Tetrapeptide-58: What Is It, Cosmetic Uses, Benefits & Side Effects

Curious about this ingredient? In this article we're explaining exactly what it is and why it's used within cosmetic formulations.
Updated on: June 30, 2025
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We verify all information on this page using publicly available nomenclature standards from The Personal Care Products Council (PCPC), the European Commission's CosIng database and documentation provided directly by ingredient manufacturers. Our analysis is based on technical data from these sources to ensure accuracy and reliability.

What Is Tetrapeptide-58?

Tetrapeptide-58 is a lab-made chain of four amino acids: cysteine, glycine, histidine and lysine. Scientists designed this short peptide to mimic some of the skin’s own building blocks, making it friendly and familiar to the skin’s surface. First explored in the early 2000s during the wave of peptide research aimed at smoother, firmer skin, it soon found a place in premium skin care lines. Creation starts with solid-phase peptide synthesis, a step-by-step method that links each amino acid in a controlled setting, followed by purification to remove any leftover materials. Because it is produced in a lab, no animal or plant sourcing is needed, which helps with consistency and reduces the risk of impurities. Today you will spot Tetrapeptide-58 in anti-aging serums, firming creams, eye treatments, sheet masks and rich moisturizers where its main job is to condition and support the skin’s feel and appearance.

Tetrapeptide-58’s Cosmetic Benefits/Uses

Tetrapeptide-58 is valued for one clear role in skin care

Skin conditioning: By helping the skin hold on to water and supporting a smoother surface, this peptide can leave the complexion feeling soft, supple and refreshed. It is often paired with hydrators like glycerin or hyaluronic acid, giving formulas an extra boost of comfort and a healthy-looking glow.

Who Can Use Tetrapeptide-58

Tetrapeptide-58 is generally well tolerated by all skin types, including dry, oily, combination and sensitive skin. Its gentle nature and focus on skin conditioning mean it rarely causes the tight or greasy feel that bothers some users. Extremely reactive or allergy-prone skin may still want to proceed with extra caution in case any peptide triggers a personal sensitivity.

Because the peptide is made entirely in a lab without animal-derived materials, it is considered suitable for both vegans and vegetarians.

No specific warnings exist for pregnant or breastfeeding women; however this is not medical advice and anyone who is expecting or nursing should check with a health professional before introducing a new product.

Tetrapeptide-58 does not make skin more prone to sunburn, so it is not regarded as photosensitizing. Standard daytime sun protection is still recommended for overall skin health.

Potential Side Effects/Adverse Reactions

Responses to topical Tetrapeptide-58 vary from person to person. The effects listed below are potential outcomes and are not expected to occur for most users when the ingredient is properly formulated and applied.

  • Mild redness or warmth that subsides within minutes
  • Transient tingling or stinging often linked to very sensitive skin
  • Rare allergic reaction presenting as persistent itching or small hives
  • Contact dermatitis if combined with other irritants in the same formula

If any of these reactions develop and do not calm quickly stop use and seek guidance from a healthcare provider or dermatologist.

Comedogenic Rating

Rating: 0 (non-comedogenic)

Tetrapeptide-58 is a small, water-soluble molecule that rinses away easily and does not leave an oily film on the skin. Because it lacks heavy waxes or fatty acids it has virtually no potential to block pores, earning it a true zero on the comedogenic scale. This makes it a suitable choice for people who are prone to acne or breakouts.

Keep in mind the overall formula still matters. If the peptide is blended into a thick balm rich in butters or occlusive oils, the finished product could still clog pores even though Tetrapeptide-58 itself will not.

Summary

Tetrapeptide-58 is a lab-crafted chain of four amino acids that conditions the skin by boosting water retention and supporting a smoother, softer surface. It partners well with classic hydrators like glycerin or hyaluronic acid, giving everyday moisturizers and serums an extra touch of comfort.

While peptides in general have become buzzworthy, Tetrapeptide-58 remains a niche but growing player most often found in mid to high-end anti-aging lines rather than mass-market lotions.

Safety data and user feedback point to a very low risk of irritation or pore clogging. Even so, everyone’s skin is unique so patch testing any new product that features Tetrapeptide-58 is a smart step before full application.

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