Sr-Hydrozoan Polypeptide-1: What Is It, Cosmetic Uses, Benefits & Side Effects

Curious about this ingredient? In this article we're explaining exactly what it is and why it's used within cosmetic formulations.
Updated on: June 30, 2025
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We verify all information on this page using publicly available nomenclature standards from The Personal Care Products Council (PCPC), the European Commission's CosIng database and documentation provided directly by ingredient manufacturers. Our analysis is based on technical data from these sources to ensure accuracy and reliability.

What Is Sr-Hydrozoan Polypeptide-1?

Sr-Hydrozoan Polypeptide-1 is a lab made fragment of collagen that originally comes from a small sea creature called Podocoryna carnea. Scientists copy the part of the animal’s DNA that tells it how to build fibrillar collagen, then place that DNA into friendly E. coli bacteria. The bacteria act like mini factories, fermenting sugars and pumping out the peptide. After fermentation the protein is filtered, refined and dried to a pure powder. Because the process is controlled from start to finish it is free of animal contaminants and has a consistent quality from batch to batch.

The idea of using marine inspired peptides in beauty care took off in the early 2000s when researchers noticed that certain sea organisms build strong flexible tissues. Brands began looking for gentle yet effective ways to mimic those benefits for skin and hair. As a result Sr-Hydrozoan Polypeptide-1 now appears in a range of products including anti-aging serums, sheet masks, daily moisturizers, leave-on hair conditioners, styling creams and even sunscreens that aim to boost protection.

Sr-Hydrozoan Polypeptide-1’s Cosmetic Benefits/Uses

This versatile ingredient brings several helpful actions to modern formulas:

  • Film forming – Creates a light breathable layer on skin or hair that locks in active ingredients and gives a smooth feel
  • Hair conditioning – Helps strands feel softer and look shinier by smoothing rough cuticles and reducing static
  • Humectant – Attracts water from the air and pulls it into the surface of skin or hair which supports lasting hydration
  • Skin conditioning – Leaves skin feeling supple and refreshed while reducing the look of fine lines caused by dryness
  • UV filter – Adds an extra touch of protection by absorbing some UV rays which can help formulas support daily defense alongside traditional sunscreens

Who Can Use Sr-Hydrozoan Polypeptide-1

Thanks to its lightweight water-binding nature Sr-Hydrozoan Polypeptide-1 suits most skin types including dry, normal, combination and sensitive skin. Oily and acne-prone users generally tolerate it well because it is non-greasy and has a very low likelihood of clogging pores. Only those who react easily to any protein or peptide should proceed with extra caution.

The peptide is produced entirely in a lab using fermenting bacteria rather than harvesting from marine animals so it is considered vegan and vegetarian friendly.

No data suggest special risks for women who are pregnant or breastfeeding when the ingredient is applied topically at cosmetic levels. This is not medical advice and anyone expecting or nursing should review their full routine with a qualified healthcare provider to be safe.

Sr-Hydrozoan Polypeptide-1 does not increase photosensitivity. In fact it can contribute a mild boost to UV defense when paired with regular sunscreens.

The peptide layers well with most common actives such as niacinamide, hyaluronic acid, SPF filters and silicones making it easy to slot into existing routines.

Potential Side Effects/Adverse Reactions

Individual responses to topical Sr-Hydrozoan Polypeptide-1 vary. The effects listed below are possible yet unlikely for the average user when the product is formulated correctly.

  • Redness or mild irritation in very sensitive or compromised skin
  • Transient stinging if applied to freshly exfoliated or broken skin
  • Allergic contact dermatitis in rare cases of specific peptide sensitivity
  • Eye irritation if the product accidentally migrates into the eyes

If any of these reactions occur stop using the product and seek advice from a medical professional.

Comedogenic Rating

Rating: 0/5 – Sr-Hydrozoan Polypeptide-1 is a small water-based protein fragment that dissolves fully in the watery phase of a formula and leaves no greasy residue on skin. Because it is not an oil, butter or wax it does not block pores on its own. This makes it a friendly pick for people who are prone to acne or breakouts.

Keep in mind that the finished product matters. If the peptide sits in a rich cream loaded with heavy oils the overall formula could still feel occlusive. Check the full ingredient list when pore clogging is a concern.

Summary

Sr-Hydrozoan Polypeptide-1 is a lab grown fragment of marine collagen that acts as a film former, humectant, skin and hair conditioner and even gives a mild UV boost. It grabs water, smooths the surface and leaves a light flexible layer that helps skin look fresh and hair look glossy.

Although not yet a household name it is turning up in more serums masks and leave-in hair products because brands like its gentle touch and vegan origin. Safety data show very low risk when used topically at cosmetic levels, with rare reports of irritation or allergy.

Overall it is considered safe and non pore clogging for most users. As with any new ingredient try a small patch first to be sure it plays well with your unique skin.

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