Sr-Rainbow Trout Oligopeptide-1 Sh-Polypeptide-13: What Is It, Cosmetic Uses, Benefits & Side Effects

Curious about this ingredient? In this article we're explaining exactly what it is and why it's used within cosmetic formulations.
Updated on: June 30, 2025
Share:
Inside this article:

We verify all information on this page using publicly available nomenclature standards from The Personal Care Products Council (PCPC), the European Commission's CosIng database and documentation provided directly by ingredient manufacturers. Our analysis is based on technical data from these sources to ensure accuracy and reliability.

What Is Sr-Rainbow Trout Oligopeptide-1 Sh-Polypeptide-13?

Sr-Rainbow Trout Oligopeptide-1 Sh-Polypeptide-13 is a lab made fusion peptide inspired by proteins originally found in rainbow trout. Scientists link together two short protein fragments, then insert the combined gene into a friendly strain of E. coli. The bacteria act like tiny factories, turning sugar and nutrients into the 219 amino-acid peptide. After fermentation the peptide is purified, checked for quality, and prepared for use in skin and hair care.

The idea of borrowing helpful fish proteins for cosmetics started gaining traction in the early 2000s when researchers noticed their strong antioxidant power. By fusing the trout fragment with another well studied peptide, developers created a single chain that is stable, water soluble, and easy to blend into formulas. Because it is produced by fermentation no actual fish parts end up in the final material, making it suitable for products aimed at eco conscious shoppers.

Today you will most often find this ingredient in anti aging serums, hydrating sheet masks, high performance moisturizers, leave-in hair conditioners, and protective creams aimed at urban or outdoor lifestyles.

Sr-Rainbow Trout Oligopeptide-1 Sh-Polypeptide-13’s Cosmetic Benefits/Uses

This multi tasking peptide supports both skin and hair in several ways

  • Antioxidant: Helps neutralize free radicals that form after sun exposure or pollution so it can reduce the look of dull tired skin and help slow visible signs of aging
  • Hair conditioning: Forms a lightweight film along the hair shaft which smooths the cuticle, boosts softness, and adds subtle shine without weighing strands down
  • Skin protecting: Supports the skin barrier by binding water and reinforcing surface proteins, leading to better moisture retention and a calmer feel when exposed to wind or harsh cleansers

Who Can Use Sr-Rainbow Trout Oligopeptide-1 Sh-Polypeptide-13

This peptide is lightweight water soluble and non greasy so it suits most skin types including dry, normal, combination, oily and mature skin. Sensitive skin often tolerates it well because it has a neutral pH and no known harsh preservatives. Those with very reactive or fish related allergies should still read labels carefully though the final material contains no fish proteins.

Because the peptide is made by fermenting a lab built gene in bacteria and no animal tissue is used during production products containing it are generally considered suitable for vegetarians and vegans. Some strict vegans may still prefer to avoid it since the original genetic sequence was inspired by a fish protein.

Current safety data shows no specific risks for pregnant or breastfeeding people when the peptide is applied topically in cosmetic amounts. This is not medical advice and anyone who is pregnant or nursing should discuss any new skincare product with their doctor first to be safe.

The ingredient does not increase photosensitivity so it will not make skin more prone to sunburn. Daily sunscreen is still recommended for overall skin health. Sr-Rainbow Trout Oligopeptide-1 Sh-Polypeptide-13 also layers well with common actives like niacinamide or hyaluronic acid without causing pilling or instability.

Potential Side Effects/Adverse Reactions

Side effects from topical use of Sr-Rainbow Trout Oligopeptide-1 Sh-Polypeptide-13 vary from person to person. The points below outline potential reactions yet most users will not experience them when the ingredient is properly formulated and used as directed.

  • Mild skin irritation such as transient redness or warmth, usually fading within minutes
  • Itching or tingling in those with very sensitive skin
  • Allergic contact dermatitis in rare cases where the immune system reacts to the peptide or other formula components
  • Eye irritation if the product is accidentally rubbed into the eyes
  • Scalp buildup or greasiness when over applied in leave-in hair products leading to dull looking roots
  • Interaction with highly acidic actives like strong exfoliating acids which could destabilize the peptide and lower its effectiveness

If any persistent burning, swelling or rash develops stop using the product and consult a healthcare professional.

Comedogenic Rating

Rating: 0 (non-comedogenic)

Sr-Rainbow Trout Oligopeptide-1 Sh-Polypeptide-13 is a large water-soluble peptide that sits on the skin surface then rinses or absorbs without blocking pores. It contains no oils waxes or fatty acids that typically lead to congestion so it earns the lowest score on the clog-pore scale.

Because of this low rating the ingredient is generally suitable for people who are prone to acne or breakouts.

Keep in mind that the overall formula still matters. Heavy creams rich in butters or certain silicones could cancel out the peptide’s non-comedogenic nature even if the peptide itself is pore-friendly.

Summary

Sr-Rainbow Trout Oligopeptide-1 Sh-Polypeptide-13 works as an antioxidant a skin protector and a hair conditioner. Its long chain of 219 amino acids can grab onto free radicals cushion the skin barrier and form a light film on hair fibers for extra smoothness and shine. All three benefits come from the same basic property: the peptide’s ability to interact gently with proteins and water at the surface level creating a flexible shield that keeps moisture in and stressors out.

This is still a niche bio-engineered ingredient so you will mostly see it in higher end serums masks and leave-in conditioners rather than drugstore basics but its presence is growing as brands look for clean lab-made actives.

Current data points to a high safety profile with very low risk of irritation or pore clogging. As with any new product though it is wise to run a quick patch test before full use just to be safe.

Was this article helpful?
More from Glooshi:
ADVERTISEMENT
Get all our top headlines in beauty.
Delivered right to your inbox each week. Zero spam, all goodness, opt-out at anytime.
This site is protected by reCAPTCHA and the Google Privacy Policy and Terms of Service apply.
Get the latest beauty news, top product recommendations & brand-exclusive discount codes direct to your inbox.
Send good feedback:

All feedback is greatly appreciated, anonymous, and will be used to improve the quality of our articles.

This site is protected by reCAPTCHA and the Google Privacy Policy and Terms of Service apply.
Send bad feedback:

All feedback is greatly appreciated, anonymous, and will be used to improve the quality of our articles.

This site is protected by reCAPTCHA and the Google Privacy Policy and Terms of Service apply.
Search