What Is Sh-Polypeptide-62?
Sh-Polypeptide-62 is a lab made version of hepatocyte growth factor, a protein that naturally signals cells to repair and renew themselves. In cosmetics it is produced through bio-engineering: scientists insert the genetic blueprint for the protein into harmless bacteria or yeast, grow the cells in large tanks then purify the resulting peptide. The finished ingredient is a short chain of amino acids small enough to sit on the surface of skin or hair without acting as a drug.
The beauty world first became interested in growth factors in the early 2000s after studies showed they could improve the look of aging skin. Sh-Polypeptide-62 soon found its way into high end spa treatments, and over time into everyday skin and hair care lines where milder but steady results are valued.
Today you will see Sh-Polypeptide-62 in facial serums, sheet masks, leave on moisturizers, scalp tonics, anti aging creams and post-procedure soothing gels. Brands choose it when they want to offer a lightweight yet targeted boost to the skin or hair fiber without heavy oils or silicones.
Sh-Polypeptide-62’s Cosmetic Benefits/Uses
Sh-Polypeptide-62 brings several helpful actions to a formula
- Antioxidant – helps neutralize everyday pollution and sunlight triggered free radicals that can dull skin tone or weaken hair strands
- Hair conditioning – forms a gentle film on the strand surface making hair feel smoother, look shinier and resist breakage from brushing
- Skin conditioning – supports the skin’s own repair signals so the surface appears softer, more even and better hydrated over time
Who Can Use Sh-Polypeptide-62
Because it is lightweight and free of pore clogging oils Sh-Polypeptide-62 suits almost every skin type including oily, dry, combination and sensitive. People dealing with compromised or post-procedure skin often like it because it supports the skin’s own repair messages without adding fragrance or strong acids. There are no known skin types that must avoid it, though anyone with a proven allergy to peptides in general should proceed carefully.
The ingredient is produced by fermenting bacteria or yeast that have been given the gene for hepatocyte growth factor, so no animal tissue is involved. That makes it appropriate for both vegetarians and vegans as long as the finished product has not been tested on animals.
No formal restrictions prevent pregnant or breastfeeding women from using Sh-Polypeptide-62, but safety data during pregnancy are still limited. This text is not medical advice and anyone who is expecting or nursing should show the full ingredient list of any cosmetic product to a qualified healthcare provider before use.
Sh-Polypeptide-62 does not make skin more sensitive to sunlight and can be worn morning or night. It also plays well with most other common actives such as niacinamide, hyaluronic acid, vitamin C and mild exfoliating acids.
Potential Side Effects/Adverse Reactions
Responses to topical Sh-Polypeptide-62 vary from person to person. The issues below are possible yet uncommon when the ingredient is formulated and used correctly.
- Transient redness or warmth
- Mild stinging or itching on sensitive skin
- Contact dermatitis in individuals allergic to peptides or preservative systems used alongside them
- Watery eyes or irritation if the product accidentally gets into the eye area
- Scalp buildup or greasy feel if hair products containing high levels are not rinsed well
If any persistent discomfort or visible reaction occurs stop using the product and consult a healthcare professional or dermatologist for guidance.
Comedogenic Rating
Rating: 0/5 Sh-Polypeptide-62 is a tiny, water soluble peptide with no oily or waxy components so it does not linger inside pores or form a film that traps dead cells. Because it sits on the surface and rinses away easily it carries virtually no risk of clogging pores or triggering whiteheads or blackheads. This makes it a comfortable choice for people prone to acne or breakouts. Only the overall formula can raise the comedogenic potential, so check for heavy plant oils or butters elsewhere on the label.
Summary
Sh-Polypeptide-62 is a lab crafted version of hepatocyte growth factor that acts as an antioxidant, skin conditioner and hair conditioner. By mimicking natural repair signals it helps neutralize free radicals, supports smoother stronger hair and encourages skin to look softer and more hydrated.
The peptide is slowly gaining traction in mid range and prestige products, especially serums and scalp treatments, although it remains less common than classic actives like retinol or vitamin C. Its safety profile is favorable with few reported reactions and no evidence of pore clogging or sun sensitivity. As with any new cosmetic ingredient it is still wise to patch test a small area first to ensure personal tolerance.