What Is Sh-Polypeptide-7 Sh-Oligopeptide-1?
Sh-Polypeptide-7 Sh-Oligopeptide-1 is a lab made fusion peptide built from two smaller peptide sequences, sh-Polypeptide-7 and sh-Oligopeptide-1. Chemists join the genes that code for each part and insert this new gene into harmless strains of E. coli. The bacteria act like tiny factories, churning out the peptide during fermentation. After the cells grow, the peptide is extracted, purified and checked for quality. The finished ingredient is a single chain of 244 amino acids that can form disulfide bridges and sometimes carry sugar groups, features that help it stay stable on skin.
Peptides started gaining attention in skincare in the early 2000s when researchers noticed their ability to signal repair in skin. As labs became better at designing and producing longer, more complex chains, brands began exploring fusion peptides for broader effects. Sh-Polypeptide-7 Sh-Oligopeptide-1 is one of those next-generation options, created to blend the supportive traits of each original peptide.
You will most often see this ingredient in serums, sheet masks, leave-on anti aging lotions and concentrated treatment ampoules aimed at strengthening the skin barrier and reducing early signs of wear. It is usually listed low to mid range on an ingredient list because only a small amount is needed to deliver its benefits.
Sh-Polypeptide-7 Sh-Oligopeptide-1’s Cosmetic Benefits/Uses
This peptide mainly works as a skin protecting agent that helps keep the surface smooth and resilient. By supporting the skin barrier it can reduce moisture loss, fend off irritation from daily stressors and promote a healthier looking complexion over time.
Who Can Use Sh-Polypeptide-7 Sh-Oligopeptide-1
This fusion peptide is considered gentle enough for every skin type. Dry and mature complexions benefit from its barrier supporting action while oily or combination skin can use it without a greasy feel because the peptide itself is lightweight and non comedogenic. Sensitive skin generally tolerates it well although anyone with a known allergy to peptides or fermentation byproducts should proceed with caution.
The ingredient is produced through bacterial fermentation with no animal derived matter so it suits both vegans and vegetarians.
Current research shows no specific risks for pregnant or breastfeeding women when the peptide is used topically. The molecule is large so it is unlikely to enter the bloodstream in meaningful amounts. This is not medical advice and anyone who is pregnant or nursing should clear new skincare products with a qualified healthcare provider.
Sh-Polypeptide-7 Sh-Oligopeptide-1 does not increase photosensitivity so it can be used morning or night. It plays nicely with most common actives including niacinamide and hyaluronic acid making it an easy addition to multi step routines.
Potential Side Effects/Adverse Reactions
Reactions to topical Sh-Polypeptide-7 Sh-Oligopeptide-1 differ from person to person. The following is a list of potential side effects that could occur even though they are uncommon when the ingredient is formulated and used correctly.
Redness or mild irritation in very sensitive skin
Allergic contact dermatitis in individuals with a peptide or preservative allergy
Breakouts if the finished product is heavy in occlusive carriers
Temporary stinging when applied to freshly exfoliated or compromised skin
If any of these effects appear stop using the product and consult a medical professional.
Comedogenic Rating
Rating: 0/5
Sh-Polypeptide-7 Sh-Oligopeptide-1 is a large water-soluble peptide that does not form film-forming oils or waxes on the surface of the skin. Because it cannot clog pores on its own and is usually included at very low percentages, its inherent comedogenicity is considered negligible.
Suitable for acne-prone or breakout-prone skin.
Only the finished formula’s texture and supporting ingredients (like heavy butters or silicones) could influence the likelihood of clogged pores, not the peptide itself.
Summary
Sh-Polypeptide-7 Sh-Oligopeptide-1 is a lab crafted fusion peptide that helps protect the skin barrier, limits moisture loss and keeps the surface calm and resilient. It does this by mimicking natural skin signaling molecules that encourage repair and by forming a lightweight protective layer that holds water in.
The ingredient is still a niche addition rather than a blockbuster, found mainly in higher end serums, ampoules and sheet masks aimed at early anti-aging support.
Current evidence points to a strong safety profile with low irritation risk and no comedogenicity concerns, yet it is always smart to patch test any new product to catch personal sensitivities before full use.