What Is Sh-Polypeptide-59?
Sh-Polypeptide-59 is a lab made polypeptide that copies a small part of platelet derived growth factor, often labeled PDGF-2 or PDGFB. It is a chain of amino acids designed to send signals to skin cells so they look and act younger. The original protein was discovered in blood platelets in the 1970s and later studied for its role in wound repair. Scientists trimmed the protein to a shorter stable fragment and learned how to produce it in controlled fermentation tanks using bioengineered yeast or bacteria. After the peptide is harvested it is purified dried and added to water based solutions that can be mixed into skincare.
Beauty brands began testing this peptide in the early 2000s as part of the surge in peptide technology aimed at boosting the skin’s own renewal process. Today you can spot Sh-Polypeptide-59 in sheet masks, serums, essences, eye creams, firming moisturizers and post-procedure soothing gels.
Sh-Polypeptide-59’s Cosmetic Benefits/Uses
In formulas Sh-Polypeptide-59 plays one main role.
Skin conditioning – it helps skin feel softer, look smoother and stay hydrated by encouraging fresh cell turnover and supporting the skin surface matrix which can improve the appearance of fine lines uneven tone and a dull complexion.
Who Can Use Sh-Polypeptide-59
Sh-Polypeptide-59 is considered gentle enough for all common skin types including dry oily combination and sensitive skin because it is non exfoliating and does not alter skin pH. Those with highly reactive or allergy-prone skin should still check the complete ingredient list since irritation is more likely to come from fragrances or preservatives than from the peptide itself.
The peptide is produced in fermentation tanks using yeast or bacteria with no animal derivatives so it is suitable for vegans and vegetarians provided the finished product also avoids animal sourced additives like beeswax or collagen.
Current research has not flagged any specific risks for pregnant or breastfeeding women when the peptide is applied topically at the low percentages used in cosmetics. That said safety data during pregnancy is limited and individual circumstances vary so this information is not medical advice and anyone who is pregnant or nursing should ask a healthcare professional before adding new skincare to a routine.
Sh-Polypeptide-59 does not increase photosensitivity and can be used morning or night. As with most actives pairing it with daily sunscreen helps protect the new skin it encourages. It also layers well with common ingredients such as hyaluronic acid niacinamide vitamin C and retinoids without known negative interactions.
Potential Side Effects/Adverse Reactions
Side effects or reactions to topical Sh-Polypeptide-59 can vary from person to person. The points below list potential issues yet they are uncommon when the ingredient is formulated and used correctly.
- Mild redness or warmth – a temporary flush can appear when increased cell activity boosts local circulation
- Itching or stinging – most often linked to other formula components but occasionally the peptide itself may trigger nerve endings in very sensitive skin
- Contact dermatitis – rare allergic response leading to patches of inflammation swelling or tiny blisters
- Breakouts in acne-prone skin – if the overall formula is rich or occlusive congestion may occur even though the peptide itself is non comedogenic
- Interaction with microneedling or lasers – applying the peptide on freshly treated skin can intensify tingling or redness because the barrier is temporarily compromised
If any of these effects persist or worsen stop using the product and seek advice from a qualified healthcare provider.
Comedogenic Rating
Rating: 0 / 5 Water-soluble peptides like Sh-Polypeptide-59 do not leave an occlusive film or supply extra oil that could clog pores so they are considered non-comedogenic. This makes the ingredient a green light for those prone to acne or breakouts. The only caveat is that it is usually delivered in a finished formula, and heavier creams or oils in that formula could still cause congestion even though the peptide itself will not.
Summary
Sh-Polypeptide-59 is a bioengineered fragment of platelet derived growth factor that works as a skin-conditioning agent. By signaling skin cells to renew themselves more efficiently it helps surface texture look smoother and feel softer while subtly supporting firmness and an even tone. Although results are gentler than stronger actives, the peptide has built a quiet but steady fan base among brands focused on science-driven anti-aging blends and post-procedure care.
Current data show it is safe for topical use at cosmetic levels with very low risk of irritation or allergy. Still, everyone’s skin is unique so patch testing any new product that contains this peptide is the smartest way to make sure it suits your skin before applying it all over.