What Is Sh-Polypeptide-92?
Sh-Polypeptide-92 is a lab-created version of Bone Morphogenetic Protein 11, also called Growth Differentiation Factor 11. In simple terms it is a string of amino acids modeled after a protein naturally found in the body, then produced through biotechnology. Scientists insert the gene that codes for BMP-11 into harmless yeast or bacteria, let the microbes grow in large stainless-steel tanks, then harvest and purify the protein. Once purified it is blended with stabilizers so it can mix smoothly into creams and serums.
The interest in BMP-11 started in regenerative research, where it was studied for its role in cell renewal. As skin care brands searched for new ways to support a fresher appearance they turned to smaller, cosmetic-grade versions of such proteins. Sh-Polypeptide-92 made its commercial debut in high-end anti-aging lines in the early 2010s and is now found in a wider range of products.
You will most often see this ingredient in firming serums, revitalizing eye creams, overnight masks, leave-on moisturizers and concentrated ampoules aimed at dull or mature skin. Because it is water soluble it suits lightweight gels as well as richer emulsions.
Sh-Polypeptide-92’s Cosmetic Benefits/Uses
In cosmetics Sh-Polypeptide-92 is classified as a skin-conditioning agent. It helps the formula support a smoother, healthier-looking surface by signaling the skin to stay balanced and by improving the feel of the product on application. Regular use can translate into a softer texture, better hydration retention and an overall refreshed appearance.
Who Can Use Sh-Polypeptide-92
Sh-Polypeptide-92 is gentle enough for most skin types. Dry, normal or oily skin can all benefit because the peptide is water based and lightweight, yet it also helps hold moisture. Sensitive skin usually tolerates it well since it is non-acidic and fragrance free, though people with an already damaged barrier may want to introduce it slowly to avoid any extra stress.
The ingredient is produced through fermentation in yeast or bacteria, not taken from animals, so it is suitable for both vegans and vegetarians.
There is no specific research showing harm to pregnant or breastfeeding women when Sh-Polypeptide-92 is used topically, but studies are limited. This information is not medical advice, so anyone who is expecting or nursing should ask a doctor before adding new skincare products.
Sh-Polypeptide-92 does not make skin more sensitive to sunlight and can be worn during the day without raising the risk of sunburn. As with any routine, daily sunscreen is still recommended.
Potential Side Effects/Adverse Reactions
Reactions to topical Sh-Polypeptide-92 differ from person to person. The points below outline possible side effects, but most users will not experience them when the product is well formulated and used as directed.
- Temporary redness or warmth a brief flush may appear right after application, especially on sensitive skin
- Mild itching or tingling usually subsides within minutes but can feel uncomfortable for some users
- Rare allergic contact dermatitis manifests as persistent redness, swelling or small bumps in people who develop an allergy to the peptide or another ingredient in the formula
- Breakouts linked to other ingredients acne-prone individuals might react to heavy oils, silicones or waxes in the finished product rather than to the peptide itself
If any of these effects persist or worsen stop using the product and seek advice from a healthcare professional.
Comedogenic Rating
Rating: 0 out of 5. Sh-Polypeptide-92 is a small, water-soluble protein that does not contain heavy oils or waxes, so it does not block pores. Because the molecule stays on the skin surface and rinses off easily during cleansing it earns the lowest possible score for clogging potential. This makes it a safe pick for people who are prone to acne or frequent breakouts. As always the final product formula matters, so rich creams that include butters or thick silicones could still trigger blemishes even if the peptide itself does not.
Summary
Sh-Polypeptide-92 is a lab-made version of Bone Morphogenetic Protein 11 used in skincare to condition the skin. It supports a smoother feel and helps skin hold on to moisture by sending gentle signals that keep surface cells balanced. Thanks to its lightweight, water-based nature it fits well in serums, gels and creams without making them greasy. While once limited to pricey anti-aging lines, it now shows up in a wider range of products as brands look for new peptide options.
The ingredient rates as low risk for irritation or pore clogging and is suitable for most skin types, including sensitive or acne-prone skin. Serious reactions are rare, yet trying any new product on a small patch of skin first is a smart habit to make sure it plays nicely with your individual skin chemistry.