Sr-Rainbow Trout Oligopeptide-1 Sh-Polypeptide-11: What Is It, Cosmetic Uses, Benefits & Side Effects

Curious about this ingredient? In this article we're explaining exactly what it is and why it's used within cosmetic formulations.
Updated on: June 30, 2025
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We verify all information on this page using publicly available nomenclature standards from The Personal Care Products Council (PCPC), the European Commission's CosIng database and documentation provided directly by ingredient manufacturers. Our analysis is based on technical data from these sources to ensure accuracy and reliability.

What Is Sr-Rainbow Trout Oligopeptide-1 Sh-Polypeptide-11?

Sr-Rainbow Trout Oligopeptide-1 Sh-Polypeptide-11 is a lab made fusion peptide that links two naturally occurring protein fragments from rainbow trout into one chain of 154 amino acids. Scientists build the gene that codes for this chain, insert it into friendly E. coli bacteria then let the microbes grow in a fermentation tank. After harvest the peptide is purified, checked for quality and blended into cosmetic bases.

Because the chain can form disulfide bonds and pick up sugar groups, it folds into a stable shape that stays active on skin and hair. The ingredient first showed up in Asian skin care labs looking for fish based growth factors that were kinder to the planet than harvesting fish parts directly. Once fermentation techniques improved, brands started adding the peptide to age-defying creams and soothing masks. Today you will find it in lightweight serums, rich moisturizers, eye creams, sheet masks, leave-on hair conditioners and scalp tonics where a touch of protein protection is desired.

Sr-Rainbow Trout Oligopeptide-1 Sh-Polypeptide-11’s Cosmetic Benefits/Uses

This multi-tasking peptide supports both skin and hair care formulas in several ways:

  • Antioxidant: Helps neutralize everyday environmental stressors like pollution and UV light which can speed up visible aging. By mopping up free radicals it helps keep skin tone brighter and hair fibers stronger
  • Hair conditioning: Deposits a thin protein layer that smooths the cuticle, boosts shine and improves combing ease. Regular use can reduce breakage and make hair feel softer without heavy oils
  • Skin protecting: Forms a breathable film that locks in moisture, calms minor irritation and supports the skin barrier so complexion looks supple and resilient

Who Can Use Sr-Rainbow Trout Oligopeptide-1 Sh-Polypeptide-11

This peptide is gentle enough for most skin types including dry, normal, combination and oily. Its lightweight film forming action adds moisture without heaviness so even acne prone or sensitive complexions usually tolerate it well. People with a known fish protein allergy should be cautious since the sequence is based on trout, although the fermentative process removes actual fish material.

The ingredient is produced in bacteria rather than harvested from animals so it is considered vegan and vegetarian friendly. Some ethical vegans who avoid anything with an animal gene origin may still prefer to skip it.

No data suggest that topical use poses a risk during pregnancy or breastfeeding. As a general precaution this is not medical advice and anyone who is pregnant or nursing should ask a healthcare professional before adding new skincare.

Sr-Rainbow Trout Oligopeptide-1 Sh-Polypeptide-11 does not increase sensitivity to sunlight and it plays well with common actives like niacinamide and hyaluronic acid. It can be layered under sunscreen and makeup without pilling.

Potential Side Effects/Adverse Reactions

Responses to a topical peptide differ from person to person. The points below describe potential side effects yet most users will not experience them when the finished product is formulated and stored correctly.

  • Mild redness or stinging right after application
  • Temporary itching in very sensitive skin
  • Contact dermatitis in individuals allergic to fish related proteins
  • Rare clogged pores if a formula also contains heavy oils or waxes

If any persistent irritation, rash or swelling occurs stop use immediately and consult a dermatologist or healthcare provider.

Comedogenic Rating

Rating: 0–1. Sr-Rainbow Trout Oligopeptide-1 Sh-Polypeptide-11 is a large water-soluble peptide that does not contain oils, waxes or fatty alcohols that typically block pores. It sits on the surface as a light film then rinses or wears off without building up inside follicles, so the risk of triggering blackheads or pimples is very low.

Because of this near non-comedogenic profile it is generally considered suitable for people who are prone to acne or breakouts. Only when the peptide appears in a rich formula loaded with heavier emollients could pore clogging become a concern, and that would be due to the base ingredients rather than the peptide itself.

Summary

Sr-Rainbow Trout Oligopeptide-1 Sh-Polypeptide-11 works as an antioxidant, skin protector and hair conditioner. Its 154-amino-acid chain can scavenge free radicals, form a thin moisture-holding shield on skin and hair and smooth damaged cuticles for added shine.

The peptide is still a niche addition, popping up most often in specialty K-beauty serums, eye creams and scalp tonics, but its eco-friendly fermentation origin is helping it gain quiet traction with ingredient-savvy shoppers.

Topical use has a strong safety record, with only rare redness or itching in very sensitive users. As with any new cosmetic active it is smart to do a small patch test when first trying a product containing this peptide to rule out personal sensitivity.

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