What Is Sr-Clostridium Botulinum Polypeptide-1 Decapeptide-40?
Sr-Clostridium Botulinum Polypeptide-1 Decapeptide-40 is a lab engineered peptide made by combining genetic sequences from two separate peptides then expressing the fused gene in a strain of E. coli. The result is a single chain of ten amino acids that is identical from batch to batch thanks to controlled fermentation. Because it is produced recombinantly, no animal or human tissue is involved, which helps keep the ingredient free of common contaminants.
The peptide was first explored by cosmetic chemists looking for gentler topical options that could mimic some of the smoothing effects people associate with injectables derived from botulinum toxins. By removing the toxic domains of the original bacterial protein and limiting the sequence to a short, non-toxic fragment, researchers created a safe version suitable for creams and serums.
Manufacturing starts with a synthesized DNA template inserted into E. coli. The bacteria grow in stainless-steel fermenters, churn out the peptide, then are broken open so the peptide can be purified, filtered and spray-dried into a fine powder. That powder is blended into water or glycerin to make a stable solution that labs can easily add to finished formulas.
You will typically find Sr-Clostridium Botulinum Polypeptide-1 Decapeptide-40 in leave-on anti-aging serums, firming eye creams, sheet masks, moisturizing lotions and targeted wrinkle-smoothing ampoules.
Sr-Clostridium Botulinum Polypeptide-1 Decapeptide-40’s Cosmetic Benefits/Uses
The main role of this peptide in topical products is skin conditioning. It helps soften the skin surface, improve its overall feel and support a smoother appearance by temporarily relaxing the look of expression lines.
Who Can Use Sr-Clostridium Botulinum Polypeptide-1 Decapeptide-40
This peptide is generally suitable for all skin types, including dry, normal, combination and oily. Because it is lightweight and non occlusive it will not add extra heaviness to oil-prone skin, yet its conditioning action still brings comfort to drier complexions. Sensitive skin usually tolerates it well since the molecule is small and used at low concentrations, though individuals with a known sensitivity to fermented or bioengineered ingredients should tread carefully.
The material is produced entirely through bacterial fermentation without any animal-derived inputs, so it is considered vegan and vegetarian friendly.
No published data link topical Sr-Clostridium Botulinum Polypeptide-1 Decapeptide-40 to harm during pregnancy or breastfeeding. That said, ingredient safety research is still limited. This is not medical advice and anyone who is pregnant or nursing should discuss new skincare products with a qualified health professional before use to stay on the safe side.
The peptide does not increase photosensitivity nor does it interfere with daily sunscreen use. It can be applied morning or night without making skin more prone to sunburn.
Potential Side Effects/Adverse Reactions
Responses to any skincare ingredient vary from person to person. The issues listed below are only potential effects and are unlikely for most users when the finished product has been properly formulated.
- Temporary redness or mild irritation
- Localized itching or tingling
- Rare allergic contact dermatitis presenting as a rash
- Stinging if applied to broken or compromised skin barriers
- Potential interaction with other highly active peptides leading to overstimulation in very sensitive skin
If any of these reactions occur discontinue use and consult a healthcare professional if symptoms persist or worsen.
Comedogenic Rating
Rating: 0/5. Sr-Clostridium Botulinum Polypeptide-1 Decapeptide-40 is a water-based peptide with no oil content, waxes or heavy film-forming agents that could clog pores. It stays dissolved in the water phase of a formula and rinses clean during daily cleansing, so it does not linger inside follicles to trap sebum or debris.
Because of this, it is considered suitable for skin that breaks out easily.
As with any ingredient, overall pore-friendliness also depends on the other components in the final product such as emollients, fragrances and preservatives.
Summary
Sr-Clostridium Botulinum Polypeptide-1 Decapeptide-40 is a lab-crafted decapeptide that conditions skin and helps soften the look of dynamic lines by mildly relaxing surface tension. Its tiny size lets it sit comfortably on the skin where it can smooth texture and leave a silky feel without heaviness.
The peptide is still a niche player, mostly seen in higher-end serums and targeted eye treatments rather than mass-market moisturizers, but interest is growing as brands look for gentle topical options that echo injectable results.
Current data show it to be low risk for irritation, non-comedogenic and free of animal derivatives. Even so, everyone’s skin is unique so it is smart to patch test any new product containing this peptide before applying it to the entire face.