Tetrabutyl Ethylidenebisphenol: What Is It, Cosmetic Uses, Benefits & Side Effects

Curious about this ingredient? In this article we're explaining exactly what it is and why it's used within cosmetic formulations.
Updated on: June 30, 2025
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We verify all information on this page using publicly available nomenclature standards from The Personal Care Products Council (PCPC), the European Commission's CosIng database and documentation provided directly by ingredient manufacturers. Our analysis is based on technical data from these sources to ensure accuracy and reliability.

What Is Tetrabutyl Ethylidenebisphenol?

Tetrabutyl Ethylidenebisphenol is a man-made antioxidant that belongs to the bisphenol family. Chemically it is described as phenol, 2,2′-ethylidenebis[4,6-bis(1,1-dimethylethyl)] which means it has two bulky tert-butyl groups attached to each phenol ring. These large groups help the molecule trap unstable oxygen molecules called free radicals.

The ingredient was first explored in the plastics industry where strong antioxidants are needed to stop materials from breaking down when exposed to heat or light. Formulators later noticed that the same stabilizing traits could keep cosmetic creams fresh so it made its way into beauty labs during the late 1990s.

Production starts with phenol and acetaldehyde that react in the presence of an acid catalyst to create the ethylidene bridge. Additional steps add the tert-butyl groups which boost its antioxidant strength. After purification the white to off-white powder is ready for use in personal care labs.

You will most often see Tetrabutyl Ethylidenebisphenol in products that need to stay stable for a long time such as anti-aging serums, rich face creams, high-oil sunscreens, leave-on hair conditioners and treatment masks. It sits quietly in the background making sure oils, vitamins and fragrances do not turn rancid before you finish the jar.

Tetrabutyl Ethylidenebisphenol’s Cosmetic Benefits/Uses

Its role in a formula is straightforward yet important. As an antioxidant it sacrifices itself to neutralize free radicals created by light air or heat. This action helps stop the breakdown of oils, pigments and delicate actives so the product keeps its color scent and texture for longer. Indirectly it can also support skin health because a fresh stable product is less likely to cause irritation that comes from spoiled ingredients.

Who Can Use Tetrabutyl Ethylidenebisphenol

This antioxidant is considered skin friendly for most people. It is oil soluble yet used at very low levels so it normally sits well on dry, normal and oily skin alike without leaving a heavy film. Because it does not act as an active treatment it rarely upsets sensitive skin unless that skin is already reactive to phenolic compounds.

The ingredient is made synthetically from petro-based raw materials with no animal inputs so it is suitable for vegans and vegetarians.

Current safety reviews have not flagged special warnings for pregnancy or breastfeeding when the ingredient appears in leave-on cosmetics at typical concentrations. Even so this is not medical advice and anyone who is pregnant or nursing should show the full product label to a qualified healthcare professional before use.

Tetrabutyl Ethylidenebisphenol does not absorb UV light in a way that would make skin more prone to sun damage so it is not considered photosensitizing.

No known ingredient conflicts have been reported which means it can sit alongside common actives like retinol vitamin C or exfoliating acids without reducing their effects.

Potential Side Effects/Adverse Reactions

Responses to any cosmetic ingredient vary from person to person. The points below outline potential side effects of topical Tetrabutyl Ethylidenebisphenol though most users will not experience them when the product is well formulated and used as directed.

  • Mild skin redness or itching
  • Stinging sensation on very sensitive or compromised skin
  • Contact dermatitis in individuals already allergic to phenolic compounds
  • Eye irritation if the product accidentally gets into the eyes
  • Theoretical hormone-related concerns due to its bisphenol core though current cosmetic levels are far below doses seen to cause issues in lab studies

If any uncomfortable reaction occurs stop using the product and consult a healthcare professional for guidance.

Comedogenic Rating

Rating: 1/5. Tetrabutyl Ethylidenebisphenol is an oil-soluble powder yet it is added to formulas at fractions of a percent and does not form an occlusive layer on skin. Its bulky structure also keeps it from sinking deeply into pores where clogging typically starts. Because of this low likelihood of pore blockage it is generally suitable for acne-prone or breakout-prone users.

The only caveat is that the ingredient is most often found in rich creams and high-oil sunscreens whose overall base may feel heavy if you already struggle with congestion. In those cases the product’s full formula, not the antioxidant itself, is the factor to watch.

Summary

Tetrabutyl Ethylidenebisphenol is a lab-made antioxidant whose main job is to keep oils, pigments and delicate actives from degrading when exposed to heat, air or light. It performs this role by donating electrons to neutralize free radicals before those radicals can attack the rest of the formula.

Outside specialist labs it is hardly a household name because formulators have many antioxidant options and this one is reserved for products that need long-term stability under tough conditions. Still, when it does appear it works quietly and effectively.

Current data shows it is safe at the tiny levels used in cosmetics, with minimal irritation or sensitization reported. As with any new product, patch testing on a small area for a couple of days is a smart precaution to confirm personal compatibility.

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