What Is Sh-Polypeptide-7 Sh-Polypeptide-94 Sh-Polypeptide-95?
Sh-Polypeptide-7 Sh-Polypeptide-94 Sh-Polypeptide-95 is a lab made fusion peptide used in beauty products to support healthy looking hair and skin. Scientists created it by joining the DNA sequences for three individual peptides, then having Chinese hamster ovary cells read that DNA and build a single chain of 436 amino acids. The finished chain can form small links called disulfide bonds and may carry sugar groups, both of which help it fold into a stable shape that the skin can recognize.
The idea of using bio-engineered peptides in cosmetics took off in the early 2000s when brands began looking for gentler ways to signal skin to renew itself. Borrowing methods from medical research, chemists learned they could guide cells to produce custom sequences with specific care benefits. This triple peptide is one of the newer results of that work, offering a blend of actions drawn from its three parent molecules.
Manufacturing starts with a computer designed gene that is inserted into the ovary cells. The cells are grown in large fermentation tanks, then the peptide is purified, filtered and blended with stabilizing ingredients so it can slip into creams or serums without breaking down.
You will usually find Sh-Polypeptide-7 Sh-Polypeptide-94 Sh-Polypeptide-95 in leave-on products that aim to smooth, protect or rejuvenate, such as lightweight anti-aging serums, moisturizers, eye creams, overnight masks, scalp tonics and strengthening hair conditioners.
Sh-Polypeptide-7 Sh-Polypeptide-94 Sh-Polypeptide-95’s Cosmetic Benefits/Uses
This ingredient brings several helpful actions to a formula
- Hair conditioning – coats strands to reduce roughness, improve slip and add a soft touch without a heavy feel
- Skin conditioning – helps skin feel smoother and more supple by supporting its natural moisture balance and surface renewal
- Skin protecting – forms a light barrier that shields skin from daily stress like pollution or dryness, which can keep the complexion looking fresher over time
Who Can Use Sh-Polypeptide-7 Sh-Polypeptide-94 Sh-Polypeptide-95
Most skin types, including dry, normal, combination and oily, can comfortably use this peptide because it is lightweight and non occlusive. Sensitive skin generally tolerates it as well thanks to its gentle, barrier friendly nature, though anyone prone to reactions with new proteins should proceed with extra care.
The ingredient is produced in a laboratory using a long established line of Chinese hamster ovary cells. Although no animal tissue is present in the finished material, the use of an animal derived cell line means strict vegans may prefer to avoid it while many vegetarians consider it acceptable. If cruelty free certification is important to you, check whether the finished product has been third party verified.
Current research suggests that this large peptide stays on the surface of skin and hair, so it is unlikely to enter the bloodstream. Because formal safety data in pregnant or breastfeeding women is limited, it is best to review any product containing it with a healthcare professional before use. This information is not medical advice, just a precautionary reminder.
Sh-Polypeptide-7 Sh-Polypeptide-94 Sh-Polypeptide-95 does not increase photosensitivity, so it will not make skin more prone to sunburn. It also plays well with common actives such as niacinamide, ceramides and mild acids, though extreme heat can break the peptide down, so store products in a cool place.
Potential Side Effects/Adverse Reactions
Responses to topical Sh-Polypeptide-7 Sh-Polypeptide-94 Sh-Polypeptide-95 differ from person to person. The points below outline potential effects, but they are uncommon when the ingredient is used correctly in a well formulated product.
- Temporary redness or warmth on application
- Mild itching or tingling, especially on compromised skin
- Rare allergic contact dermatitis in individuals sensitized to proteins or fermentation residues
- Eye irritation if the product accidentally migrates into the eyes
- Product spoilage caused by improper storage, which could lead to skin irritation
If any discomfort, persistent redness or swelling occurs discontinue use and seek advice from a healthcare professional.
Comedogenic Rating
Rating: 0 / 5 (non-comedogenic)
Sh-Polypeptide-7 Sh-Polypeptide-94 Sh-Polypeptide-95 is a large, water soluble protein that sits on the surface without plugging pores. It contains no heavy oils, waxes or fatty acids that typically trigger breakouts, so the risk of forming comedones is extremely low.
This makes the ingredient generally suitable for people who are prone to acne or congestion. Keep in mind that the overall pore friendliness of a finished product also depends on the rest of the formula.
Summary
Sh-Polypeptide-7 Sh-Polypeptide-94 Sh-Polypeptide-95 is a lab designed fusion peptide that conditions hair, smooths and protects skin by forming a light breathable film and supporting the skin’s natural moisture barrier. Its gentle surface action helps strands feel softer and leaves skin looking refreshed and resilient.
While still a niche addition, its presence is slowly growing in leave-on serums, creams and scalp treatments as brands look for sophisticated yet mild actives.
Current data shows it to be well tolerated with minimal risk of irritation or clogged pores when used as directed. As with any new cosmetic ingredient it is wise to carry out a small patch test first to make sure your skin is happy with the formula.