Sr-Cat Polypeptide-4: What Is It, Cosmetic Uses, Benefits & Side Effects

Curious about this ingredient? In this article we're explaining exactly what it is and why it's used within cosmetic formulations.
Updated on: June 30, 2025
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We verify all information on this page using publicly available nomenclature standards from The Personal Care Products Council (PCPC), the European Commission's CosIng database and documentation provided directly by ingredient manufacturers. Our analysis is based on technical data from these sources to ensure accuracy and reliability.

What Is Sr-Cat Polypeptide-4?

Sr-Cat Polypeptide-4 is a lab-crafted version of insulin-like growth factor 1, also known as somatomedin C. It belongs to the family of signal peptides used in skin and hair care. Modern biotechnology allows manufacturers to insert the genetic code for this peptide into friendly bacteria or yeast. After a controlled fermentation the peptide is purified, filtered, and blended into a stable cosmetic-grade powder or solution.

Peptides started turning up in beauty formulas in the early 2000s when brands looked for gentler, smarter ways to boost skin’s natural renewal. Sr-Cat Polypeptide-4 followed soon after as researchers realized its structure could support both skin and hair vitality without the irritation often linked with stronger actives.

You will most often find Sr-Cat Polypeptide-4 in lightweight facial serums, anti-aging creams, sheet masks, leave-on scalp tonics, strengthening conditioners, post-shave balms, and multipurpose moisturizers geared toward sensitive or maturing skin.

Sr-Cat Polypeptide-4’s Cosmetic Benefits/Uses

This multitasking peptide earns its place on an ingredient list by covering several bases at once:

  • Antioxidant – helps neutralize everyday environmental stressors such as pollution and sunlight which can otherwise speed up fine lines and dullness
  • Hair Conditioning – supports a smoother cuticle layer so strands feel softer, look shinier, and resist breakage during styling
  • Skin Protecting – forms a lightweight, breathable shield that reduces moisture loss and keeps the skin barrier comfortable throughout the day

Who Can Use Sr-Cat Polypeptide-4

Most skin types tolerate Sr-Cat Polypeptide-4 well. Its lightweight texture suits oily and combination skin while its barrier supporting action benefits dry or mature complexions. Sensitive skin generally accepts the peptide thanks to its gentle profile. People with a known allergy to fermented yeast or bacterial proteins should approach with caution since the peptide is produced through biotechnology.

The ingredient is considered vegan and vegetarian friendly because the peptide is synthesized by microbes in a controlled fermenter rather than being harvested from animal tissue. No animal derivatives are used during production.

Current research shows no special risks for pregnant or breastfeeding women when this peptide is applied topically in cosmetic doses. Absorption through intact skin is minimal. That said this text is not medical advice. Anyone who is pregnant or nursing should confirm product choices with a qualified healthcare provider.

Sr-Cat Polypeptide-4 does not make skin more sensitive to sunlight and can be used morning or night without raising the risk of sunburn. It layers easily with sunscreens antioxidants and hydrators and remains stable across the pH range found in most leave-on products.

Potential Side Effects/Adverse Reactions

Responses to topical Sr-Cat Polypeptide-4 vary from person to person. The points below list potential though uncommon side effects when the ingredient is used at cosmetic levels and properly manufactured. Most users will experience none of these issues.

  • Mild redness or warmth shortly after application
  • Temporary itching or tingling on very sensitive skin
  • Localized rash or hives in individuals allergic to peptide fragments or fermentation residues
  • Watery eyes if a spray or mist containing the peptide is used too close to the eye area
  • Scalp buildup or greasiness when over applied in leave-on hair tonics

If any uncomfortable reaction occurs stop using the product and consult a healthcare professional or dermatologist for guidance.

Comedogenic Rating

Rating: 0 / 5

Sr-Cat Polypeptide-4 is a water-soluble peptide with no oils, butters or fatty alcohols that might clog pores. It sits lightly on the skin surface, then absorbs or rinses away without leaving a waxy film. No data links it to increased sebum production or blocked follicles, which is why it earns a solid zero on the comedogenic scale.

Suitable for acne-prone or breakout-prone skin.

Because the peptide is often paired with lightweight gel or serum bases, the finished formulas also tend to be low in pore-clogging ingredients, giving an extra layer of reassurance to those managing blemishes.

Summary

Sr-Cat Polypeptide-4 is a lab-made copy of IGF-1 that acts as an antioxidant, hair conditioner and skin protector. It mops up daily environmental stress, smooths the hair cuticle for easier styling and helps hold moisture in the skin by supporting the surface barrier.

The peptide is still a niche player compared with headline ingredients like vitamin C or retinol, yet its gentle multitasking profile is gaining quiet traction in serums, masks and scalp tonics aimed at sensitive or mature users.

Safety data shows it is well tolerated with minimal risk when used at cosmetic levels. As with any new skincare or haircare step, do a quick patch test before full use to be on the safe side.

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