
Potential Side Effects/Adverse Reactions
Responses to topical Sh-Polypeptide-43 differ from person to person. The effects listed below are possible but uncommon, and most users will not experience them when the ingredient is formulated and used correctly.
- Mild redness or flushing
- Transient stinging or burning on application
- Itchiness or tingling
- Localized rash or hives in those with peptide allergies
- Contact dermatitis if combined with other irritants in the same formula
If you notice any of these reactions stop using the product and seek guidance from a healthcare professional
Comedogenic Rating
Rating: 0 / 5
Sh-Polypeptide-43 is a water soluble, oil free peptide that sits lightly on the skin and does not clog pores. It lacks waxes, heavy oils or fatty acids that usually trigger breakouts, so it earns the lowest possible comedogenic score.
Because of this non pore clogging nature, the ingredient is considered suitable for people who are prone to acne or frequent blemishes.
Keep in mind that the overall formula also matters. A product packed with rich butters could still feel heavy despite the peptide itself being non comedogenic.
Summary
Sh-Polypeptide-43 is a lab crafted copy of human interleukin-6 used mainly to condition skin. It supports a calm, hydrated surface by helping the skin hold moisture and feel soothed, which can reduce the look of dryness and short-term irritation.
While peptides as a group have become buzzworthy in recent years, this specific one is still a boutique choice found mostly in higher end serums and recovery creams rather than everyday drugstore lines.
Overall safety data are positive. The peptide is vegan friendly, non photosensitizing and shows a very low risk of irritation or clogged pores. As with any new skincare step it is smart to perform a small patch test first to make sure your skin agrees with the final formula.