Sr-Sea Raven Polypeptide-1: What Is It, Cosmetic Uses, Benefits & Side Effects

Curious about this ingredient? In this article we're explaining exactly what it is and why it's used within cosmetic formulations.
Updated on: June 30, 2025
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We verify all information on this page using publicly available nomenclature standards from The Personal Care Products Council (PCPC), the European Commission's CosIng database and documentation provided directly by ingredient manufacturers. Our analysis is based on technical data from these sources to ensure accuracy and reliability.

What Is Sr-Sea Raven Polypeptide-1?

Sr-Sea Raven Polypeptide-1 is a type II antifreeze protein originally discovered in the blood of the sea raven, a cold-water fish that thrives in near-freezing oceans. In nature this protein prevents ice crystals from forming inside the fish’s tissues, a property that caught the attention of skin care scientists looking for new ways to shield skin from everyday stress factors. Chemically it is a short chain of amino acids arranged in a repeating pattern that binds to emerging ice nuclei, stopping them from growing. For cosmetic use the peptide is produced through controlled fermentation: a harmless strain of bacteria is given the gene that codes for the sea raven protein, the bacteria then ferment in stainless steel tanks and the peptide is purified, filtered and dried into a fine powder.

Its journey into beauty formulas began in the early 2000s when researchers noticed that the same ice-blocking action could help keep water molecules evenly dispersed on the skin’s surface, limiting dehydration caused by cold air and indoor heating. Today you are likely to find Sr-Sea Raven Polypeptide-1 in hydrating serums, winter-care moisturizers, soothing masks, after-sun gels and anti-aging treatments that promise to fortify the skin barrier.

Sr-Sea Raven Polypeptide-1’s Cosmetic Benefits/Uses

In skin care formulas Sr-Sea Raven Polypeptide-1 serves one key role: skin protecting. By forming a breathable micro-film on the surface it helps limit moisture loss, cushions skin against temperature swings and reduces the impact of environmental irritants. The result can be skin that feels calmer, stays hydrated longer and appears less prone to roughness or flaking during harsh weather.

Who Can Use Sr-Sea Raven Polypeptide-1

This peptide is gentle enough for all skin types. Very dry or sensitive skin may notice the biggest boost because the micro-film helps lock in moisture, yet the ingredient is light enough that oily and combination skin usually tolerate it without feeling greasy. Current data shows it is non-comedogenic so it should not clog pores.

Although the protein was first found in a fish, the cosmetic grade is grown by bacteria in a lab. No animal tissue is collected during production, making it suitable for vegans and vegetarians who are comfortable with bio-fermented ingredients.

Available safety reviews have not flagged any concerns for women who are pregnant or breastfeeding. The molecule is large and stays on the surface of the skin rather than entering the bloodstream. That said this is not medical advice; anyone who is expecting or nursing should ask a doctor before adding new products to a routine.

Sr-Sea Raven Polypeptide-1 does not cause photosensitivity, so it will not make skin more prone to sunburn. Standard daily sunscreen use is still recommended because UV rays are the top cause of premature aging.

Potential Side Effects/Adverse Reactions

Side effects from topical Sr-Sea Raven Polypeptide-1 can vary from person to person. The points below list potential reactions only and most users will not experience them when the ingredient is used at the levels found in finished cosmetics.

  • Mild redness or warmth a transient flush can appear if the formula contains a high concentration or other active ingredients that boost circulation
  • Stinging on very compromised skin freshly exfoliated or wind-burned skin may feel a brief tingle when the peptide is applied
  • Contact allergy extremely rare rash or itching in individuals sensitive to a specific amino acid sequence within the peptide
  • Ingredient conflict formulas that pair the peptide with high levels of alcohol or fragrance could increase dryness or irritation in sensitive users

If any persistent discomfort, swelling or rash develops stop using the product and consult a healthcare professional.

Comedogenic Rating

Rating: 0 / 5. Sr-Sea Raven Polypeptide-1 is a water-soluble peptide that sits on the surface of the skin, forms a light micro-film and contains no heavy oils, waxes or fatty acids that could block pores. Its large molecular size keeps it from absorbing into follicles where breakouts start, so it is considered non-comedogenic.

Because of this rating it is generally suitable for people who are prone to acne or frequent breakouts.

The only caveat is the rest of the formula: if the product pairs the peptide with rich butters or certain silicones, overall pore-clogging potential could change, so always look at the full ingredient list.

Summary

Sr-Sea Raven Polypeptide-1 is a lab-grown version of the sea raven’s antifreeze protein that acts as a skin-protecting agent. By binding water and forming a thin breathable shield it helps reduce moisture loss, cushions skin from temperature swings and keeps the surface feeling smooth and calm.

While not yet a mainstream superstar, the peptide has been gaining traction in winter moisturizers, barrier creams and after-sun gels aimed at sensitive or dehydration-prone skin. Early adopters value its vegan fermentation origin and gentle profile.

Current research and real-world use show the ingredient to be safe for all skin types with virtually no comedogenic risk or systemic absorption. Still, skin is personal, so doing a small patch test when trying any new product that contains Sr-Sea Raven Polypeptide-1 is a smart way to rule out individual sensitivities.

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