What Is Sh-Polypeptide-61?
Sh-Polypeptide-61 is a lab-crafted version of Tripartite Motif-Containing Protein 72, a small segment of a naturally occurring human protein. Scientists recreate the polypeptide through controlled biofermentation, usually by inserting the gene that codes for it into yeast or bacteria, then harvesting and purifying the resulting peptide. Because the process is fully synthetic and happens in sterile tanks it avoids animal sourcing and keeps the material consistent from batch to batch.
The cosmetic world became interested in this peptide once researchers noticed its ability to help skin feel firmer and look more refined. Early trials in professional skincare lines showed promising results for improving texture, so formulators began adding it to mainstream products. Today you will most often spot Sh-Polypeptide-61 in anti-aging serums, pore-minimizing toners, firming masks, lightweight moisturizers and post-shave soothing lotions.
Sh-Polypeptide-61’s Cosmetic Benefits/Uses
In skincare formulas Sh-Polypeptide-61 pulls its weight in several ways
- Astringent: Helps tighten the appearance of pores, reduces surface oil and delivers an immediate refreshed feel that many people associate with toned skin
- Skin Conditioning: Supports a smoother, softer texture by binding light moisture to the skin so the surface feels supple rather than dry or tight
- Skin Protecting: Forms a lightweight, breathable film that shields the skin from daily environmental stressors such as dust or pollution particles which can dull the complexion
Who Can Use Sh-Polypeptide-61
Because this peptide is lightweight and oil free it suits most skin types including oily, combination, normal and mildly dry complexions. Those with very dry skin may want to pair it with a richer moisturizer for extra hydration, while highly reactive or allergy-prone skin should introduce any new formula slowly to make sure the full ingredient list is tolerated.
Sh-Polypeptide-61 is produced through biofermentation without animal by-products so it is compatible with vegan and vegetarian lifestyles.
No data points to concerns for women who are pregnant or breastfeeding when Sh-Polypeptide-61 is applied topically in cosmetic concentrations, yet this is not medical advice. Expectant or nursing mothers should review any skincare routine with a qualified physician to be safe.
The peptide does not cause photosensitivity, meaning it will not make skin more prone to sunburn. Standard daytime sun protection is still recommended to guard against routine UV damage.
Sh-Polypeptide-61 plays well with most common actives such as niacinamide, ceramides or gentle exfoliating acids and does not interfere with makeup wear.
Potential Side Effects/Adverse Reactions
Sensitivity to topically applied Sh-Polypeptide-61 varies between individuals. The issues listed below are only potential outcomes and are unlikely for the average user when the ingredient is properly formulated.
- Mild redness or warmth at the application site
- Transient itching or tingling as the product settles
- Localized dryness if the overall formula is low in emollients
- Rare allergic contact dermatitis triggered by a specific peptide sequence or accompanying preservative
If any irritation, swelling or persistent discomfort develops stop using the product and seek advice from a healthcare professional.
Comedogenic Rating
Rating: 0
Sh-Polypeptide-61 is a small, water-soluble peptide that does not contain heavy oils, waxes or fatty acids that can clog pores. Because it sits lightly on the skin and is easily rinsed away during cleansing it earns a non-comedogenic score of 0. This makes it suitable for acne-prone and breakout-prone skin types.
Most formulas use the peptide at very low percentages, further minimizing any risk of pore blockage. If the finished product does cause congestion it is more likely due to other richer ingredients in the blend, not the peptide itself.
Summary
Sh-Polypeptide-61 works as an astringent, skin-conditioning and skin-protecting agent. It gently tightens the look of pores, binds light moisture for a smoother feel and creates a breathable film that shields skin from daily grime and pollution.
The peptide enjoys modest popularity in modern skincare: you will see it mainly in mid to high-end serums, toners and lightweight creams aimed at refining texture and firmness.
Overall safety data are favorable with only rare reports of irritation. Still, every complexion is unique so it is smart to patch test any new product that contains this or any other active before full-face use.