What Is Sh-Polypeptide-60?
Sh-Polypeptide-60 is a lab-made version of a small human protein called superoxide dismutase 1. Scientists start with a copy of the gene that tells the body how to build this protein, insert it into a harmless strain of E. coli bacteria and let the bacteria ferment in large tanks. During fermentation the bacteria read the gene and produce the peptide, which is then purified so that only the desired chain of up to 154 amino acids remains. The finished ingredient may include natural links known as disulfide bonds and small sugar groups, both of which help the protein keep its shape and stay stable.
The cosmetic world became interested in this peptide when research showed that the natural form of superoxide dismutase helps protect skin from everyday environmental stress. By creating a reliable synthetic copy companies gained a steady, vegan friendly source that does not rely on animal tissue. Over the past decade it has been added to a growing range of products, often marketed for its soothing and revitalizing touch.
Today you will most often find Sh-Polypeptide-60 in lightweight serums, anti aging creams, sheet masks, after-sun gels and hydrating moisturizers. It can also appear in focused treatment drops aimed at dull or stressed skin, where brands pair it with antioxidants, vitamins or calming plant extracts.
Sh-Polypeptide-60’s Cosmetic Benefits/Uses
In formulas Sh-Polypeptide-60 is valued for one key role.
Skin conditioning: the peptide helps skin feel softer, smoother and well cared for. By supporting the surface barrier it can reduce the tight, dry sensation that follows exposure to wind, sun or indoor heating. This conditioning effect also makes other active ingredients more pleasant to use since the overall texture of the product remains silky rather than sticky or heavy.
Who Can Use Sh-Polypeptide-60
Thanks to its lightweight water-soluble nature Sh-Polypeptide-60 fits well with nearly every skin type. Dry or mature skin benefits from the extra conditioning layer while oily or combination skin appreciates that it does not add greasiness. Sensitive skin generally tolerates it because the peptide is non-fragrant and has a neutral pH, though anyone with a known protein allergy should proceed carefully.
The ingredient is produced entirely through bacterial fermentation with no animal-derived material, making it suitable for vegans and vegetarians who wish to avoid animal input throughout the supply chain.
Current data shows no known risks for pregnant or breastfeeding women when the peptide is used topically, yet this information is educational only and not medical advice. Expectant or nursing mothers should always have a quick word with their healthcare provider before adding new skincare products, just to be safe.
Sh-Polypeptide-60 does not trigger photosensitivity, so it will not make skin more prone to sunburn. Standard daytime sunscreen habits are still recommended for overall skin health.
Potential Side Effects/Adverse Reactions
Responses to topical Sh-Polypeptide-60 vary from person to person. The points below outline potential side effects, but most users will not experience them when the ingredient is formulated and used correctly.
- Temporary redness or warmth mainly in very reactive skin
- Mild itching or stinging immediately after application, usually subsides quickly
- Localized rash or hives in the case of a rare peptide sensitivity
- Swelling of treated area indicating a possible allergic reaction
- Interaction with other active ingredients such as acids or retinoids that may already be irritating the skin
If any of these reactions occur stop using the product and consult a healthcare professional for guidance.
Comedogenic Rating
Rating: 0/5 (non-comedogenic)
Sh-Polypeptide-60 is a lightweight water-based protein that does not contain oils, fats or waxes that could clog pores. Its large molecular size keeps it on the skin’s surface rather than settling into follicles, so it has virtually no tendency to spark blackheads or breakouts.
Because of this the ingredient is generally considered safe for acne-prone skin.
Formulas that pair the peptide with heavier emollients could raise the overall pore-clogging risk, so always look at the full ingredient list if congestion is a concern.
Summary
Sh-Polypeptide-60 is a lab-crafted copy of human superoxide dismutase 1 that is used in skincare for its skin-conditioning ability. By forming a light protective film, it helps the surface barrier hold moisture, eases tightness and leaves skin feeling smooth.
While not as famous as retinol or vitamin C, the peptide is gaining traction in serums, masks and soothing after-sun gels thanks to its gentle touch and vegan origin.
Current evidence shows it is well tolerated by most skin types, including sensitive and acne-prone skin, with no serious safety flags. Still, skin is personal so do a quick patch test whenever you try a new product that features this peptide.