What Is Sh-Tetrapeptide-38 Trifluoroacetate?
Sh-Tetrapeptide-38 Trifluoroacetate is a lab made copy of a tiny segment of the human Stem Cell Factor protein. While the full protein contains up to 273 amino acids this fragment holds just four, arranged from aspartic acid, leucine and lysine. Turning the peptide into its trifluoroacetate salt keeps it stable and easy to blend into water based formulas.
The ingredient grew out of advances in biomimetic peptides during the early 2000s when researchers looked for shorter protein fragments that could signal skin cells in a safer more controllable way than whole growth factors. Solid phase peptide synthesis allows chemists to build the chain one amino acid at a time on a resin, after which it is cleaved, purified and paired with trifluoroacetic acid to create a white crystalline powder that dissolves quickly in cosmetic bases.
Because it targets the look of skin firmness and resilience you will most often spot Sh-Tetrapeptide-38 Trifluoroacetate in anti-aging serums, firming eye creams, concentrated ampoules, sheet masks and premium moisturizers. Brands include it at low percentages, usually below 0.5 percent, alongside hydrators and antioxidants to round out their rejuvenating blends.
Sh-Tetrapeptide-38 Trifluoroacetate’s Cosmetic Benefits/Uses
In topical skincare formulas this peptide is used for one core purpose.
Skin conditioning: By mimicking natural signaling molecules the peptide helps encourage fresh collagen and other support proteins, which can improve skin elasticity, smooth out the appearance of fine lines and leave skin feeling softer and more supple.
Who Can Use Sh-Tetrapeptide-38 Trifluoroacetate
This peptide is gentle enough for most skin types including normal, dry, oily and combination skin because it focuses on supporting the skin’s own proteins rather than exfoliating or disrupting the barrier. Sensitive skin usually tolerates it well but people prone to peptide allergies should stay alert for any discomfort.
The ingredient is made entirely in a lab with no animal-derived constituents so it suits both vegetarians and vegans.
No studies flag special concerns for pregnant or breastfeeding women when the peptide is applied topically at cosmetic levels. Still, this is not medical advice and anyone who is expecting or nursing should have their doctor review all skincare products they use.
Sh-Tetrapeptide-38 Trifluoroacetate does not make skin more reactive to sunlight and does not replace daily sunscreen for UV protection.
Potential Side Effects/Adverse Reactions
Individual responses to Sh-Tetrapeptide-38 Trifluoroacetate can differ. The points below outline potential side effects but most users experience none when the ingredient is properly formulated and used as directed.
- Mild redness or warmth where applied
- Itching or tingling, especially on very sensitive skin
- Rare allergic contact dermatitis marked by swelling or rash
- Eye irritation if the product migrates into the eyes
If any persistent discomfort or irritation develops stop using the product and consult a healthcare professional.
Comedogenic Rating
Rating: 0/5 (non-comedogenic)
Sh-Tetrapeptide-38 Trifluoroacetate is a small, water-soluble peptide with no oily or waxy components so it does not sit in pores or form a film that traps sebum and debris. Because it is used at very low concentrations and rinses away easily during cleansing the risk of clogging pores is practically zero.
That makes the ingredient perfectly fine for skin that is prone to acne or breakouts. The only caveat is that overall formula counts: heavy creams or occlusive oils in the same product could still cause congestion even if the peptide itself does not.
Summary
Sh-Tetrapeptide-38 Trifluoroacetate is a lab-crafted fragment of the Stem Cell Factor protein that acts as a skin-conditioning signal peptide. By nudging fibroblasts to produce fresh collagen and other support proteins it helps improve firmness, smooth fine lines and leave skin feeling more resilient.
While not yet a household name, it is quietly gaining traction in higher-end serums and eye creams where brands look for gentle alternatives to retinoids and acids.
Current data shows it is safe for the vast majority of users with minimal irritation risk, no photosensitivity and no comedogenicity. As with any new skincare ingredient it is smart to patch test a product before applying it to the entire face, especially if you have a history of sensitivities.