What Is Sh-Polypeptide-57?
Sh-Polypeptide-57 is a lab-crafted chain of amino acids designed to copy a segment of the protein enzyme prolyl 4-hydroxylase, which helps build and stabilize collagen in skin. Chemists start by arranging amino acids in a set order, creating what is sometimes called a beta-peptide or P4HB fragment. The finished peptide is purified, blended into a water-based solution, then added to cosmetic formulas.
The ingredient first appeared in advanced skincare lines in the early 2000s, when researchers looked for gentler ways to keep skin proteins from breaking down. Because the peptide is small, it can sit on the skin surface and form a lightweight shield against daily wear. You will most often spot Sh-Polypeptide-57 in anti-aging serums, firming creams, sheet masks, overnight treatments and post-procedure soothing gels.
Sh-Polypeptide-57’s Cosmetic Benefits/Uses
Its key role is skin protecting. By coating the skin it helps defend against environmental stressors like pollution and dry air, which can weaken the outer layer. This protective action supports a smoother barrier, helping skin stay hydrated and reducing the look of early fine lines. When used regularly, products with Sh-Polypeptide-57 can leave the complexion feeling stronger and more resilient.
Who Can Use Sh-Polypeptide-57
Thanks to its lightweight water-based format, Sh-Polypeptide-57 suits virtually all skin types, including oily, dry, combination and sensitive. It does not clog pores or leave a greasy film, so acne-prone users usually tolerate it well. Those with a known allergy to synthetic peptides or to other ingredients in the finished product should avoid it, but such cases are rare.
The peptide is produced entirely in the lab without animal derivatives, making it appropriate for vegans and vegetarians.
No studies have flagged issues for people who are pregnant or breastfeeding, yet research on this group is limited. This is not medical advice; anyone expecting or nursing should show the product to a healthcare provider before adding it to a routine.
Sh-Polypeptide-57 does not make skin more sensitive to sunlight and can be applied morning or night without altering normal sunscreen habits.
Potential Side Effects/Adverse Reactions
Responses to topical Sh-Polypeptide-57 differ from person to person. The points below describe potential side effects that could occur, although most users experience none when the ingredient is formulated and used correctly.
- Mild redness or warming sensation shortly after application
- Temporary itching or tingling on very sensitive skin
- Rare allergic contact dermatitis presenting as swelling or rash
- Stinging if applied to broken or freshly exfoliated skin
If any of these reactions develop, stop using the product and consult a qualified medical professional for guidance.
Comedogenic Rating
Rating: 0 (non-comedogenic)
Sh-Polypeptide-57 is a water-based, lightweight peptide that sits on the surface of skin without leaving an oily film. It has no fatty acids or heavy waxes that can block pores, so it earns the lowest possible spot on the comedogenic scale.
That makes the ingredient suitable for people who are prone to acne or frequent breakouts.
Because it is typically used at very low concentrations and rinses off easily with regular cleansing, the chance of any buildup over time is minimal.
Summary
Sh-Polypeptide-57 is a lab-made peptide that shields skin from daily stress, supports a stronger moisture barrier and helps soften the look of early lines. It works by forming a thin, breathable layer on the surface that keeps irritants out and water in.
While not yet as famous as staples like hyaluronic acid or vitamin C, the peptide is gaining traction in niche anti-aging and post-procedure products thanks to its gentle profile.
Current safety data show it is well tolerated by nearly all skin types, with only rare reports of irritation or allergy. As with any new skincare ingredient, it is wise to try a small patch first to confirm personal compatibility before applying it to the full face.