T-Butylbenzamido Hydroxylbenzamide: What Is It, Cosmetic Uses, Benefits & Side Effects

Curious about this ingredient? In this article we're explaining exactly what it is and why it's used within cosmetic formulations.
Updated on: June 30, 2025
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We verify all information on this page using publicly available nomenclature standards from The Personal Care Products Council (PCPC), the European Commission's CosIng database and documentation provided directly by ingredient manufacturers. Our analysis is based on technical data from these sources to ensure accuracy and reliability.

What Is T-Butylbenzamido Hydroxylbenzamide?

T-Butylbenzamido Hydroxylbenzamide is a lab made molecule whose full chemical name is 4-(4-(1,1-dimethylethyl)benzamido)benzenecarbohydroxamic acid. Chemists created it by linking two aromatic rings through an amide bond then adding a hydroxamic acid group and a bulky tert-butyl side chain. The tert-butyl group helps the ingredient stay stable when exposed to air and light while the hydroxamic portion is responsible for catching free radicals.

This ingredient was first explored in the early 2000s as researchers looked for new antioxidants that resist heat and UV stress better than common vitamins. Because it is fully synthetic manufacturers can control purity and batch-to-batch consistency. Production starts with p-aminobenzoic acid that is reacted with tert-butylbenzoyl chloride to form the amide, followed by conversion of the acid group to a hydroxamic acid under mild conditions. The finished powder is white to off-white and dissolves easily in oils and certain alcohols used in cosmetics.

Today formulators add T-Butylbenzamido Hydroxylbenzamide to a wide range of products where long-lasting antioxidant protection is needed. You will most often see it in anti-aging serums, day creams, sunscreens, sheet masks and after-sun gels. It can also appear in color cosmetics like foundations and tinted moisturizers to help keep the pigments from degrading over time.

T-Butylbenzamido Hydroxylbenzamide’s Cosmetic Benefits/Uses

In skin care formulas this ingredient serves two closely related roles that translate into visible benefits for the user

  • Antioxidant: It neutralizes free radicals generated by UV rays and pollution which helps slow the look of premature aging such as fine lines dullness and uneven tone. Its stability means it keeps working long after application supporting product shelf life as well
  • Skin protecting: By reducing oxidative stress it supports the skin’s natural barrier, helping it stay resilient against everyday environmental aggressors. This makes it a useful supporting active in sunscreen and urban defense products where extra protection is desired

Who Can Use T-Butylbenzamido Hydroxylbenzamide

This antioxidant is considered gentle and works well for most skin types including oily, dry, combination and sensitive skin. Its oil-soluble nature lets it sit comfortably on the surface without clogging pores which makes it a friendly option for acne-prone complexions. There are no known reasons for people with eczema, rosacea or easily irritated skin to avoid it although individual tolerance can vary.

Because the molecule is fully synthetic and made without any animal-derived reagents it is suitable for vegans and vegetarians. Manufacturing does not rely on animal testing in many regions thanks to alternative safety data, but shoppers who prefer cruelty-free labels should still check the brand’s overall policy.

Current research shows no evidence that the ingredient penetrates deeply or affects hormone balance so it is generally viewed as safe for pregnant or breastfeeding women. This is not medical advice and anyone who is expecting or nursing should share the full product list with a healthcare provider before use just to be safe.

T-Butylbenzamido Hydroxylbenzamide does not make skin more sensitive to sunlight and can actually boost the effectiveness of sunscreens by scavenging UV-induced free radicals. There are no known interactions with common actives like retinol, vitamin C or hydroxy acids so it can be layered easily in most routines.

Potential Side Effects/Adverse Reactions

Reactions to topical T-Butylbenzamido Hydroxylbenzamide differ from person to person. The points below outline potential side effects that might occur even though they are uncommon once the ingredient is used correctly in a finished formula.

  • Mild redness or warmth a short-lived flush can appear on very sensitive skin
  • Itching rare histamine-type response especially if combined with strong exfoliants
  • Dry patches possible if the formula lacks sufficient emollients to balance the antioxidant powder
  • Contact dermatitis extremely rare allergy to the amide portion of the molecule

If irritation develops stop using the product and consult a qualified healthcare professional for guidance.

Comedogenic Rating

Rating: 1 out of 5

T-Butylbenzamido Hydroxylbenzamide is classed as a low-risk clogger because the molecule is fairly large and sits on the skin surface rather than sinking into pores. It is typically used at low concentrations and is often blended with light emollients which further cuts the chance of buildup. A rating of 1 reflects this minimal but not entirely zero likelihood of causing blocked pores.

People who are prone to acne or regular breakouts can usually use products containing this antioxidant without trouble.

Keep in mind that a finished formula’s full blend of waxes oils and thickeners has more impact on breakouts than this single antioxidant.

Summary

T-Butylbenzamido Hydroxylbenzamide is a lab-made antioxidant that also protects skin from everyday stress. It works by grabbing free radicals created by sunlight pollution and heat then staying stable long enough to keep doing its job throughout the day. Its tert-butyl side chain shields the molecule from breaking down while the hydroxamic acid group is the part that neutralizes the radicals.

You will not see this ingredient everywhere yet. It is mainly found in higher-end serums sunscreens and some urban defense creams because it costs more than common antioxidants like vitamin E. Still formulators who want long-lasting protection and a clean safety record often pick it.

Current data shows it is well tolerated by most skin types including sensitive or acne-prone skin and it carries a very low risk of irritation. As with any new product it is wise to run a quick patch test first just to be sure your skin agrees with the full formula.

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