What Is Tetracarboxymethyl Dihydroxybenzoyl Dipeptide-12?
Tetracarboxymethyl Dihydroxybenzoyl Dipeptide-12 is a lab made small peptide that has been linked to a plant based acid called dihydroxybenzoic acid. Chemists add four carboxymethyl groups to improve its water solubility, letting it blend smoothly into creams and gels. First studied for its ability to help keep skin tone even, it moved from research papers to skin care labs in the early 2010s when brands were looking for gentler options to support brighter, healthier looking skin. The ingredient is produced through a controlled reaction that joins the peptide portion with the modified plant acid, followed by careful purification to remove any leftovers from the process. You will most often spot it in brightening serums, daily moisturizers, sheet masks and age supporting treatments that promise a more even appearance.
Tetracarboxymethyl Dihydroxybenzoyl Dipeptide-12’s Cosmetic Benefits/Uses
This ingredient is prized for one key role in cosmetic formulas.
As a skin conditioning agent, it helps the skin feel soft and comfortable while supporting a more even look. Regular use can leave the complexion looking smoother and more radiant which is why formulators add it to products aimed at dull or uneven skin tone.
Who Can Use Tetracarboxymethyl Dihydroxybenzoyl Dipeptide-12
This peptide is generally well tolerated by all major skin types including dry, normal, oily and combination since it is water soluble and lightweight. Its gentle nature means even sensitive skin often gets along with it although anyone with a history of allergies to peptides or benzoic derivatives should proceed carefully. The ingredient is made entirely in a lab without animal-derived components so it suits both vegetarians and vegans. Current safety data shows no specific risks for women who are pregnant or breastfeeding when the ingredient is used topically in cosmetic amounts, yet this is not medical advice and those individuals should review any product containing it with a healthcare professional. Tetracarboxymethyl Dihydroxybenzoyl Dipeptide-12 does not make skin more prone to sunburn so it is not considered photosensitising. It can be paired with daily sunscreen and other routine products without special timing rules.
Potential Side Effects/Adverse Reactions
Responses to topical Tetracarboxymethyl Dihydroxybenzoyl Dipeptide-12 differ from person to person. The points below outline potential but unlikely side effects assuming the product has been formulated and stored correctly.
- Transient redness or warmth shortly after application
- Mild itching or tingling in very sensitive skin
- Allergic contact dermatitis presenting as rash or swelling
- Stinging when applied over freshly exfoliated or compromised skin
If you experience any of the above reactions stop using the product and consult a healthcare professional.
Comedogenic Rating
Rating: 0 / 5
Tetracarboxymethyl Dihydroxybenzoyl Dipeptide-12 is fully water soluble, light in texture and used at very low levels, so it does not leave heavy residues that could block pores. It also lacks oily carriers or waxes that often raise the risk of clogging. For these reasons it earns a solid non-comedogenic score.
Because it sits at 0 this peptide is generally considered suitable for people who are prone to acne or frequent breakouts.
No special storage or layering issues are known to change its non-comedogenic nature, but an overall formula with thick oils or butters could still feel heavy so check the full ingredient list.
Summary
Tetracarboxymethyl Dihydroxybenzoyl Dipeptide-12 is a lab crafted peptide that conditions skin and supports a more even, radiant look. It does this by helping the surface stay hydrated and calm which lets light reflect more smoothly so dull areas appear brighter.
You will not find it on every store shelf yet interest is growing as brands hunt for gentle brighteners that can be used daily without harsh side effects. Expect to see it most often in mid to high tier serums and masks rather than basic lotions.
Current research and cosmetic use show it is very safe for topical application with only rare reports of minor irritation. As with any new ingredient a quick patch test on a small area is the easiest way to be sure your skin agrees with it.