What Is Sh-Polypeptide-77?
Sh-Polypeptide-77 is the cosmetic name for glutaredoxin-1, a small protein naturally found in the body where it helps keep cells in good working order. In skin care it is made through biotechnology: scientists insert the genetic code for human glutaredoxin-1 into harmless laboratory bacteria or yeast. These microorganisms are grown in steel tanks, they produce the protein, then it is carefully purified, filtered and dried into a stable powder that can be mixed into creams and serums.
Interest in using glutaredoxin-1 on skin grew in the early 2000s when researchers looked for gentler options to support the skin’s own defense systems. Its lab production is animal-free and consistent in quality, which made it appealing to cosmetic chemists. You will most often see Sh-Polypeptide-77 in anti-aging moisturizers, firming masks, brightening serums and leave-on treatments aimed at tired or stressed skin.
Sh-Polypeptide-77’s Cosmetic Benefits/Uses
Sh-Polypeptide-77 is mainly valued for one key role in formulas.
Skin conditioning: By supporting the skin’s natural repair processes it helps keep the surface smooth, hydrated and comfortable. Regular use may make skin look fresher and feel softer which is why formulators add it to products that promise renewed or revitalized skin.
Who Can Use Sh-Polypeptide-77
Because it is lightweight and non greasy, Sh-Polypeptide-77 suits most skin types including dry, normal, combination sensitive and mature skin. Oily and acne prone users can also apply it since it does not clog pores or add extra oil.
The ingredient is produced through fermentation in controlled lab conditions with no animal derived materials, so it is suitable for vegetarians and vegans.
No data points to problems for pregnant or breastfeeding women when the peptide is used topically at typical cosmetic levels, but this is not medical advice. Anyone expecting or nursing should show the full product label to a qualified healthcare professional before starting use just to be safe.
Sh-Polypeptide-77 does not increase photosensitivity, so standard daytime use is fine with normal sun protection habits.
Potential Side Effects/Adverse Reactions
Responses to any skincare ingredient can differ from one person to another. The points below outline possible but uncommon reactions when Sh-Polypeptide-77 is applied to skin. When used in properly formulated products the average person will not notice these issues.
Skin irritation – mild stinging or burning may appear in very sensitive users
Redness – temporary flushing can occur if the formula contains high levels of actives that boost circulation alongside the peptide
Allergic contact dermatitis – rare protein allergies could lead to itching swelling or tiny bumps
If any unwanted reaction develops discontinue use and consult a medical professional.
Comedogenic Rating
Rating: 0/5 – Sh-Polypeptide-77 is a water-soluble protein that contains no heavy oils waxes or fatty acids that could block pores. It sits lightly on the skin then absorbs or is rinsed away without leaving residue. Because of this it is considered non-comedogenic and should not trigger blackheads or whiteheads.
Suitable for acne-prone and breakout-prone skin.
Formulas that pair the peptide with rich emollients could alter the overall pore-clogging risk, so always check the full ingredient list if congestion is a concern.
Summary
Sh-Polypeptide-77 works as a skin-conditioning agent. By supporting the skin’s natural repair and defense pathways it helps the surface stay smooth hydrated and comfortable which can translate into a fresher healthier look.
It is not yet a household name like retinol or vitamin C but its biotech origin and gentle profile are gaining quiet popularity among brands focused on science-backed anti-aging and barrier care.
Topically applied at cosmetic levels it is considered very safe for regular use with low risk of irritation or allergic reactions. Still, everyone’s skin is unique so patch testing any new product that contains Sh-Polypeptide-77 is a smart precaution.