Sr-Cat Polypeptide-3: What Is It, Cosmetic Uses, Benefits & Side Effects

Curious about this ingredient? In this article we're explaining exactly what it is and why it's used within cosmetic formulations.
Updated on: June 30, 2025
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We verify all information on this page using publicly available nomenclature standards from The Personal Care Products Council (PCPC), the European Commission's CosIng database and documentation provided directly by ingredient manufacturers. Our analysis is based on technical data from these sources to ensure accuracy and reliability.

What Is Sr-Cat Polypeptide-3?

Sr-Cat Polypeptide-3 is a lab engineered form of fibroblast growth factor-2, a small protein that naturally supports cell renewal in skin and hair. Modern biotech techniques let scientists insert the genetic code for FGF-2 into harmless microorganisms such as yeast. These microbes are then grown in stainless steel fermenters, where they produce the peptide in large amounts. After fermentation the broth is filtered and purified, yielding a highly concentrated, skin-friendly ingredient.

Cosmetic chemists first explored growth factors in the early 2000s while searching for gentler ways to prompt youthful looking skin. Early successes with wound dressings inspired companies to adapt the technology for everyday beauty products, leading to the introduction of Sr-Cat Polypeptide-3 in premium serums. Today it shows up in anti-aging creams, sheet masks, overnight treatments, restorative scalp tonics and leave-in hair conditioners where it works alongside vitamins and plant extracts.

Sr-Cat Polypeptide-3’s Cosmetic Benefits/Uses

In formulas, Sr-Cat Polypeptide-3 offers three key actions that translate into visible beauty perks.

  • Antioxidant – helps neutralize free radicals generated by UV light and pollution which can dull skin tone and weaken hair strands, supporting a fresher look
  • Hair conditioning – forms a lightweight film on the cuticle that smooths frizz, boosts softness and improves combability without weighing hair down
  • Skin protecting – reinforces the skin barrier by encouraging natural repair processes so moisture stays in and irritants stay out, leading to a calmer complexion

Who Can Use Sr-Cat Polypeptide-3

Sr-Cat Polypeptide-3 is gentle enough for most skin types including dry, oily, combination and sensitive skin. Because it focuses on supporting the skin barrier rather than stripping or exfoliating, it rarely triggers irritation in delicate complexions.

The peptide is made in yeast through fermentation so no animal tissue is involved. This makes it suitable for vegans and vegetarians who prefer cruelty free and animal free ingredients.

Current data shows no specific risks for women who are pregnant or breastfeeding when the peptide is used in a cosmetic product. That said this is not medical advice and anyone who is expecting or nursing should check with a healthcare professional before adding new products just to be safe.

Sr-Cat Polypeptide-3 does not increase photosensitivity. Regular daytime sunscreen is still recommended to guard against ordinary sun damage.

Potential Side Effects/Adverse Reactions

Responses to topical Sr-Cat Polypeptide-3 can differ from one person to another. The points below list possible reactions but most users will not notice any problems when the ingredient has been formulated and stored correctly.

  • Temporary redness
  • Mild itching or tingling
  • Localized rash or hives indicating an allergy to the peptide or another formula component
  • Eye irritation if the product accidentally gets into the eyes

If any uncomfortable reaction develops discontinue use and seek medical advice if the symptoms do not settle quickly.

Comedogenic Rating

Rating: 0 out of 5. Sr-Cat Polypeptide-3 is a water-soluble protein fragment that does not leave a greasy residue or block pores. It lacks heavy oils or waxes that typically trigger breakouts, so it earns the lowest possible score on the comedogenic scale.

This makes the ingredient suitable for people who are prone to acne or congestion. If the overall product formula is light and non-occlusive the peptide itself should not contribute to clogged pores.

Because Sr-Cat Polypeptide-3 is usually added at low concentrations and is easily rinsed or absorbed, it is unlikely to build up on skin even with daily use.

Summary

Sr-Cat Polypeptide-3 delivers three main benefits: it acts as an antioxidant by neutralizing free radicals, conditions hair by forming a silky microfilm on strands and protects skin by supporting barrier repair so moisture stays in and irritants stay out. These effects stem from its origin as fibroblast growth factor-2, a protein that naturally encourages cell renewal.

While not yet a household name, the peptide has carved out a small but growing following in high-end serums, masks and scalp treatments that target early signs of aging and dryness. Brands appreciate its ability to boost performance without adding heaviness or fragrance.

Overall safety data are reassuring, with low rates of irritation and a non-comedogenic profile. Still, skin is personal so it is wise to patch test any new product containing Sr-Cat Polypeptide-3 to confirm it agrees with your complexion.

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