Sodium Hyaluronate Crosspolymer-5: What Is It, Cosmetic Uses, Benefits & Side Effects

Curious about this ingredient? In this article we're explaining exactly what it is and why it's used within cosmetic formulations.
Updated on: June 30, 2025
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We verify all information on this page using publicly available nomenclature standards from The Personal Care Products Council (PCPC), the European Commission's CosIng database and documentation provided directly by ingredient manufacturers. Our analysis is based on technical data from these sources to ensure accuracy and reliability.

What Is Sodium Hyaluronate Crosspolymer-5?

Sodium Hyaluronate Crosspolymer-5 is a modern spin on classic hyaluronic acid. Chemically it is the sodium salt of hyaluronic acid that has been crosslinked using triethylamine and chloromethyl-pyridinium iodide, creating a three-dimensional network. This crosslinked structure gives the molecule a “mesh” that holds water more tightly than ordinary hyaluronic acid, helping it stay on the skin surface longer.

The ingredient traces its roots to medical research in the 1990s that aimed to make hyaluronic acid more stable for eye and joint applications. Cosmetic chemists later adopted the same idea to boost hydration in leave-on products. Today manufacturers typically start with fermented, non-animal hyaluronic acid, react it with the crosslinking agents under controlled pH and temperature, then purify it into a fine powder that disperses easily in water-based formulas.

You will most often spot Sodium Hyaluronate Crosspolymer-5 in lightweight moisturizers, anti-aging serums, hydrating mists, overnight masks and under-eye gels. Brands choose it when they want the plumping effect of hyaluronic acid but with longer-lasting moisture and a smoother feel.

Sodium Hyaluronate Crosspolymer-5’s Cosmetic Benefits/Uses

This ingredient earns its place on an ingredient list by doing several helpful jobs at once:

  • Humectant: Draws water from the air and deeper skin layers to the surface, giving skin an instant fresh, dewy look while reducing the appearance of fine lines caused by dryness
  • Skin conditioning: Forms a breathable film that softens rough texture and boosts overall smoothness so skin feels supple to the touch
  • Emollient: Fills in tiny cracks between skin cells which helps prevent moisture loss and leaves the surface feeling silky rather than sticky

Who Can Use Sodium Hyaluronate Crosspolymer-5

Thanks to its gentle nature, Sodium Hyaluronate Crosspolymer-5 suits virtually all skin types, from dry and mature to oily and acne-prone. Its water-binding mesh delivers lightweight hydration without leaving a greasy film, so even combination or sensitive skin usually tolerates it well. People living in very low-humidity climates might want to top it with an occlusive cream to keep the captured moisture from evaporating, but the ingredient itself is not inherently problematic for any specific skin type.

The raw material is produced by bio-fermenting non-animal hyaluronic acid, so it fits vegan and vegetarian lifestyles.

No research indicates that topical Sodium Hyaluronate Crosspolymer-5 poses a risk during pregnancy or breastfeeding, yet this is not medical advice. Expectant or nursing women should consult a healthcare professional before adding any new skincare product, just to be safe.

The molecule does not make skin more sensitive to sunlight, so there is no added risk of photosensitivity. It also plays nicely with common actives such as vitamin C, niacinamide and retinoids, making it a flexible choice in most routines.

Potential Side Effects/Adverse Reactions

Reactions to topical Sodium Hyaluronate Crosspolymer-5 differ from person to person. The points below list potential side effects, yet most users will never experience them when the ingredient is used correctly in a well-formulated product.

  • Mild redness or itching
  • Temporary stinging on very compromised or freshly exfoliated skin
  • Rare allergic contact dermatitis due to sensitivity to the crosslinking agents or preservatives in the final formula
  • In extremely dry environments, possible feeling of tightness if no occlusive layer is applied over the product

If you notice any of these effects, discontinue use and consult a healthcare professional for guidance.

Comedogenic Rating

Rating: 0 / 5 (non-comedogenic)
Sodium Hyaluronate Crosspolymer-5 is a large, water-soluble molecule that sits on the skin surface rather than slipping into pores. It lacks oils or waxes that can block follicles so it does not foster the buildup that leads to whiteheads or blackheads. Its film-forming action is breathable and rinses away easily which further reduces any clogging risk.

Suitable for acne-prone or breakout-prone skin.

Formulas that pair this ingredient with heavy plant butters or thick silicones could still trigger congestion, but the crosspolymer itself remains non-comedogenic.

Summary

Sodium Hyaluronate Crosspolymer-5 acts as a humectant, skin conditioner and emollient. Its crosslinked “mesh” grabs water like a sponge, holds it near the surface then releases it slowly for lasting hydration. At the same time the lightweight film fills micro-gaps between skin cells so skin feels softer, smoother and more supple.

The ingredient is gaining popularity in modern serums, gels and mists because it offers the plumping power of classic hyaluronic acid with longer wear and a silky feel. You will see it more often as brands look for upgraded hydrators that work for every skin type.

Overall it is considered very safe and gentle, with a low chance of irritation or clogging. As with any new skincare product it is smart to patch test first to be sure your skin agrees with the full formula.

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