What Is Sh-Polypeptide-73?
Sh-Polypeptide-73 is a lab engineered version of macrophage colony stimulating factor, a small protein naturally produced by the body to help guide cell activity. In cosmetics it is offered as a synthetic peptide created through recombinant DNA technology, usually by inserting the human gene that codes for this protein into a harmless strain of yeast or bacteria. After controlled fermentation the peptide is separated, purified and gently dried into a stable powder that can be blended into creams and serums.
The idea of adding bio-identical peptides to skin care took off in the early 2000s when researchers showed that certain growth factors could improve the look of aging skin. Sh-Polypeptide-73 entered the scene as formulators searched for proteins that signal repair yet remain small enough to slip into topical formulas without losing activity. Because the molecule mimics a natural skin messenger it has gained a place in premium products that focus on barrier support and recovery.
Manufacturers typically dissolve the purified peptide in a buffered solution, add protective carriers like glycerin then filter the mix to maintain sterility. The ready-to-use ingredient is supplied to brands as a clear liquid or freeze-dried powder that is rehydrated during production.
You will most often spot Sh-Polypeptide-73 in soothing post-procedure gels, overnight masks, anti-aging serums, barrier-repair moisturizers and specialty ampoules aimed at stressed or sensitive skin.
Sh-Polypeptide-73’s Cosmetic Benefits/Uses
This peptide’s job in a formula centers on one main benefit.
Skin protecting: By acting as a communication molecule it encourages a balanced skin response to daily stress. The peptide helps maintain a healthy barrier, keeps surface inflammation in check and supports the skin’s own renewal process. Formulators add it to products that promise calmness, increased resilience and an overall smoother appearance.
Who Can Use Sh-Polypeptide-73
Because it is a calming barrier-support peptide, Sh-Polypeptide-73 is generally suitable for all skin types including dry, oily, combination and especially sensitive or post-procedure skin that needs extra care. Extremely compromised skin with open lesions should wait until the surface has closed before applying any cosmetic peptide so the area can heal without added variables.
The peptide is produced through fermentation in yeast or bacteria so no animal-derived material is used during manufacture. That makes it an ingredient most vegans and vegetarians can feel comfortable choosing, provided the finished formula does not contain other animal ingredients.
Pregnant or breastfeeding users are not known to face added risk from topical Sh-Polypeptide-73 because the molecule is large enough to stay near the surface and acts locally. Still this is not medical advice and anyone who is expecting or nursing should show the full ingredient list of any product to their doctor first to be extra safe.
The peptide does not make skin more sensitive to sunlight and can be used morning or night without elevating the need for sunscreen beyond the normal daily recommendation.
Potential Side Effects/Adverse Reactions
Reactions to topical Sh-Polypeptide-73 vary from person to person. The points below describe potential issues that could arise, though they are uncommon when the ingredient is properly formulated and used as directed.
- Transient redness or warmth
- Mild itching or stinging upon application
- Allergic contact dermatitis in individuals sensitive to the peptide or other formula components
- Breakouts in acne-prone skin if the overall product is overly rich or occlusive
- Interaction with prescription wound treatments if used on freshly treated skin without professional guidance
If any irritation or other negative effect appears stop using the product and consult a healthcare professional or dermatologist for guidance.
Comedogenic Rating
Rating: 0 / 5
Sh-Polypeptide-73 is a water-soluble peptide with no oily or waxy residues that could clog pores, so it earns a solid zero on the comedogenic scale. It is normally delivered in lightweight serums or gels that rinse off skin easily and leave minimal film.
That makes the ingredient entirely suitable for people who are prone to acne or breakouts.
Keep in mind the overall formula still matters. If the product pairs this peptide with heavy butters or rich occlusives, those other ingredients could raise the comedogenic potential even though the peptide itself does not.
Summary
Sh-Polypeptide-73 is a lab-made version of macrophage colony stimulating factor that mainly acts as a skin-protecting signal molecule. Once applied it helps calm surface irritation, supports barrier repair and promotes a balanced renewal rhythm, leaving skin more resilient and comfortable.
The peptide enjoys moderate popularity, most common in higher-end recovery serums and post-procedure treatments rather than mass-market lines, largely because of its precision manufacturing cost.
Safety data show low irritation and no photosensitivity, so it is generally considered a gentle option for daily use. As with any new skincare ingredient it is smart to perform a small patch test when trying a product that contains Sh-Polypeptide-73, especially if your skin is sensitive or you already follow a prescription routine.