What Is Sr-Escherichia Coli Methionyl Cow Polypeptide-3 Ferment Lysate Extract?
Sr-Escherichia Coli Methionyl Cow Polypeptide-3 Ferment Lysate Extract is a skin care ingredient created from a carefully controlled fermentation process. Scientists start with a strain of the common bacterium E. coli and give it the genetic instructions to produce a small fusion peptide made of cow polypeptide-3 linked to the amino acid methionine. The bacteria are grown in a nutrient-rich broth until they have produced large amounts of this peptide. The cells are then broken apart, or lysed, and the resulting mixture is filtered and purified to collect the peptide-rich lysate. This extract is valued for the way it can bind water to the skin surface, helping formulas feel fresh and hydrating.
The idea of using bacterial ferment lysates in cosmetics is not new. Over the last few decades brands have explored yeast and bacterial ferments for their ability to add moisture and support a healthy skin barrier. Building on that work, formulators turned to E. coli because it is well understood in the lab and can produce peptides with high precision. By fusing cow polypeptide-3 with methionine, researchers created a peptide that stays stable in water-based products and offers reliable hydration benefits.
You will most often see Sr-Escherichia Coli Methionyl Cow Polypeptide-3 Ferment Lysate Extract in lightweight moisturizers, hydrating serums, sheet masks, soothing after-sun gels and anti-aging creams that aim to plump the look of fine lines. Because it mixes easily into water phases, it suits both gel and lotion textures and can be added late in the manufacturing process to protect its activity.
Sr-Escherichia Coli Methionyl Cow Polypeptide-3 Ferment Lysate Extract’s Cosmetic Benefits/Uses
This ingredient is valued for its ability to attract and hold water in the upper layers of skin.
- Humectant: Acts like a moisture magnet by drawing water from the environment and deeper skin layers to the surface. This helps keep skin feeling soft, smooth and supple while reducing the appearance of dryness lines. It also improves the spreadability of a formula so products glide on more evenly and leave a dewy finish.
Who Can Use Sr-Escherichia Coli Methionyl Cow Polypeptide-3 Ferment Lysate Extract
This humectant suits most skin types, including dry, normal, combination and oily because it delivers weightless hydration without leaving a greasy film. Sensitive skin generally tolerates it well since the peptide has a low potential for irritation, though individuals highly reactive to ferment ingredients should proceed with care. It is not known to clog pores, so acne-prone users can usually enjoy its benefits.
The fusion peptide is produced entirely inside a laboratory fermenter. No animal tissues are harvested, yet the genetic code for part of the peptide comes from a bovine protein. Strict vegans may prefer to avoid it for that reason while many vegetarians and cruelty-free shoppers consider it acceptable.
No data suggest specific risks for pregnant or breastfeeding women when the ingredient is applied to intact skin, but this is not medical advice. Expectant or nursing mothers should review any skincare product with their physician to be safe.
The extract does not make skin more sensitive to sunlight, so it does not require extra sun precautions beyond your usual SPF. It also plays nicely with common actives like niacinamide, hyaluronic acid and mild exfoliating acids.
Potential Side Effects/Adverse Reactions
Responses to topical Sr-Escherichia Coli Methionyl Cow Polypeptide-3 Ferment Lysate Extract vary from person to person. The points below outline potential side effects, though most users will not experience them when the ingredient is properly formulated and preserved.
- Redness or mild burning sensation in very sensitive skin
- Itching or small hives in individuals allergic to peptide ferment derivatives
- Contact dermatitis if formulated with harsh preservatives or fragrances that interact with the lysate
- Rare bacterial contamination during manufacturing leading to irritation or breakouts
If any discomfort or visible reaction occurs stop using the product and consult a healthcare professional.
Comedogenic Rating
Rating: 0/5 Sr-Escherichia Coli Methionyl Cow Polypeptide-3 Ferment Lysate Extract is a lightweight water-soluble humectant that does not form an oily film on the skin or stay trapped in pores. Because it lacks heavy oils, waxes or long-chain fatty acids it is extremely unlikely to block follicles or trigger comedones.
Suitable for acne-prone and breakout-prone skin.
Formulas that combine this lysate with richer emollients could change the overall pore-clogging potential so check the full ingredient list if congestion is a concern.
Summary
Sr-Escherichia Coli Methionyl Cow Polypeptide-3 Ferment Lysate Extract is mainly a humectant that binds water to the upper skin layers, giving a plumper smoother look while improving the feel of a formula. Its small peptide structure lets it mix easily into water phases where it attracts moisture and helps maintain a balanced barrier.
Still a niche biotech ingredient, it appears in select hydrating serums, gels and masks rather than mass-market moisturizers. Interest is growing as brands look for novel peptide ferments that hydrate without heaviness.
Current data show a low risk of irritation or comedogenicity when the extract is properly preserved. As with any new skincare product, patch testing is a smart step to confirm personal tolerance.