What Is Sh-Polypeptide-54?
Sh-Polypeptide-54 is a lab made version of a human protein known as Insulin-Like Growth Factor Binding Protein 2. Scientists create the gene that codes for this protein, insert it into a Trichoplusia ni host system, then let the host ferment and produce the peptide. After fermentation the peptide is filtered and purified so only the desired single-chain protein with up to 325 amino acids remains. The result is a stable ingredient that can be added to skin care formulas.
The idea of using growth-factor-inspired peptides in cosmetics gained traction in the early 2000s when brands started looking for gentler options to support skin renewal. Advances in recombinant technology made it possible to produce precise human-identical peptides without animal sourcing, opening the door for Sh-Polypeptide-54 to appear in beauty products.
You will typically find this ingredient in anti-aging serums, firming creams, sheet masks, eye gels and post-procedure soothing products where extra skin support is desired.
Sh-Polypeptide-54’s Cosmetic Benefits/Uses
This peptide is valued for its ability to improve how skin looks and feels.
Skin conditioning: Sh-Polypeptide-54 helps skin hold on to moisture, leaving it softer and more supple. Consistent use can reduce the appearance of fine lines and rough patches, promote a smoother surface and give a healthier overall look.
Who Can Use Sh-Polypeptide-54
Because Sh-Polypeptide-54 is primarily a lightweight skin conditioning agent, it is generally suitable for all skin types including dry, normal, combination and oily. Its water-based nature means it will not add extra oil to the skin, making it friendly for acne-prone users. Sensitive skin typically tolerates the peptide well, although those with a history of reacting to ferment-derived ingredients should proceed carefully.
The peptide is produced through a bio-fermentation process that does not involve animals, so products using it are usually considered vegan and vegetarian friendly. To be sure, always verify that the full formula and manufacturing process of a specific product meet personal ethical standards.
No data suggest that topical Sh-Polypeptide-54 poses a special risk for pregnant or breastfeeding individuals. Still, this is not medical advice and anyone who is pregnant or nursing should confirm any new skincare product with a qualified healthcare provider to stay on the safe side.
The ingredient is not known to increase photosensitivity, so it will not make skin more prone to sunburn. Standard daily sunscreen use is still recommended for overall skin health.
Potential Side Effects/Adverse Reactions
Responses to topical Sh-Polypeptide-54 vary from person to person. The following points cover potential but uncommon side effects when the peptide is used in a properly formulated product
- Transient redness or warmth immediately after application
- Mild itching or tingling as the product absorbs
- Localized irritation for those sensitive to fermentation by-products
- Rare allergic contact dermatitis presenting as rash or swelling
If any of these effects occur stop use and consult a healthcare professional for guidance.
Comedogenic Rating
Rating: 0/5
Sh-Polypeptide-54 is a water-soluble peptide with no oils, waxes or heavy silicones, so it does not block pores. It sits lightly on the skin and is quickly absorbed, giving it a true non-comedogenic profile.
This makes the ingredient suitable for people who are prone to acne or breakouts.
Because it is normally used at low concentrations in serums and gels, the overall formula is also unlikely to feel greasy or occlusive, further lowering any pore-clogging risk.
Summary
Sh-Polypeptide-54 is a lab made version of a human growth-factor binding protein that conditions skin by supporting moisture balance and promoting a smoother surface. Its lightweight nature allows it to slip into the upper layers of the skin, where it helps keep water inside and softens rough spots.
While not yet a household name, the peptide is gaining quiet popularity among high-end and post-procedure skincare lines looking for gentle performance boosters.
Current data shows it is safe for most skin types with only rare irritation reported. As with any new skincare ingredient, patch test first to be sure your skin agrees with it.