What Is Sh-Polypeptide-86?
Sh-Polypeptide-86 is a lab made copy of follistatin, a naturally occurring human protein known for its role in skin renewal. Scientists start with a computer generated version of the human follistatin gene, insert it into harmless E. coli bacteria and let the bacteria ferment in large tanks. During fermentation the bacteria read the gene and assemble a single chain of up to 344 amino acids that matches the human protein, complete with any needed disulfide bonds or sugar groups. After the protein is harvested it is purified, filtered and freeze dried into a fine powder that is easy to blend into skin care formulas.
The move from medical research to beauty counters began when studies showed follistatin could help skin cells stay in a balanced, youthful state. Brands looking for gentle age support picked up the technology and reformulated it for topical use. Today Sh-Polypeptide-86 turns up in serums, sheet masks, eye creams, moisturizers and targeted anti aging treatments where it is prized for adding a refined, high tech edge without relying on animal sources.
Sh-Polypeptide-86’s Cosmetic Benefits/Uses
In skin care labels Sh-Polypeptide-86 is listed for one main job, yet that single role can still make a visible difference in a routine.
As a skin conditioning agent, it helps keep the surface feeling soft, supple and comfortable. By supporting the skin’s own proteins it can encourage a smoother look, improve texture after cleansing and leave a hydrated finish that works well under makeup or sunscreen.
Who Can Use Sh-Polypeptide-86
Most people find Sh-Polypeptide-86 gentle enough for daily use. It suits normal, dry, oily and combination skin because it focuses on protein balance rather than oil control or acid exfoliation. Sensitive skin can usually tolerate it too since it does not peel or tingle, though anyone with a known allergy to peptides should stay cautious.
The peptide is grown in a lab using E. coli and is not taken from animals, so it is considered vegan and vegetarian friendly.
Pregnant or breastfeeding users are not generally warned away from topical peptides. The molecule is large and stays on the surface, making absorption into the bloodstream unlikely. Still, this is not medical advice and anyone who is pregnant or nursing should run their whole skin care lineup past a qualified doctor to be safe.
Sh-Polypeptide-86 does not increase photosensitivity. Regular daytime sunscreen is still a good idea but you will not be at extra risk of sunburn because of this ingredient. It also pairs well with common actives like vitamin C, niacinamide and hyaluronic acid without neutralizing them.
Potential Side Effects/Adverse Reactions
Responses to any topical ingredient can differ from one person to another. The points below cover potential side effects that could appear, yet most users will never notice them when the peptide is formulated and used correctly.
- Mild redness or warmth shortly after application
- Temporary stinging on very sensitive skin
- Itching or small hives in cases of peptide allergy
- Interaction with other products if a formula contains high levels of fragrance or alcohol
If any of these reactions occur stop using the product and consult a healthcare professional for guidance.
Comedogenic Rating
Rating: 0/5
Sh-Polypeptide-86 is a large water soluble peptide with no oily or waxy residues so it does not clog pores. Because it stays on the skin surface and lacks heavy lipids its chance of blocking follicles is extremely low.
That makes it a suitable option for people who are prone to acne or frequent breakouts.
Keep in mind that finished products may still include other pore clogging ingredients, so always check the full ingredient list.
Summary
Sh-Polypeptide-86 is a lab made version of follistatin that conditions the skin by supporting its own proteins. When added to a formula it helps the surface stay smooth hydrated and comfortable while fitting easily alongside daily actives like vitamin C or niacinamide.
The peptide shows up mostly in higher end serums and targeted anti aging lines, making it a growing but still niche addition compared with big names like retinol or hyaluronic acid.
Overall safety is considered high since the molecule is large, vegan friendly and unlikely to penetrate deeply. Side effects are rare yet as with any new skincare ingredient it is smart to patch test first to rule out personal sensitivity.