What Is Sh-Polypeptide-70?
Sh-Polypeptide-70 is a lab-engineered chain of amino acids designed to mimic a portion of the bone morphogenetic protein receptor 1A, a naturally occurring protein involved in cell communication. Because it is a synthetic analog rather than an extract from animals or plants, it is produced through biofermentation: scientists insert a specific gene sequence into harmless bacteria or yeast, let the microorganisms grow in controlled tanks, then isolate and purify the resulting peptide. This controlled process ensures consistent quality and reduces the risk of contamination. The cosmetic industry first became interested in bio-identical peptides like Sh-Polypeptide-70 in the early 2000s when research showed these small proteins could help signal skin cells to behave in a more youthful manner. Today you can find Sh-Polypeptide-70 in serums, anti-aging creams, sheet masks, eye treatments and high-performance moisturizers where it plays a supportive role in overall skin health.
Sh-Polypeptide-70’s Cosmetic Benefits/Uses
Formulators value Sh-Polypeptide-70 for one principal reason: skin conditioning. By helping skin cells maintain a healthy environment, the peptide can improve softness, boost suppleness and lend a smoother look to the complexion, which in turn enhances the overall feel and performance of the product it is blended into.
Who Can Use Sh-Polypeptide-70
Sh-Polypeptide-70 is generally considered friendly for all skin types, including dry, oily, combination and sensitive skin, since peptides tend to be mild and non-comedogenic. People with very reactive or allergy-prone skin should still keep an eye on the full ingredient list of a product to make sure no other components are problematic for them.
Because the peptide is made through biofermentation rather than harvested from animals, it is suitable for both vegans and vegetarians.
Current research has not flagged Sh-Polypeptide-70 as a concern for women who are pregnant or breastfeeding. That said this is not medical advice and anyone who is pregnant or nursing should run any skincare product past a doctor to be on the safe side.
The ingredient does not increase photosensitivity so it can be used day or night without raising the risk of sunburn, though daily sunscreen is still wise for overall skin health.
Potential Side Effects/Adverse Reactions
Side effects and reactions to the topical application of Sh-Polypeptide-70 can vary from person to person. The points below list potential issues yet they are unlikely to be the typical user experience. When the ingredient is formulated correctly most users will not notice any problems.
- Mild redness or warmth at the application site
- Temporary itching or tingling
- Localized rash in people with peptide sensitivities
- Watery or stinging eyes if the formula migrates into the eye area
- Rare allergic contact dermatitis
If any of these reactions occur stop using the product and consult a healthcare professional.
Comedogenic Rating
Rating: 0 / 5
Peptides like Sh-Polypeptide-70 are water soluble, lightweight and do not leave an occlusive film that can block pores. For that reason they sit at the very bottom of the comedogenic scale. This makes the ingredient a safe choice for people who are prone to acne or breakouts.
Because it is usually delivered in serum or gel textures that absorb quickly, the surrounding formula is also unlikely to contribute to congestion, although you should still check the full ingredient list if you are highly breakout prone.
Summary
Sh-Polypeptide-70 is a bioengineered peptide that conditions skin by supporting healthy cell communication which can lead to softer, smoother and more resilient skin. It is not yet a mainstream household name, but it is gaining traction with formulators looking for gentle performance boosters in anti-aging products.
Current data shows the ingredient to be low risk with minimal side effects when used as directed. As with any new skincare product, patch testing is a smart step to confirm personal tolerance.