What Is Shikimoyl Hexapeptide-48?
Shikimoyl Hexapeptide-48 is a hybrid molecule created when shikimic acid, a naturally occurring substance most famously sourced from star anise, is chemically linked to a chain of six amino acids known as Hexapeptide-48. By marrying a plant derived acid with a lab designed peptide, chemists get a compound that blends botanical resilience with targeted skin benefits.
Interest in peptide technology took off in the early 2000s when researchers showed that short chains of amino acids could signal skin cells to behave in a younger looking way. Around the same time shikimic acid was gaining attention for its antioxidant capability. Formulators eventually combined the two, leading to the launch of Shikimoyl Hexapeptide-48 in high end skincare aimed at defending skin from everyday stress.
Production starts with the extraction of shikimic acid from star anise seeds or through bio-fermentation of glucose. Separately, the six specific amino acids that form Hexapeptide-48 are synthesized under controlled lab conditions. The two components are then reacted to form a stable bond, purified, dried into a fine powder and finally dispersed in a cosmetic-grade solvent for easy inclusion in formulas.
You will usually find Shikimoyl Hexapeptide-48 in lightweight serums, anti aging moisturizers, sheet masks, eye creams and leave on treatments designed to shield skin from pollution and early signs of aging.
Shikimoyl Hexapeptide-48’s Cosmetic Benefits/Uses
In skincare formulations Shikimoyl Hexapeptide-48 pulls double duty by protecting skin and boosting its resilience.
- Antioxidant: Helps neutralize free radicals generated by UV light and pollution which in turn can minimize the look of premature lines and uneven tone
- Skin protecting: Supports the skin barrier so moisture stays in and irritants stay out leaving the complexion calmer and better hydrated
Who Can Use Shikimoyl Hexapeptide-48
This multitasking peptide suits most skin types including normal, dry, combination and oily because it is lightweight and non occlusive. Sensitive skin generally tolerates it well thanks to its barrier supportive action though anyone with a known allergy to star anise derivatives should approach with caution.
The molecule is produced from plant sourced shikimic acid and lab made amino acids with no animal derived components or by products which makes it suitable for vegans and vegetarians provided the finished formula also aligns with their values.
No data suggest that topical Shikimoyl Hexapeptide-48 poses a risk during pregnancy or while breastfeeding. Still this is not medical advice and anyone expecting or nursing should discuss any skincare product with their healthcare provider before use.
The ingredient does not increase photosensitivity so it can be applied morning or night although daily sunscreen remains essential for overall skin health.
Potential Side Effects/Adverse Reactions
Individual responses to Shikimoyl Hexapeptide-48 can vary. The following are potential but uncommon effects when the ingredient is applied topically in a properly formulated product.
- Mild redness or warmth especially on very reactive skin
- Transient stinging or tingling that subsides within minutes
- Allergic contact dermatitis in people sensitive to shikimic acid or the preservative system used alongside it
- Interaction with high acid or low pH products which could destabilize the peptide and lead to irritation
If any persistent discomfort or visible irritation occurs discontinue use and seek advice from a qualified healthcare professional.
Comedogenic Rating
Rating: 0 / 5
Shikimoyl Hexapeptide-48 is a water soluble peptide complex with no oily or waxy constituents so it does not clog pores. It sits lightly on the skin and rinses away easily, earning it a non-comedogenic score of zero.
That makes it suitable for people who are prone to acne or frequent breakouts.
As always the finished formula matters; if the product also contains heavy plant oils or butters the overall comedogenicity may rise even though the peptide itself rates zero.
Summary
Shikimoyl Hexapeptide-48 teams antioxidant power from shikimic acid with cell-communicating benefits from a six-amino-acid peptide. Together they help neutralize free radicals, reinforce the moisture barrier and keep skin looking smoother and more resilient.
While still a niche ingredient it is gaining traction in boutique serums and eye creams that target early aging and pollution stress. Formulators like its versatility and consumers appreciate its plant-peptide story.
Current research and user reports show it to be very safe with only rare cases of mild irritation. Even so it is smart to patch test any new product first to make sure your skin agrees with the complete formula.