What Is Sh-Polypeptide-74?
Sh-Polypeptide-74 is a lab made version of Nerve Growth Factor-2, a small chain of amino acids that can send helpful signals to skin cells. Scientists create it with fermenting bacteria or yeast that have been given a copy of the human NGF-2 gene. After the cells grow in stainless-steel tanks, the peptide is filtered and purified so it is clean and ready for skincare.
The search for gentler anti-aging ingredients led researchers in the early 2010s to explore growth factors. Sh-Polypeptide-74 soon found a place in cosmetic labs because it offered many of the same perks as natural growth factors without needing animal or human extracts. Today you will most often see it in lightweight serums, sheet masks, eye creams, concentrated ampoules, and premium moisturizers that focus on firming and smoothing the complexion.
Sh-Polypeptide-74’s Cosmetic Benefits/Uses
In formulas this peptide serves one main purpose that can make a visible difference to skin.
Skin conditioning: Sh-Polypeptide-74 helps keep the surface of the skin soft and supple. By encouraging a healthy environment for skin cells it can support a smoother texture and a fresher, more even look, which is why brands often include it in products that target fine lines or dullness.
Who Can Use Sh-Polypeptide-74
This gentle peptide is generally suitable for all skin types, including dry, normal, combination, oily and even sensitive skin, because it lacks fragrance and harsh exfoliating action. People with extremely compromised or broken skin barriers should wait until their skin has calmed before introducing any new active, Sh-Polypeptide-74 included.
Because the peptide is produced through fermentation without animal tissues, it is considered vegan and vegetarian friendly. Always double-check the full ingredient list of the finished product, as other components like beeswax or collagen may alter the overall status.
No specific warnings link Sh-Polypeptide-74 to problems during pregnancy or breastfeeding, and its large molecular size means very little would be expected to pass into the bloodstream. Still, this is not medical advice; anyone who is pregnant or nursing should show the product to a qualified healthcare provider before adding it to a routine.
The peptide does not make skin more sensitive to sunlight, so it is not known to cause photosensitivity. Daily sunscreen is still recommended for overall skin health.
Potential Side Effects/Adverse Reactions
Side effects and reactions to the topical use of Sh-Polypeptide-74 can vary from person to person. The points below outline potential issues, though most users will not experience them when the ingredient is properly formulated and applied.
- Mild redness or warming sensation shortly after application
- Transient itching or tingling, especially on very sensitive skin
- Localized rash or hives in individuals allergic to the peptide or another formula component
- Increased irritation when layered with highly acidic or strong exfoliating products
If any persistent discomfort, swelling or rash appears, stop using the product and consult a healthcare professional.
Comedogenic Rating
Rating: 0/5 – Sh-Polypeptide-74 is a water-soluble peptide that contains no heavy oils, waxes or fatty acids, so it does not block pores or trap sebum. Its large molecular size also keeps it on the skin surface rather than inside follicles, further reducing any clogging risk. This makes the ingredient well suited for people who are prone to acne or breakouts.
While the peptide itself is non-comedogenic, finished products may include other components like rich plant butters, silicones or fatty alcohols that raise the overall pore-clogging potential. Always consider the full formula if you are extremely breakout-prone.
Summary
Sh-Polypeptide-74 is a lab-crafted version of Nerve Growth Factor-2 that works mainly as a skin-conditioning agent. By delivering cell-signaling cues it supports healthier surface activity, helping skin look smoother, firmer and more even. These benefits explain why brands slot it into serums, eye creams and premium masks aimed at fine lines or dullness.
The peptide enjoys moderate popularity: it is not as famous as retinol or vitamin C, yet it has a loyal following in higher-end K-beauty and cosmeceutical lines where gentle anti-aging actives are prized.
Safety data and real-world use show Sh-Polypeptide-74 to be low risk for irritation, photosensitivity and pore clogging. Most people tolerate it well, but skin is individual, so it is wise to patch test any new product that contains the peptide before applying it to the entire face.