Sodium Guaiazulene Sulfonate: What Is It, Cosmetic Uses, Benefits & Side Effects

Curious about this ingredient? In this article we're explaining exactly what it is and why it's used within cosmetic formulations.
Updated on: June 30, 2025
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We verify all information on this page using publicly available nomenclature standards from The Personal Care Products Council (PCPC), the European Commission's CosIng database and documentation provided directly by ingredient manufacturers. Our analysis is based on technical data from these sources to ensure accuracy and reliability.

What Is Sodium Guaiazulene Sulfonate?

Sodium guaiazulene sulfonate is a water-soluble salt derived from guaiazulene, the vivid blue hydrocarbon that naturally occurs in chamomile oil and some types of marine algae. In its raw form guaiazulene is lipophilic, but when it undergoes sulfonation and is neutralized with sodium, it becomes the sodium 3,8-dimethyl-5-(isopropyl)-1-azulenesulfonate used in modern skincare. The conversion to a sulfonate salt boosts its stability in water-based formulas and allows it to disperse evenly without leaving oily film.

Guaiazulene itself has been recognized for decades thanks to its calming blue tint, which first made waves in after-sun lotions and bar soaps in the 1950s. Chemists later noticed that sulfonating the molecule made it easier to formulate rinse-off cleansers that needed consistent color and mild surfactant support. Today manufacturers usually produce sodium guaiazulene sulfonate through controlled sulfonation of purified guaiazulene followed by neutralization with sodium hydroxide, filtration and spray-drying into a fine powder that dissolves quickly in water.

You will most often spot this ingredient in foaming facial washes, shower gels, micellar waters, sheet mask essences and some soothing toner formulas. Brands like it because the bright blue hue offers a built-in visual cue of freshness while the sulfonate group helps the finished product rinse clean without residue.

Sodium Guaiazulene Sulfonate’s Cosmetic Benefits/Uses

Formulators rely on sodium guaiazulene sulfonate mainly for its contribution to the cleaning phase of skincare.

Cleansing: The sulfonate head of the molecule acts as a mild anionic surfactant, helping water mix with oil and dirt so they can be lifted from the skin during rinsing. This supports a gentle yet effective cleanse, leaves less film than heavier surfactants and maintains the appealing blue tone that signals freshness to the user.

Who Can Use Sodium Guaiazulene Sulfonate

Sodium guaiazulene sulfonate is considered mild enough for all skin types including sensitive or redness-prone skin because it cleans without stripping the natural moisture barrier. Oily and combination skin benefit from its ability to lift excess sebum while dry skin users appreciate that it does not leave a tight feel. There are no known skin types for which the ingredient is specifically unsuitable when used at the low percentages common in cleansers and toners.

The compound is produced synthetically from guaiazulene that is either isolated from plant sources like chamomile oil or recreated in a lab. No animal-derived materials are needed throughout the process so finished products containing it are generally appropriate for vegans and vegetarians. Still, anyone following a strict cruelty-free lifestyle should confirm that the brand’s overall supply chain aligns with their values.

Current data shows no reason to avoid sodium guaiazulene sulfonate during pregnancy or while breastfeeding because it remains on the surface of the skin and is rinsed away. That said, this is not medical advice and pregnant or nursing individuals should review any new skincare products with their healthcare provider to be safe.

The ingredient does not increase photosensitivity, meaning it will not make skin more prone to sunburn. It also does not typically stain skin or clothing once properly diluted in a finished formula. Overall it is a low-risk option for those seeking a gentle blue-tinted cleanser or toner.

Potential Side Effects/Adverse Reactions

Side effects and reactions to the topical application of sodium guaiazulene sulfonate can vary from person to person. The points below outline potential issues yet they are unlikely for most users when the ingredient is included at standard cosmetic levels.

  • Mild transient stinging or burning on very compromised or freshly exfoliated skin
  • Redness or irritation if used in high concentrations or left on the skin for prolonged periods
  • Allergic contact dermatitis in individuals already sensitized to azulene compounds
  • Dryness or tightness if paired with other strong surfactants in a formula
  • Temporary eye irritation if the product accidentally gets into the eyes

If any of these reactions occur stop using the product and seek advice from a qualified healthcare professional.

Comedogenic Rating

Rating: 0. Sodium guaiazulene sulfonate is fully water-soluble and rinses away without leaving an oily film that could clog pores, which places it at the very bottom of the comedogenic scale. Its mild anionic surfactant action helps lift excess sebum rather than occluding it, making the ingredient a safe choice for those prone to acne or breakouts. Because it is typically used in low concentrations and in rinse-off products, the chance of pore congestion is considered negligible. No data suggest it exacerbates fungal acne either, so it is generally well tolerated across different acne concerns.

Summary

Sodium guaiazulene sulfonate serves mainly as a gentle cleanser that dissolves oil and grime, disperses evenly in water and lends a calming blue hue to formulas. It achieves these tasks through its sulfonate head, which behaves like a mild surfactant, and its hydrophilic sodium salt structure, which ensures quick rinsing and stability in water-based products.

Although not as commonplace as powerhouse surfactants like sodium laureth sulfate, it enjoys steady popularity in niche soothing cleansers, blue-tinted micellar waters and spa-style toners where a mild touch and visual appeal matter.

Overall safety data are strong with low irritation potential, no known hormonal concerns and virtually zero comedogenicity. Still, skin is personal, so it is wise to patch test any new product featuring this ingredient to confirm compatibility.

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