What Is Sr-Clostridium Botulinum Polypeptide-1 Sh-Oligopeptide-1?
Sr-Clostridium Botulinum Polypeptide-1 Sh-Oligopeptide-1 is a lab created fusion peptide made by combining genetic material from a botulinum peptide with that of a well known cell signaling peptide called sh-Oligopeptide-1. Scientists insert the fused gene into harmless E. coli bacteria, let the bacteria ferment in controlled tanks then harvest and purify the 500-amino-acid chain they produce. The finished peptide may form small bridges called disulfide bonds and can carry sugar groups, both of which help it keep a stable shape on the skin.
The idea of blending botulinum inspired sequences with growth-factor style peptides is fairly recent, growing out of research that looked for gentle topical options that could soften the look of lines without injections. As peptide technology became easier and less costly, formulators started adding this ingredient to high-end skin care to give products a high tech edge.
You will mostly spot Sr-Clostridium Botulinum Polypeptide-1 Sh-Oligopeptide-1 in anti-aging serums, firming creams, sheet masks, overnight treatments and premium moisturizers that promise smoother brighter skin.
Sr-Clostridium Botulinum Polypeptide-1 Sh-Oligopeptide-1’s Cosmetic Benefits/Uses
This multitasking peptide helps a formula defend and support the skin in two main ways
- Antioxidant – helps neutralize free radicals created by UV light and pollution which can dull skin and speed up visible aging keeping the complexion looking fresher for longer
- Skin protecting – supports the skin barrier so it can hold on to moisture better and stay resilient against daily aggressors such as wind heat or harsh cleansers
Who Can Use Sr-Clostridium Botulinum Polypeptide-1 Sh-Oligopeptide-1
This peptide works for most skin types including dry, normal, combination and oily because it is lightweight and non occlusive. Sensitive skin usually tolerates it well since it lacks fragrance and harsh solvents, though anyone with a known peptide allergy should avoid it.
Because the ingredient is produced in a fermentation tank with E. coli and contains no animal derived materials it suits both vegans and vegetarians. Final suitability also depends on whether the finished product is certified cruelty free by the brand.
Data on use during pregnancy or while breastfeeding is limited. The molecule is large so it is unlikely to penetrate deeply yet out of caution pregnant or nursing individuals should discuss any product containing this peptide with a healthcare professional as this is not medical advice.
The ingredient does not make skin more sensitive to sunlight and can be used morning or night without increasing the risk of sunburn. It can be paired with most actives including vitamin C retinoids and niacinamide without destabilising them.
Potential Side Effects/Adverse Reactions
Responses to topical Sr-Clostridium Botulinum Polypeptide-1 Sh-Oligopeptide-1 differ from person to person. The points below outline potential side effects that may occur in rare cases. Assuming the formula has been manufactured correctly most users will not notice any problems.
- Temporary redness or flushing minor warmth can appear when the product is first applied especially on very reactive skin
- Mild itching or tingling short lived sensation that generally subsides within minutes
- Contact dermatitis persistent rash or swelling if the immune system views the peptide or another formula component as an irritant
- Allergic reaction hives or severe itching caused by a true allergy to the peptide protein chain
- Interaction with highly acidic products formulas below pH 3 may alter peptide stability leading to irritation for some users
If any of these effects develop stop using the product and consult a healthcare professional for personalized guidance.
Comedogenic Rating
Rating: 0/5 – Sr-Clostridium Botulinum Polypeptide-1 Sh-Oligopeptide-1 is a large water soluble peptide that does not form an oily film or block pores so it is considered non comedogenic. It sits on the skin surface, delivers its benefits then rinses away with normal cleansing.
This makes the ingredient suitable for people who are prone to acne or breakouts.
As with any cosmetic the final formula matters. Heavy creams rich in butters or waxes could still clog pores even if this peptide itself does not.
Summary
Sr-Clostridium Botulinum Polypeptide-1 Sh-Oligopeptide-1 acts as an antioxidant and skin protector. Its 500 amino acid chain helps mop up free radicals from sunlight and pollution while supporting the skin barrier so moisture stays in and irritants stay out. These actions can soften the look of fine lines and keep skin feeling resilient.
The peptide is still a niche player compared with classics like retinol or vitamin C but it is showing up more often in premium serums, sheet masks and overnight creams aimed at smoothing and firming.
Overall safety data looks good. The molecule is too large to enter the bloodstream and it is produced in a controlled lab setting free from animal sources. Side effects are rare and usually mild. As with any new skincare product it is smart to patch test first to check personal tolerance before applying to the whole face.