What Is Sh-Polypeptide-47?
Sh-Polypeptide-47 is a lab-made version of a human collagen fragment. Scientists start with a synthesized copy of the gene that codes for collagen alpha 1, insert it into a strain of E. coli, then let the bacteria ferment in controlled tanks where they act as mini factories producing the peptide. After fermentation the peptide is purified, checked for quality and readied for use in skincare. Chemically it is a single-chain protein that can include up to 1,464 amino acids along with possible disulfide bonds or light sugar groups, all of which help the peptide stay stable and effective on skin.
The idea of borrowing peptides from human biology for beauty dates back to the early 2000s when brands began focusing on biomimetic ingredients that signal skin to act younger. As formulation technology improved researchers moved from animal-derived collagen to precise synthetic sequences like Sh-Polypeptide-47, giving products a vegan-friendly profile and better consistency batch after batch.
Today you will spot Sh-Polypeptide-47 in leave-on moisturizers, anti-aging serums, sheet masks, concentrated ampoules and post-treatment soothing creams where its skin-conditioning talent supports smoother, more resilient skin.
Sh-Polypeptide-47’s Cosmetic Benefits/Uses
In topical products Sh-Polypeptide-47 performs one key role: skin conditioning. By reinforcing the skin’s surface proteins and attracting water it helps maintain softness, improve bounce and create a healthier-looking complexion, making formulas feel richer and more nurturing on application.
Who Can Use Sh-Polypeptide-47
Because this peptide focuses on hydration and surface conditioning rather than heavy oils or exfoliating acids, it suits nearly every skin type. Dry and mature skin benefit from the extra moisture-binding ability while oily and combination skin appreciate that the ingredient is lightweight and non-greasy. Sensitive skin usually tolerates it well since the molecule is biomimetic and free of known sensitising fragrances or dyes. There are no inherent traits that make Sh-Polypeptide-47 unsuitable for any specific skin type, though individuals with a confirmed allergy to peptides or fermentation-derived proteins should use caution.
The peptide is produced in a laboratory through bacterial fermentation, with no animal tissues involved, which makes it appropriate for vegans and vegetarians.
Current data shows no direct risks for those who are pregnant or breastfeeding. That said this information is not medical advice; anyone expecting or nursing should have their healthcare provider review every skincare product they plan to use just to be safe.
Sh-Polypeptide-47 does not increase photosensitivity and can be applied morning or night without raising the skin’s vulnerability to sunlight. It also pairs well with most common actives such as niacinamide, hyaluronic acid and mild antioxidants.
Potential Side Effects/Adverse Reactions
Reactions to topical Sh-Polypeptide-47 differ from person to person. The points below outline potential side effects yet these outcomes are uncommon when the ingredient is correctly formulated and used as directed.
- Transient redness or warmth immediately after application
- Mild itching or tingling in very sensitive skin
- Rare allergic contact dermatitis presenting as rash or swelling
- Breakout or congestion if the finished formula also contains pore-clogging emollients
If any of these reactions develop stop using the product and seek advice from a qualified healthcare professional.
Comedogenic Rating
Rating: 0 / 5
Sh-Polypeptide-47 is a large water-soluble peptide with no oily residues or waxy carriers, so it does not clog pores on its own. Its molecular size means it sits mainly on the skin surface, providing conditioning benefits without blocking follicular openings. This makes it suitable for people who are prone to acne or breakouts.
Any pimples that appear while using a product containing this peptide are usually linked to the other ingredients in the formula such as heavy butters or silicones, not the peptide itself.
Summary
Sh-Polypeptide-47 is a lab-designed fragment of human collagen that conditions skin by supporting surface proteins and attracting moisture, leading to improved softness and resilience. Though not yet a household name, it is gaining steady traction in moisturizers, serums and post-procedure treatments where gentle hydration is valued.
Current research and consumer feedback show it to be very safe with a low risk of irritation or pore blockage. As with any new skincare product, a short patch test is wise to confirm personal compatibility.