What Is Sh-Polypeptide-56 Rh-Polypeptide-65?
Sh-Polypeptide-56 Rh-Polypeptide-65 is a lab-made fusion peptide designed to support skin and hair care. Scientists start by writing a custom gene that joins the genetic codes for sh-Polypeptide-56 and rh-Polypeptide-65. This gene is placed inside a friendly strain of E. coli. As the bacteria grow in a controlled fermenter they read the gene and build a long single-chain protein made of 1 104 amino acids, all drawn from the 20 common building blocks found in our own bodies. After fermentation the peptide is separated, purified, filtered and dried to a fine powder ready for cosmetic use.
The idea of adding bio-engineered peptides to beauty formulas took off in the early 2000s when brands looked for gentler alternatives to animal-derived proteins. Because this peptide can be made in stainless-steel tanks rather than harvested from natural sources, supply is steady and the risk of contamination is low. Its balanced mix of amino acids lets it sit comfortably on skin or hair where it can condition and protect.
Today you will spot Sh-Polypeptide-56 Rh-Polypeptide-65 in leave-on hair masks, smoothing conditioners, moisturizing creams, anti-aging serums, barrier-repair lotions and overnight sheet masks. Formulators like it because it dissolves easily in water-based systems, partners well with common preservatives and stays stable across the pH range typical of skin and hair products.
Sh-Polypeptide-56 Rh-Polypeptide-65’s Cosmetic Benefits/Uses
This multifunctional peptide lends several helpful properties to modern beauty care.
- Hair conditioning: Forms a lightweight film on the hair shaft that helps seal cuticles, reduce frizz and boost softness so strands feel smoother and look shinier after rinsing or throughout the day in leave-on products
- Skin conditioning: Binds water to the outer layer of skin, improving hydration, plumpness and overall feel which can soften the look of fine lines and dry patches
- Skin protecting: Creates a breathable shield that limits moisture loss and helps defend against everyday irritants like pollution and dry air, supporting a healthier skin barrier over time
Who Can Use Sh-Polypeptide-56 Rh-Polypeptide-65
This peptide is generally suitable for all skin and hair types, including dry, oily, combination and sensitive skin. Because it works mainly by adding lightweight hydration and forming a breathable protective film it rarely clogs pores or leaves a greasy finish. People with very protein-sensitive hair or known allergies to fermented ingredients should proceed with extra caution, as these conditions may lead to buildup or mild irritation.
Sh-Polypeptide-56 Rh-Polypeptide-65 is made entirely through microbial fermentation with no animal-derived inputs so it fits vegan and vegetarian lifestyles.
The current research on topical peptides shows no specific risks for pregnant or breastfeeding women when used in cosmetic concentrations. Still this is not medical advice and anyone who is pregnant or nursing should discuss new products with their healthcare provider first to be safe.
The ingredient does not make skin more sensitive to the sun and it can be used alongside daytime SPF without special precautions. It also plays well with most common actives such as niacinamide, hyaluronic acid and gentle exfoliating acids.
Potential Side Effects/Adverse Reactions
Reactions to Sh-Polypeptide-56 Rh-Polypeptide-65 differ from person to person. The points below list potential, not guaranteed, side effects. When the peptide is properly formulated most users will not notice any problems.
- Mild redness or stinging: usually temporary and resolves once the product is rinsed away or usage is reduced
- Itchiness or flushing: can arise in very sensitive skin when the formula is highly concentrated
- Allergic contact dermatitis: rare but possible in individuals with a protein allergy or sensitivity to fermentation byproducts
- Scalp buildup: heavy leave-on hair applications may weigh down fine hair or create residue if not washed out regularly
- Interaction with strong chemical exfoliants: very low pH formulas can denature the peptide and lessen its benefits but typically do not harm skin
If you notice any persistent discomfort stop using the product and consult a healthcare professional
Comedogenic Rating
Rating: 0 / 5
Sh-Polypeptide-56 Rh-Polypeptide-65 is a large, water-soluble peptide that stays on the skin surface and rinses away easily. It does not contain fatty acids, waxes or oils that typically block pores which is why it earns the lowest possible comedogenic score. This makes it a fine choice for people prone to acne or frequent breakouts. Formulas that pair the peptide with heavy butters or occlusive silicones could change the overall pore-clogging potential, so always consider the full ingredient list.
Summary
Sh-Polypeptide-56 Rh-Polypeptide-65 works as a hair conditioner, skin conditioner and skin protectant. It forms a light film that smooths hair cuticles, binds moisture to the outer skin layers and creates a breathable barrier that limits water loss and shields against daily irritants. Because it is produced by fermentation and not extracted from animals supply is steady and purity is high, yet the ingredient remains relatively niche compared to headline peptides like Matrixyl or copper tripeptide.
Current data shows the peptide is low risk for irritation or pore clogging at cosmetic levels. As with any new product though it is wise to perform a quick patch test before full use just to make sure your skin plays nicely.