What Is Sh-Polypeptide-95?
Sh-Polypeptide-95 is a lab engineered fragment of the human immunoglobulin G4 (IGHG4) protein. Because it mirrors a sequence already found in the body, the skin recognizes it as friendly which can make it gentle and well tolerated. Most suppliers create it with biotechnology, starting with a small piece of DNA that carries the IGHG4 code. This DNA is introduced into a fermenting microorganism, often a strain of yeast or bacteria, which then produces the peptide in controlled vats. After fermentation, the peptide is filtered, purified and blended into a liquid solution that cosmetic chemists can measure with precision.
The use of bio-designed peptides in beauty formulas took off in the early 2000s when advances in fermentation lowered costs and improved purity. Sh-Polypeptide-95 followed this trend, moving from medical research into skin care after formulators noticed its ability to keep skin proteins in good condition. Today you will most often spot it in anti-aging serums, lightweight moisturizers, sheet masks, revitalizing ampoules and targeted eye treatments.
Sh-Polypeptide-95’s Cosmetic Benefits/Uses
This ingredient is prized for one key role in skin care formulations.
Skin conditioning: Sh-Polypeptide-95 helps maintain a soft, smooth surface by supporting the skin’s own protein network. When added to a formula it can improve the feel of the product, boost a healthy-looking glow and assist in keeping the skin barrier hydrated and resilient over time.
Who Can Use Sh-Polypeptide-95
Because Sh-Polypeptide-95 is designed to imitate a peptide the body already recognizes, it tends to suit most skin types including dry, normal, combination and oily skin. Sensitive skin usually tolerates it as well since the molecule is gentle and free of common irritants. There is no evidence that it worsens acne or rosacea.
The peptide is produced in fermentation tanks without animal-derived raw materials so formulations containing it are typically vegan and vegetarian friendly. Always check the full ingredient list of the finished product to be sure other components also meet personal standards.
Current research shows no specific risks for pregnant or breastfeeding women when the ingredient is applied topically in cosmetic concentrations. That said, this is not medical advice and anyone who is pregnant or nursing should have their healthcare provider review any skincare product they plan to use.
Sh-Polypeptide-95 does not increase photosensitivity so it can be used morning or night. Routine daytime sunscreen is still recommended for overall skin health.
Potential Side Effects/Adverse Reactions
Responses to topical Sh-Polypeptide-95 vary from person to person. The following is a list of potential side effects that could occur even though most users experience none of them when the ingredient is formulated and used correctly.
- Mild redness or warmth at the application site
- Itching or transient tingling
- Rare allergic contact dermatitis in those with peptide sensitivities
- Interaction with other active ingredients that may amplify irritation, such as high-strength exfoliating acids
If any of these effects occur, discontinue use and consult a qualified healthcare professional.
Comedogenic Rating
Rating: 0 (non-comedogenic)
Sh-Polypeptide-95 is a large water-soluble peptide that does not clog pores or leave an occlusive film on the skin. It contains no oils, waxes or fatty acids that typically trigger breakouts which is why formulators classify it as non-comedogenic.
Suitable for acne-prone and breakout-prone skin.
As with any ingredient, the finished product’s overall formula matters; heavy emollients, rich butters or silicones paired with the peptide could still cause congestion in some users.
Summary
Sh-Polypeptide-95 is a bio-designed fragment of the IGHG4 protein that conditions skin by supporting its natural protein network, improving smoothness and helping the barrier stay hydrated and resilient. Its gentle nature, vegan sourcing and compatibility with most skin types have earned it a place in modern serums, masks and eye treatments, although it is still a niche peptide compared with well-known favorites like hyaluronic acid or niacinamide.
Current data shows it is safe for topical use with very low risk of irritation or pore clogging. Even so, anyone trying a new product that contains Sh-Polypeptide-95 should perform a quick patch test to make sure their skin agrees with the full formulation.