Sr-Jellyfish Polypeptide-1: What Is It, Cosmetic Uses, Benefits & Side Effects

Curious about this ingredient? In this article we're explaining exactly what it is and why it's used within cosmetic formulations.
Updated on: June 30, 2025
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We verify all information on this page using publicly available nomenclature standards from The Personal Care Products Council (PCPC), the European Commission's CosIng database and documentation provided directly by ingredient manufacturers. Our analysis is based on technical data from these sources to ensure accuracy and reliability.

What Is Sr-Jellyfish Polypeptide-1?

Sr-Jellyfish Polypeptide-1 is a lab refined fragment of the green fluorescent protein first found in the jellyfish Aequorea victoria. Scientists originally studied this protein for its glowing quality, yet they soon noticed that parts of the molecule could form a thin, flexible film on skin. Cosmetic chemists isolated the protective peptide chain, removed the fluorescent portion, and created a stable ingredient that keeps the skin surface from losing water and shields it from daily stress. Production usually starts with a safe, bioengineered culture of the gfp10 gene placed in yeast or plant cells that act as tiny factories. After fermentation the peptide is purified, filtered, and dried into a fine powder that dissolves easily in water based formulas. Today you will most often find Sr-Jellyfish Polypeptide-1 in soothing sheet masks, hydrating serums, anti-aging creams, light lotions, and post-sun treatments that aim to calm and protect the skin barrier.

Sr-Jellyfish Polypeptide-1’s Cosmetic Benefits/Uses

When added to your skin care routine Sr-Jellyfish Polypeptide-1 works mainly as a skin protecting agent. It forms a breathable film that locks in moisture, helps reduce redness from minor irritation, and guards the surface against environmental factors such as wind or dry indoor air. This gentle shield can make other active ingredients feel less harsh, allowing formulas to hydrate more effectively and leave skin looking smoother and more comfortable.

Who Can Use Sr-Jellyfish Polypeptide-1

Sr-Jellyfish Polypeptide-1 is gentle so it suits dry, normal, combination and sensitive skin types. Oily or acne-prone skin can also use it because the peptide is light and does not add extra oil. There are no known reasons any skin type must avoid it.

The peptide is made in lab grown yeast or plant cells, not harvested from live jellyfish, so the final material is free from animal parts and is considered suitable for vegans and vegetarians.

Current data shows no issues for women who are pregnant or breastfeeding when this ingredient is used on intact skin. Peptides are large molecules that stay on the surface and do not reach the bloodstream. That said this is not medical advice and anyone who is pregnant or nursing should have a doctor review all skincare products first just to be safe.

Sr-Jellyfish Polypeptide-1 does not cause photosensitivity, so it will not make skin more likely to burn in the sun. Standard daytime sun protection is still recommended when using any skincare routine.

Potential Side Effects/Adverse Reactions

Side effects and reactions to topical Sr-Jellyfish Polypeptide-1 can differ from person to person. The issues listed below are possible yet unlikely when the ingredient is used correctly in a well-formulated product.

  • Mild redness or stinging in very sensitive skin
  • Itching from an individual allergy to the peptide or a preservative in the product
  • Contact dermatitis if combined with other irritating ingredients in the same formula

If any discomfort or irritation occurs stop using the product and consult a healthcare professional if symptoms persist.

Comedogenic Rating

Rating: 0 (non-comedogenic)

Sr-Jellyfish Polypeptide-1 is a lightweight water-soluble peptide that sits on the surface in a microscopically thin film, so it does not clog pores or trap excess oil. It contains no fats, waxes or heavy silicones that might block follicles, and typical use levels are very low. This makes it suitable for skin that is prone to acne or breakouts.

Because the peptide rinses away easily and is often paired with calming humectants, it is unlikely to contribute to fungal acne flare-ups either.

Summary

Sr-Jellyfish Polypeptide-1 is a lab crafted fragment of the famous jellyfish green fluorescent protein that acts as a skin-protecting film former. By laying down a breathable shield it helps lock in moisture, lessens everyday irritation and lets other hydrators work more efficiently, leaving skin smoother and more comfortable.

While the peptide is gaining interest in soothing masks and barrier creams, it is still a niche player compared with staples like hyaluronic acid or niacinamide. Those who have tried it often appreciate its featherlight feel and ability to calm redness without adding oil.

Overall safety data are excellent, with very low risk of irritation or allergy for most users, but as with any new skincare ingredient it is wise to patch test a fresh product first to rule out individual sensitivities.

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