What Is Tetrapeptide-46?
Tetrapeptide-46 is a lab-made chain of four amino acids—alanine, leucine and phenylalanine—designed to match a small section of Antimicrobial Peptide 143 originally discovered in scorpion venom. Scientists identified that short stretch as especially friendly to skin, then recreated it synthetically so no animals are involved. The result is a tiny yet stable molecule that can be blended into water-based or emulsified formulas without breaking down.
The peptide emerged in cosmetic research during the early 2010s when brands began looking at animal-derived peptides for their skin-soothing traits. Because harvesting from scorpions is neither practical nor ethical, chemists used solid-phase peptide synthesis to string the four amino acids together in the exact order found in nature. This controlled process produces high purity powder that is then dissolved, filtered and added to finished products.
You will most often spot Tetrapeptide-46 in lightweight anti-aging serums, daily moisturizers, hydrating sheet masks and leave-on treatments aimed at calming sensitive or stressed skin. It pairs well with humectants such as glycerin and hyaluronic acid and is usually listed low on the ingredient deck because only a small amount is needed for effect.
Tetrapeptide-46’s Cosmetic Benefits/Uses
This peptide is prized for its skin conditioning ability, meaning it helps maintain a smooth supple feel while supporting the skin’s natural barrier. By attracting and holding moisture around surface cells it can leave the complexion looking plumper and less fatigued, which is why formulators reach for it in products that promise comfort and a fresher appearance.
Who Can Use Tetrapeptide-46
Tetrapeptide-46 is gentle enough for all skin types including dry, normal, combination oily and sensitive. Its lightweight texture means it will not weigh down oily complexions yet the conditioning action is comforting for dry or reactive skin. No specific skin type has been flagged as unsuitable because the peptide itself is non comedogenic and non occlusive.
The ingredient is produced entirely through synthetic chemistry with no animal or insect harvesting so it is suitable for vegans and vegetarians.
There are no known concerns for pregnant or breastfeeding women when Tetrapeptide-46 is used topically at the low levels found in cosmetics. This is not medical advice and anyone who is pregnant or nursing should show the full ingredient list of any product to their doctor before use just to be safe.
Tetrapeptide-46 does not make skin more sensitive to sunlight and it is stable in formulas that include sunscreen filters or other daytime actives. It is water soluble and does not interfere with makeup wear so it can be layered morning and night without special precautions.
Potential Side Effects/Adverse Reactions
Side effects from topical Tetrapeptide-46 can vary from person to person. The points below outline potential reactions but most users experience none of these when the ingredient is formulated and used correctly.
- Temporary redness
- Mild stinging or itching on application
- Localized irritation if applied over broken skin
- Rare allergic contact dermatitis in individuals sensitive to peptides
If any negative reaction occurs stop using the product and seek advice from a healthcare professional.
Comedogenic Rating
Rating: 0 / 5
Tetrapeptide-46 is a small water-soluble molecule that does not leave an oily film on skin and contains no fatty acids or waxy carriers that could block pores. Because it stays suspended in the water phase of a formula and is typically used at concentrations well under 1 percent, the likelihood of it trapping sebum or dead cells is extremely low. For these reasons it earns a solid 0 on the comedogenic scale.
This makes Tetrapeptide-46 suitable for acne-prone or breakout-prone skin.
Only the other ingredients in the finished product, such as heavy oils or butters, would change the overall pore-clogging potential, so check the full ingredient list if congestion is a concern.
Summary
Tetrapeptide-46 is a lab-crafted four-amino-acid peptide that conditions skin by helping surface cells hold on to moisture and maintain a resilient barrier. Thanks to its tiny size and water solubility it absorbs quickly, supports softness and leaves skin looking calm and refreshed.
Although not yet a household name like hyaluronic acid or niacinamide, the peptide is quietly gaining traction in specialty serums and masks where gentle barrier support is a selling point. Its cruelty-free synthetic origin appeals to vegan and eco-conscious shoppers.
Current data show Tetrapeptide-46 to be very safe for topical use with low risk of irritation or allergy. As with any new skincare ingredient, doing a small patch test before full application is a smart step for peace of mind.