What Is Sh-Tetrapeptide-2?
Sh-Tetrapeptide-2 is a lab-made fragment of a human protein called Interleukin 1 Receptor Type 1. The fragment is made up of just four amino acids – arginine, asparagine, lysine and valine – that are arranged in the same order they appear in the full-length protein. Because it is produced synthetically, the ingredient is vegan friendly and free of contaminants sometimes found in animal-derived materials.
This peptide first attracted interest when scientists studying skin aging noticed that short sequences taken from larger proteins could help the skin look firmer and more resilient. Manufacturers soon began creating Sh-Tetrapeptide-2 in the lab using solid-phase peptide synthesis, a precise step-by-step process that links amino acids together in the right order. After purification and quality checks, the finished powder is blended into cosmetic bases.
You will usually see Sh-Tetrapeptide-2 in leave-on products that target signs of aging. Common formats include serums, lightweight moisturizers, sheet masks, eye creams and neck creams. Brands often pair the peptide with hydrators like hyaluronic acid or barrier-supporting lipids to round out an anti-aging formula.
Sh-Tetrapeptide-2’s Cosmetic Benefits/Uses
In skin care, Sh-Tetrapeptide-2 is valued for one primary role.
Skin conditioning: By helping the skin’s surface feel smoother and appear more elastic, the peptide gives formulas a rejuvenating edge. Regular use can support a firmer look, soften the feel of rough areas and enhance overall texture so skin appears healthier and more youthful.
Who Can Use Sh-Tetrapeptide-2
This peptide is gentle enough for most skin types, including dry, normal, combination and oily. People with very sensitive or reactive skin can usually tolerate it because it does not exfoliate or strongly stimulate the skin. Those with a known allergy to any of its four amino acids should avoid it, though such allergies are rare.
Because Sh-Tetrapeptide-2 is made entirely in the lab and contains no animal‐derived material, it suits both vegans and vegetarians.
Current data show no specific risks for pregnant or breastfeeding women when using products with Sh-Tetrapeptide-2. Still, this is not medical advice and anyone who is expecting or nursing should check with a doctor before adding new skin care, just to be safe.
The peptide does not increase photosensitivity, so it will not make skin more prone to sunburn. Daily sunscreen is still advised for overall skin health.
Potential Side Effects/Adverse Reactions
Responses to topical Sh-Tetrapeptide-2 vary from person to person. The effects listed below are possible but uncommon when the ingredient is used in a well-formulated product.
- Mild redness
- Transient tingling or warmth at the application site
- Minor itching
- Rare allergic contact dermatitis in those sensitive to one of the amino acids
If any of these reactions occur stop using the product and consult a healthcare professional if symptoms persist.
Comedogenic Rating
Rating: 0/5
Sh-Tetrapeptide-2 is a tiny water-soluble molecule that contains no oils, waxes or heavy emollients so it does not block pores. For that reason formulators use it freely in products aimed at all skin types, including blemish-prone skin. Overall it is considered safe for those who struggle with acne or frequent breakouts.
As always the final product formula matters. If the peptide is blended into a rich cream packed with pore-clogging oils the finished product could still trigger spots, but the peptide itself will not.
Summary
Sh-Tetrapeptide-2 is a lab-crafted four-amino-acid fragment that conditions skin, lending a firmer feel and smoother texture. By mimicking a tiny part of a natural human protein it helps skin look more elastic and resilient.
The peptide is not yet a household name like retinol or vitamin C but it is gaining steady traction in niche anti-aging serums, eye treatments and sheet masks thanks to its gentle profile and vegan status.
Current research and real-world use show it to be very safe with only rare mild reactions reported. Still, whenever you try a new formula it is smart to patch test first to check for any personal sensitivities.